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1. Glycolysis occurs in
A. Cytoplasm B. Mitochondrion
C. Both in cytoplasm and mitochondria D. Only in presence of O2
2. The oxidation of glucose or glycogen to pyruvate and lactate by EMF pathway is called as
A. Glycolysis B. Glycogeneis C. Glycogenlysis
D. The hexose monophosphate shunt
3. All these reactions take place inside the mitochondria except
A. EMF pathway B. Kreby cycle C. Urea cycle D. Electron transfer
4. The enzyme involved in the first committed step of glycolysis is
A. Phosphofructokinase B. Glucose – 6 – phosphatase C. Hexokinase
D. Enolase
5. All of the following are present in pyruvate dehydrogenase complex except
A. NAD B. FAD C. TPP D. GDP
6. Which of them is multienzyme complex.
A. Pyruvate dehydrogenase
B. Alpha ketoglutarate dehydrogenase C. Succinate dehydrogenase
D. Enolase
7. Pyruvate dehydrogenase complex contains all except
A. Biotin B. NAD C. FAD D. Co-A
8. Gluconeogenesis mainly occurs in which of the following organs.
A. Liver and kidney B. Kidney and heart
C. Muscle and liver D. None of the above
9. Which of the following enzyme is not involved in gluconeogenesis?
A. Pyruvate carboxylase B. Phosphoenol pyruvate C. Carboxy kinase D. Hexokinase
10. Which of the following compound is not a substrate for gluconeogenesis pathway?
A. Glycerol B. Lactate C. Oxaloacetate D. Glycogen
11. The key enzymes of gluconeogenesis is
A. Pyruvate carboxylase B. Fructose 1,6 diphosphatase C. Glucose 6 phosphatase
D. Phosphonol pyruvate carboxykinase
12. Enzymes concerned with the citric acid cycle are found in the
A. Nucleus B. Ribosomes C. Mitochondria
D. Non particular cytoplasm
13. Kreb’s cycle occurs in _______ condition
A. Aerobic B. Anaerobic C. Microaerophilic
D. Aerobic and anaerobic.
14. Krebs cycle operates in
A. Aerobic conditions only B. Anaerobic conditions only
C. Aerobic and anaerobic conditions D. Microaerophilic conditions
15. How may ATP molecules are produced in the citric acid cycle itself?
A. One B. Two C. Twelve D. Fifteen
16. Which of the following statement is not true for HMP shunt pathway?
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B. NADPH is producedC. Pentoses are produced D. Does not produce ATP
17. Sites where HMP shunts can occur include
A. liver B. WBC
C. Lactating mammary glands D. Testes
E. All
18. Step in HMP pathway requiring TPP
A. G6 PD
B. 6 phosphogluconat dehydrogenase C. Transketolase
D. Transaldotase
19. In the mitochondria, urea cycle is integrated to
A. Electron transport chain B. Oxidative phosphorylation C. Oxidation of fatty acids D. TCA cycle
20. Urea has two nitrogen atoms; the first comes from ammonia; which compound is the source of second nitrogen atom
A. Aspartate B. Glutamate C. Citrulline D. Ornithine
21. Name the bye – product of the urea cycle
A. Aspartate B. Ammonia C. Ornithine D. Fumarate
22. Which of the following substance is a key substance in the manufature of both purines and pyrimidine?
A. Carbomyl phosphate B. Adenosyl metheonine
C. Phosphoriboxyl pyrophosphate D. None of the above
23. Carbamoyl phosphate is required for the synthesis of
A. Pyrimidines B. Purines C. ATP D. RNA
24. The committed step in the synthesis of pyrimidine nucelotide is
A. Formation of UMP
B. Formation of dihydro-orotic acid
C. Formation of N-carbomoyl asparatic acid D. Formation of arotic decarboxylase.
25. Fatty acid oxidation occurs in
A. Cytoplasm B. Microsomes C. Mitochondria D. All of the Above
26. Which of the following fatty acids are not synthesised in human body?
A. Oleic, linoleic and linolenic acid B. Arachidonic, linolenic and linoleic acid C. Palmitic, oleic and arachidonic D. Linoleic, arachidonic and stearic acid
27. A fatty acid that is not synthesized in man is
A. Linoleic acid B. Oleic acid C. Palmitic acid D. Stearic acid
28. The lipoprotein particles that have the highest percentage concentration of cholestrol is
A. Chylomicron
B. VLDL (very low density lipoprotein) C. LDL (low density lipoprotein) D. HDL(high density lipoprotein)
29. The most important role of cholesterol is
A. It is a component of cell membrane
B. It is a precursor of polyunsaturated fatty acids
C. A stores up energy D. None of the above
30. β - oxidation of old - chain fatty acids produce
A. Succinyl CoA B. Propionyl CoA C. Acetyl CoA D. Malonly CoA
31. The total blood concentration of ketone bodies in well fed individual is
A. 1 mg % B. 5 mg % C. 12 mg % D. 20 mg %
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32. The humarn plasma lipoprotein containing the highest percentage of tricacylglycerol by weight is
A. VLDL
B. Chylomicrons C. HDL
D. LDL
33. High content of cholesterol is present in
A. Coconut oil B. Egg yolk
C. Hydrogenated fat D. Ghee (unsaturated)
34. Fatty acids help in synthesis of all except
A. Glucose B. Cholesterol C. Ketone bodies D. Fat
35. Insulin caused lipogenesis by all except
A. Increasing acetyl CoA corboxylase activity B. Increasing the transport of glucose in to the
cells
C. Inhibits pyruvate dehydrogenase D. Decreases intracellular cAMP level
36. Lipid is required in the average diet because it
A. Has a high caloric value B. Provides essential fatty acids C. Acids in absorption of carbohydrates D. Is necessary for storage of carbohydrates
37. The main pathway for “De-Novo” synthesis of fatty acids occurs in
A. Mitochondria B. Nucleus C. Cytosol
D. None of the above
38. The reducing equivalent for fatty acid synthesis is derived from
A. Glycolysis B. Kreb’s cycle C. Urea cycle
D. Pentose phosphate pathway
39. The following is not a phospholipid
A. Sphingomyelin B. Lecithin C. Cerebroside
D. Cephalin
40. Which of the following is lost from white matter in multiple sclerosis?
A. Phospholipids B. Sphingolipids C. Both of the above D. None of the above
41. Which of the following fatty acid is not an essential fatty acid?
A. Linoleic acid B. Linolenic acid C. Arachidonic acid D. Palmitic acid
42. The essential fatty acid is
A. Linoleic acid B. Palnoific acid C. Stearic acid D. Oleaic acid
43. The measure of degree of unsaturation of a fat is
A. Saponification number B. Iodine number
C. Acid number D. None of the above
44. The fat which is esterifies with alcohol of high molecular weight are known as
A. Simple fats B. Oils C. Waxes D. Triglycerides
45. The lipoproteins rich in cholesterol are
A. HDL B. VLDL C. LDL
D. Chylomicron
46. Fats absorbed with the help of bile salts are
A. Free fatty acids B. Glycerol
C. Higher fatty acids, diglycerides and monoglycerides
D. All of the above
47. Site of β-oxidation of fatty acid is
A. Cytoplasm B. Mitochondria
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C. Both cytoplasm and mitochondriaD. Lysosomes
48. α – oxidation is important in catabolism of
A. All fatty acids
B. Branched chain and odd chain fatty acids C. Fatty acids in brain
D. B + C
49. Increased cholesterol level in blood is found
A. Diabetes mellitus B. Nephrotic syndrome C. Obstructive jaundice D. All of the above
50. The ratio of HDL – cholesterol which is considered average risk for coronary artery disease is
A. 51 for G and 4.51 for E B. 9.51 for G and 71 for E C. 21 for G and 1.5 1E D. None of the above