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The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells

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Figure

Fig. 1 Characterization of TIC cultures derived from human MPMs.conditions: a Morphology of MM1, MM3, and MM4 TICs maintained in stem cell-permissive upper panels, sphere-forming cells derived from xenografted tumors in mice and grown as nonadherent cluste
Fig. 2 Sorafenib impairs cell viability and proliferation in MPM primary cultures enriched in TICs.on cell survival assessed by MTT assays, in MM1, MM3, and MM4 cells treated with increasing amounts of sorafenib for 24, 48, and 72 h
Fig. 3 Sorafenib causes MPM TIC cell cycle arrest in the G0/G1 phase.bof three independent experiments
Fig. 4 Sorafenib induces apoptosis and downregulates Mcl-1 expression in MPM TICs. a Amount of cell death (early and late apoptosis) in TIC cul-tures after IC50 and 2 × IC50 sorafenib exposure for 48 and 72 h
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