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Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses

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Figure

FIGURE 1. Nrated by PAGE.C18 columns eluted under a gradient of propanol and water.of PrP-Linked glycans did not affect the conversion of PrPC to PrPSc.A, immunoblot showing PrPC (lane 1) and deglycosylated PrPC (lane 2) sepa- B, the amounts of deglycosyla
FIGURE 3. Desialylated PrPPrPvalues are means(control medium, 10 ng of PrPwith control medium (C is not converted to PrPSc
FIGURE 5. Sialic acid on the GPI affects the composition of membranefrom four precipitates, each measured in triplicate (significantly higher than in PrPimmunoprecipitates.PrPrafts.Prnp(0/0)neuronswerepulsedwith25ngofPrPCor25ngofdesialylatedPrPC and homoge
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