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Hemophilia A gene therapy via intraosseous delivery of factor VIII-lentiviral vectors

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Figure

Fig. 1 GFP expression in BM cells following IO infusion of M-GFP-LV.of 10 a Schematic of IO infusion of vectors into the mice with an infusion speed μl/min, which was precisely controlled by a programmable microfluidics syringe pump
Fig. 2 Comparison of hFVIII levels in plasma and/or platelets after a single IO infusion of E-F8-LVs and G-F8-LVs
Fig. 3 hFVIII expression in platelets of G-F8-LV treated inhibitor HemA mice corrected their hemophilia A phenotype

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