Supplementary appendix
This appendix formed part of the original submission and has been peer reviewed.
We post it as supplied by the authors.
Supplement to: Efficace F, Gaidano G, Breccia M, et al. Prognostic value of self-reported
fatigue on overall survival in patients with myelodysplastic syndromes: a multicentre,
prospective, observational, cohort study. Lancet Oncol 2015; published online Sept 22.
http://dx.doi.org/10.1016/S1470-2045(15)00206-5.
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APPENDIX ONLINE
Supplementary Table 1. Distribution of hemoglobin levels by patients’ self-reported baseline fatigue.
Self-reported levels of fatigue (EORTC QLQ-C30) Hemoglobin (g/dl) – Mean (SD)
0 9.79 (1.68) 11 10.31 (2.24) 22 10.05 (1.69) 33 9.27 (1.70) 44 9.18 (2.58) 55 8.99 (1.47) 66 9.04 (2.01) 77 9.24 (1.43) 88 8.87 (2.10) 100 8.31 (1.12)
Abbreviations: EORTC QLQ-C30, European Organization for Research and
Treatment of Cancer, Quality of Life Questionnaire-Core 30,SD, standard
deviation.
Legend : the table shows the distribution of mean hemoglobin levels according to the observed scores of patients’ self-reported fatigue scale of EORTC QLQ-C30 questionnaire. Fatigue scores of the EORTC QLQ-C30 range between 0 and 100, with higher scores indicating higher level of fatigue.
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APPENDIX ONLINE
General list of participating centers and Investigators involved:
Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont. Novara, Italy (Gianluca Gaidano, Monia Lunghi, Clara De Ambrogi)
Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy (Giuliana Alimena, Massimo Breccia, Maria Pia Loglisci)
Department of Hematology, University of Rome “Cattolica S. Cuore”. Rome, Italy (Maria Teresa Voso, Marianna Criscuolo)
Department of Medical Sciences, University of Cagliari. Cagliari, Italy (Giorgio La Nasa, Giovanni Caocci) Department of Internal Medicine V (Hematology and Oncology), Innsbruck Medical University. Innsbruck, Austria (Reinhard Stauder, Britta Halter)
Ematologia e Centro Trapianti. Ospedale Oncologico di Riferimento Regionale “Armando Businco”. Cagliari, Italy (Emanuele Angelucci, Anna Angela Di Tucci)
Department of Haematology, AZ St Jan Brugge-Oostende, Belgium (Dominik Selleslag, Tina Ducheyne) Department of Hematology and Stem Cell Transplantation Unit, IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy (Nicola Cascavilla, Grazia Sanpaolo)
Department of Medicine I, University hospital Dresden “Carl Gustav Carus”. Dresden, Germany (Uwe Platzbecker, Susann Pinkert, Susann Knack)
Department of Medicine, Department of Haematology, General University Hospital, Charles University, Prague, Czech Republic (Anna Jonasova)
Department of Internal Medicine, CHU Toulouse, Institut Universitaire du Cancer de Toulouse - Oncopole, 1 avenue I. Joliot-Curie, 31059 Toulouse Cedex 9, France (Odile Beyne-Rauzy, Nicolas Ferrieres)
Hematology, Department of Biomedicine and Prevention, Tor Vergata University. Rome, Italy (Sergio Amadori, Francesco Buccisano)
Department of Emergency and Organ Transplantation, Hematology Section, University of Bari. Bari, Italy (Giorgina Specchia, Alessandra Ricco)
UO Ematologia, AOU “Policlinico-V.Emanuele”. Catania, Italy (Giuseppe Palumbo, Elena Schinocca, Marco Ragusa)
St James’s Institute of Oncology, Bexley Wing. Leeds, UK (David Bowen, Ayna Beden)
Leukemia Department. The University of Texas MD Anderson Cancer Center. Texas, Houston, USA (Khanh Nguyen, Guillermo Garcia-Manero, Christina Meyers)
Department of Haematology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine. Shenyang, China (Huiyong Zhang)
School of Humanities and Management, Guangdong Medical College. Dongguan, China (Chonghua Wan, Yang Zheng)
3 Department of Haematology, S. Giovanni-Addolorata Hospital. Rome, Italy (Luciana Annino, Susanna Fenu)
Department of Internal Medicine I, University of Freiburg Medical Centre. Freiburg, Germany (Michael Lübbert, Johannes Waldschmidt)
Department of Oncology-Hematology, Hospital Center “Pugliese-Ciaccio”. Catanzaro, Italy (Luciano Levato, Stefano Molica, Maria Lentini)
Department of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation. Pavia, Italy (Carlo Balduini, Rosangela Invernizzi)
Complex Operative Hematology and Transplantation Unit, Lecce Local Health Service, Lecce, Italy (Nicola Di Renzo, Claudia Quintavalle)
Department of Public Health, College of Public Health, National Taiwan University, Roosevelt Road. Taipei, Taiwan, Republic of China (Weichu Chie)
Department of Haematology, Bradford Institute of Health Research. Bradford, UK (Sam Ackroyd, Victoria Drew)
Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute. Milan, Italy (Fabio Ciceri)
Oncology Department, CHC–Clinique Saint-Joseph. Liège, Belgium (Christian Focan)
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York. New York, USA (Stephen Nimer, Virginia Klimek, Emily Dolezal)
Department of Haematology, AZ Middelheim. Antwerp, Belgium (Robrecht De Bock, Jan Christiaens) Department of Haematology, Hospital de Jolimont. La Louviere, Belgium (Christophe Ravoet, Petre Helene) Istituto Oncologico Romagnolo per la Cura dei Tumori. Meldola, Italy (Maria Benedetta Giannini, Francesca Fabbri)
Haematology Unit, Sapienza University, Polo Pontino. Latina, Italy (Sergio Mecarocci)
Department of Haematology, University Campus Bio-medico, Roma, Italy (Giuseppe Avvisati, Carolina Nobile)
Division of Hematology, Niguarda Ca' Granda Hospital. Milano, Italy (Enrica Morra)
Division of Hematology, Università di Torino, Ospedale San Giovanni Battista. Torino, Italy (Giorgia Matta) Department of Onco-hematology, S. Maria della Misericordia Hospital. Rovigo, Italy (Rossella Paolini)
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List of participating centers and Principal Investigators by patients included:
PARTICIPATING CENTRE PRINCIPAL
INVESTIGATOR
RECRUITED PATIENTS PER CENTRE
Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont. Novara, Italy
Gianluca Gaidano 40
Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy
Giuliana Alimena 29
Department of Hematology, University of Rome “Cattolica S.
Cuore”. Rome, Italy Maria Teresa Voso 26
Department of Medical Sciences, University of Cagliari. Cagliari, Italy
Giorgio La Nasa 24
Department of Internal Medicine V (Hematology and Oncology), Innsbruck Medical University.
Innsbruck, Austria
Reinhard Stauder 16
Ematologia e Centro Trapianti. Ospedale Oncologico di Riferimento Regionale “Armando Businco”.
Cagliari, Italy
Emanuele Angelucci 15
Department of Haematology, AZ St Jan Brugge-Oostende, Belgium
Dominik Selleslag 13
Department of Hematology and Stem Cell Transplantation Unit, IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy
Nicola Cascavilla 11
Department of Medicine I, University hospital Dresden “Carl
Gustav Carus”. Dresden, Germany Uwe Platzbecker 10
Department of Medicine, Department of Haematology, General University Hospital, Charles University, Prague,
Czech Republic
Anna Jonasova 8
Department of Internal Medicine, CHU Toulouse, Institut Universitaire du Cancer de Toulouse - Oncopole, 1 avenue I. Joliot-Curie, 31059 Toulouse Cedex 9, France
Odile Beyne-Rauzy 7
Hematology, Department of Biomedicine and Prevention, Tor Vergata University. Rome, Italy
Sergio Amadori 7
Department of Emergency and Organ Transplantation, Hematology Section, University of Bari. Bari, Italy
Giorgina Specchia 7
UO Ematologia, AOU “Policlinico-V.Emanuele”. Catania, Italy Giuseppe Palumbo 6
5 Leukemia Department. The University of Texas MD Anderson
Cancer Center. Texas, Houston, USA
Khanh Nguyen 6
Department of Haematology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China
Huiyong Zhang 5
School of Humanities and Management, Guangdong Medical College. Dongguan, China
Chonghua Wan 5
Hematology Unit, “S. Eugenio Hospital” , Rome, Italy Pasquale Niscola 5
Department of Haematology, S. Giovanni-Addolorata Hospital. Rome, Italy
Luciana Annino 4
Department of Internal Medicine I, University of Freiburg Medical Centre. Freiburg, Germany
Michael Lübbert 4
Department of Oncology-Hematology, Hospital Center
“Pugliese-Ciaccio”. Catanzaro, Italy Luciano Levato 3
Department of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation. Pavia, Italy
Carlo Balduini 3
Complex Operative Hematology and Transplantation Unit, Lecce Local Health Service, Lecce, Italy
Nicola Di Renzo 2
Department of Public Health, College of Public Health, National Taiwan University, Roosevelt Road. Taipei, Taiwan, Republic of China
Weichu Chie 2
Department of Haematology, Bradford Institute of Health Research. Bradford, UK
Sam Ackroyd 2
Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute. Milan, Italy
Fabio Ciceri 2
Oncology Department, CHC–Clinique Saint-Joseph. Liège, Belgium
Christian Focan 2
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York. New York, USA
Stephen Nimer 2
Department of Haematology, AZMiddelheim. Antwerp, Belgium Robrecht De Bock 1
Department of Haematology, Hospital de Jolimont. La Louviere, Belgium
Christophe Ravoet 1
Istituto Oncologico Romagnolo per la Cura dei Tumori. Meldola, Italy
Maria Benedetta Giannini 1
Haematology Unit, Sapienza University, Polo Pontino. Latina, Italy
Sergio Mecarocci 1
Department of Haematology, University Campus Bio-medico, Roma, Italy
6 Division of Hematology, Niguarda Ca' Granda Hospital. Milano,
Italy
Enrica Morra 1
Division of Hematology, Università di Torino, Ospedale San Giovanni Battista. Torino, Italy
Giorgia Matta 1
Department of Onco-hematology, S. Maria della Misericordia Hospital. Rovigo, Italy.
