Cord Blood Banking: worldwide overview

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Cord Blood Banking: worldwide overview Joan Garc

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ü

To collect, store and supply CB units with

the highest quality and safety

ü

To improve the probability of finding

suitable HP donors

ü

To promote the clinical use of CB.

ü

To promote research on biology and clinical

application of CB

“

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The New York CBB is the first integrated program for cord blood banking and transplant: THE NATIONAL CORD THE NATIONAL CORD BLOOD PROGRAM. BLOOD PROGRAM. It has produced a number of crucial papers on the biology, processing and transplant of placental cells.

New York CBB: the pioneer

Inventory including more

than

40,000 units

• More than 2700 transplants performed • Associated to, NMDP, BMDW and NETCORD

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Individual cord blood banks cannot

accomplish their mission alone

Networks at national and international level:

one step ahead

• Purpose:

ü

Share inventory and requests

ü

Maintain international standards

ü

Augment and simplify communications

with transplant centres

ü

Further collaborations among banks

ü

Promote and advocate for cord blood

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Auscord is one of the first CBBs integrated program.

The CBBs of the Australian program are situated in the Sydney Sydney Children’s Hospital; the Royal Children’s Hospital, Melbourne Melbourne

and in the Mater Misericordiae Hospital in Brisbane Brisbane

Auscord

Inventory including more than 18,000 units – More than 378 transplants performed – Their communication systems acts through the Australian Bone Marrow Donors Registry. – Associated to BMDW and NETCORD

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Belgium CBB program

• It operates through the Belgium Cord Blood Registry and includes three CBBs: Brussels, Gant and Liege Brussels, Gant and Liege. . Leuvencord is an independent program with an inventory of 8000 units and 8000 units and more more than than 104 transplants 104 Associated to NETCORD Inventory including more than 6500 units – More than 200 transplants performed – Associated to NETCORD and FACT/NETCORD accredited

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FRANCE CORD

Is a single CBB program with a central coordination in Paris and other three Paris

operational locations: Besan Besanç çonon , Bordeaux , Bordeaux

and

and Annemasse (storage centreAnnemasse )

The whole French unrelated donors activity has been integrated in the recently created “Agence de la Biomedicine”. France Cord program has adopted the FACT/Netcord standards and, Besançon CBB is accredited. Overal inventory includes more than 6500 units – More than 700 transplants performed – Associated to NETCORD and BMDW

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Germany

CBBs programs: Dueseldorf Dueseldorf (Pioneer and COfounder of Netcord, developing and supporting the concept of Virtual Office) and Manheim,

Manheim, Gauting Gauting, , (Germany CORD).

Overal inventory includes more than 22900 units – More than 600 transplants performed – Associated to NETCORD. BMDW. Germany Cord – Duesseldorf: “José Carreras Cord Blood Bank Program” is one of the first FACT/NETCORD Accredited CBB..

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The Italian network

• First embryo on 1996 under the leadership of the Milano Milano Cord Blood bank Cord Blood bank

•Pioneer of the concept of cord blood inventories networking under a single quality assurance system (ISO 9000) The current Italian Network includes the 16 Italian active pubblic CBBs in a single network managed by IBMDR: Treviso, Padova, Milano, Torino, Pavia, Bologna, Genova,Firenze, Pisa, Lazio (Roma La Sapienza e Roma Tor Vergata), Roma Università Cattolica, Pescara, Napoli, Reggio Calabria, Verona) The current inventory includes more than 22.000 22.000 CBUs CBUs

• More than 650 units transplanted 650 units transplanted

• The Milano CBB has been one of the

NETCORD founders and one of the first to obtain the FACT/NETCORD accreditation.

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Israel Programs

• Tel Hassomer (Sheba) and Hadassa

Blood Bank

Blood Bank. One of the earliest programs..

• The current inventory includes 1385 and 1385 and 3312 stored

3312 stored CBUsCBUs , , respectively. • 31 units transplanted 31 units transplanted

• Collaboration with NETCORD, BMDW, NMDP

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• The USA National Marrow Donor Program has developed a network of 23 USA 23 USA and non USA and non USA CBBs CBBs : : • San Diego CA, Denver CO, Durham CN, Orange CA, Altamonte Springs FL, Glenview IL, Detroit MI, Gainesville FL, Houston TX, Camden NJ, Seattle WA, TelHashomer (Israel), St. Louis MO, Arcadia CA, LinKou (Taiwan), San Antonio TX, Orlando FL and Allendale NJ, Singapore, Sheba CBB (Israel), Taiwan CBB...

The NMDP

Cord Blood Program

• Current inventory: more than 87,000 units more than 87,000 units

• >2200 CBU >2200 CBU have been delivered for transplant. • Accreditation: AABB and FACT/NETCORD

• Operation through NMDP search system (in addition to 8M MUD)

• Associated to 171 USA and non USA transplant 171 USA and non USA transplant centers centers. • NMDP / NETCORD agreement NMDP / NETCORD agreement • Arcadia, Durham and Houston have already obtained the FACT/NETCORD accreditation. • Appointment for management of the Bill Young National CB program

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UK Programs

• NHS London Cord Blood Bank London Cord Blood Bank. One of the earliest programs, cofounder of Netcord.. The Antony Nolan Registry has launched a CBB program on 2008 Inventory including more than 9500 units – More than 220 transplants performed – Associated to NETCORD and FACT/NETCORD accredited

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The Spanish Network:

• Six regional CBBs and 11 donation programs: Barcelona (Catalonia, Barcelona

Balears, Aragon, Navarra,

Extremadura), Madrid, Malaga Madrid, Malaga

(Andalucia, Castilla La Mancha),

Santiago, Tenerife, Valencia.

Santiago, Tenerife, Valencia. • PESCU recently aproved.

It includes more than 30,000 stored CBU 30,000 stored CBU

more than 650 transplanted. 650 transplanted

Barcelona CBB has been one of the NETCORD founders. Málaga and Santiago CBB are NETCORD members. They operate in collaboration with the Spanish BMD registry: REDMO 0 5000 10000 15000 20000 25000 30000 35000 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

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Single site National Programs

• Eurocord Netherlands (Leiden) • 3505 stored units 3505 • 63 CBT 63 • Finland (Helsinki) • • 2856 stored units 2856 • 17 CBT 17 • Switzerland Cord • 1925 stored units 1925 • Hellenic CBB (Athens) • 560 560 stored units • 5 5 CBT • Czechia Cord (Prague) • • 2899 2899 stored units • 22 22 CBT • Mexico (CordMx) • 1029 stored units 1029 • 72 CBT 72 • SwedCord • 250 stored units250

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The Asian network:

Founded in November 2000 in Bangkok It includes the major CBB in Asia: Beijing, Tianjin, Seoul,Taipei, Ho Chi Minh, Bangkok and Tokyo. • Organization based on NETCORD statutes and standards. • Operated through an electronic search system. • Rapidly increasing inventory.

• Updated data from Taipei 13700 units 13700 units stored

stored and JCBBN: 29000 units stored and 29000 units stored more than 4384 transplants 4384 transplants generated.

• The Tokyo CBB is the more active one with 5710 units stored 740 transplants

5710 units stored 740 transplants performed.

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BMDW

• Pioneer organization on the procurement of unrelated donors for hemopoietic transplants founded on 1988, central offices in Leiden. • Voluntary collaborative effort with the goal to provide centralised information on the HLA and other relevant data of unrelated stem cell donors and cord blood units • Internal search algorithm based on the HLA typing of patients lists potential donors and their location. • Participants: 58 stem cell donor registries from 43 countries, and 38 cord blood banks from 21 countries. • The current number of donors and cord blood units : over 12,000,000 and 400,000, respectively

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• EUROCORD is an international registry on behalf of the

European Blood and Marrow Transplant group (EBMT),

including European and non European centres.

•

EUROCORD collaborates with CBBs by validation of

data and sending statistical analysis of the cord blood

transplants performed with their respective units to every

associated CBBs

• EUROCORD registrybased analysis has developed

crucial reports supporting the concept of establishing

cryopreserved cord blood banks for clinical use.

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A bit of history

…

The International NetCord Foundation

§ 1995: Genesis in Milano, Duesseldorf, Barcelona, Paris, London, New York, Tokio, Leiden, Denver…. § 1998: Founding of organization § 2000: Legally established as a foundation, chartered in Leiden, The Netherlands § 2001: Virtual Office opened in Duesseldorf § 2004: Executive Office opened in Chicago § 2006: Reorganized with new Bylaws and strategic plan § 2006: Concluded a first search agreement with NMDP § 2007: Second generation of officers and directors

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MISSION

•

To globally unite supply and demand for umbilical cord

blood.

•

To promote the highest quality cord blood products

through worldwide standards and an accreditation

process for cord blood banks.

•

To encourage and facilitate expanded uses of cord

blood transplants by promoting laboratory and clinical

research, as well as treatment outcome evaluation.

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NETCORD Officers

President Joan Garcia (Barcelona) VicePresident Elizabeth Shpall (Houston) Secretary Eliane Gluckman (Paris) Treasurer Yves Beguin (Liege) Immediate PastPresident Peter Wernet (Düsseldorf) Directors Riitta Kekomäki (Helskinki) Paolo Rebulla (Milano) Pablo Rubinstein (New York) Joan Kurtzberg (Durham) Cristina Navarrete (London) Markus Vowels (Sidney) Honorary Directors José Carreras Girolamo Sirchia Marcela Contreras International Councillors Ciril Rozman (Barcelona) Jon van Rood (Leiden) Managing Director Alan Leahigh (Chicago) Virtual Office Director Holger Gressmann (Düsseldorf)

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NETCORD

Achievements

•

NetCord/FACT Standards

•

Accreditation program

•

Search and procurement program:

The Virtual Office

•

Contribution to key scientific papers

•

Participation of >30 cord blood banks

•

More than 300 transplant centers

•

Strategic plan

•

Collaboration with the NMDP

Virtual office

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NetCordFACT Standards

Goals

•

To promote quality practices:

•

maternal and donor selection, screening, and

testing

•

cord blood collection, process, testing, banking,

selection, release, and transport.

•

To consistently assure provision of quality

CB units

•

To permit research and development

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FACT/NetCord Accredited Cord Blood Banks

Source

Source: : www.netcord. www.netcord.org org & & wwwwww . .factwebsite factwebsite.. orgorg Total CBB Applicants 57

(Applicants in US, UK, Europe, Asia)

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ONGOING AND FUTURE ACTIONS

•

Educational programs

•

Research programs

•

Marketing and promotional communications

•

Enhance communications with transplant centers

•

Strength relationships with other organizations

•

Collaboration with NMDP to create a global registry

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Issues

to

be

adressed

in

the

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CB Inventory must continue growing

• Histocompatibility implications

• Currently stored units:

»~ 400,000

»~ 100 CBBs

• Units on accredited CBBs (15):

»~ 200,000

(<50 % , > 1X10

9

NC)

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Continue promoting quality on

CBBs

Profile of Transplanted units: implications

14 5 16 6,7 17 6,9 0 2 4 6 8 10 12 14 16 18 19982001 20022004 20052006 NC x 10e8 CD34 x 10e6 Barcelona CBB data: Cellular content of stored and transplanted units 12,15 16 0 5 1 0 1 5 2 0 2 5 Stored Transplanted Barcelona CBB data: Evolution of cellular and progenitors content of transplanted units Storage of < 30% of collected units Storage of < 30% of collected units Larger collection programs Larger collection programs

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Summary

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Acknowledgments:

• AsiaCord • Auscord • Cordbloodbank of Bayerische Stammzellbank gGmbH • Eurocod • Eurocord Netherland. Leiden • Hadassa MDA/ Israel CBB • Hellenic CBB. Athens. • Jose Carreras CBB Düsseldorf • Milano Cord Blood Bank • National Cord Blood Program. NY. • Nationella biobanken för navelsträngsblod. Swedcord • Netcord Foundation • NHS London Cord Blood Bank • National Marrow Donor Registry • Programa SCU. Andalucia • Programa Nacional de Sangre placentaria CordMx • REDMO • Sheba CBB • Tokio CBB

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