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Endothelin receptor B is required for the expansion of melanocyte precursors and malignant melanoma

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Figure

Fig. 1. Schematic representation of the endothelins and theirinteractions with endothelin receptors
Fig. 2. Characteristic differences in spotting patterns between awhite and black hair and (right) a mouse with an EDNRB deficiency withmouse carrying a mutation in the c-kit receptor (left), with intermingledsharp margins between white and black regions.
Fig. 3. c-kit can promote survival and differentiation by activating the transcriptional activity of MITFwhich will induce the expression of BCL2 and Tyrosinase.regulated is by SOX10 and Pax3
Fig. 4. Effect of the EDNRB antagonist BQ788 on neural crest culturestreated with EDN3.inhibition of differentiation appearance of pigmented cells in cell number and induced differentiation as can be seen by thedays during which there is a massive increase
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