MODIFIED NATURAL CARRIER IN SOLID DISPERSION FOR ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE DRUGS

Vol 12, Issue 2, 2019 Online 2455 3891 Print 0974 2441 SOLID DISPERSION A NOVEL APPROACH FOR BIOAVAILABILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS IN SOLID ORAL DOSAGE

Differential scanning calorimetry (DSC) studies of pure drug and carriers and nanohybrids of individual drug with individual carriers performed to assess what changes

Various methods to increase the solubility of drugs are available such as solid dispersion, self emulsifying drug delivery, Liquisolid techniques etc, in which drug in

Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. Over the years a variety

The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, extruding method, spray drying

Hence, two areas of pharmaceutic research that focus on improving the oral bioavailability of active agents include; enhancing solubility and dissolution

Various techniques are used for the improvement of the aqueous solubility, dissolution rate, and bioavailability of poorly water soluble drugs include micronization,

Cryogenic spray processes are novel techniques that can be used to increase the solubility and therefore to enhance the dissolution rate and bioavailability of poorly soluble drugs