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<em>MC1R</em> variants as melanoma risk factors independent of at-risk phenotypic characteristics: a pooled analysis from the M-SKIP project

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Academic year: 2020

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Table 1 Description of the studies included in the analysis
Figure 1 Forest plot for NDE, NIE, and TE of any MC1R variant on melanoma risk.Notes: CDE estimates the direct effect of MC1R on melanoma when the mediator is controlled at level 0 (absent) or 1 (present) uniformly in the population, NDE essentially averages CDE over the population, NIE estimates the indirect effect of MC1R mediated by RH phenotype, and TE is the overall melanoma risk estimate for MC1R carriers and in each study is the product of NDE and NIE.Abbreviations: CDE, control direct effect; NDE, natural direct effect; NIE, natural indirect effect; PY, publication year; RH, red hair; SOR, summary OR; TE, total effect.
Figure 2 Forest plot for control direct effect of any MC1R variant on melanoma risk according to RH phenotype.*Notes: *Defined as presence of red hair, freckles, or skin type I/II
Table 2 ORs with 95% CIs for melanoma risk according to a base clinical model and the same model with inclusion of MC1R variants

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