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Identification of BACE2 as an avid ß-amyloid-degrading protease

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Figure

Figure 1 Overview and outcome of functional screening for novel Aß-lowering proteases
Figure 2 BACE2 degrades Aß in vitro. A, Percent Aß remaining following incubation with different concentrations of recombinant BACE2 forvarious lengths of time
Figure 3 Determination of peptide bonds within Aß hydrolyzed by BACE2.absent and replaced by Aß34
Figure 4 Overexpression of BACE2 in cells yields Aß fragments identical to those produced in vitro
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