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Induction of differentiation of undifferentiated cells into pancreatic beta cells in vertebrates

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Figure

Fig. 1. Structural differences between human and mouse pancreatic islets. In the human islet, b-cells and a-cells are intermingled (left)
Fig. 2. Strategies for obtaining pancreatic b-cells from undifferentiated cells. Pan-creatic buds autonomously differentiate into pancreatic tissue when isolated and grafted under the kidney capsule in immunodeficient mice (dotted line)
Fig. 3. Schematic representation of in vitro organ induction with Xenopus animal caps
Fig. 4. Methods for obtaining pancreatic b-cells from human ES/iPS cells. The steps of each protocol are aligned based on the use of cytokines, low molecular weight compounds, and supplements for the culture medium
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