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STAT3 enhances the constitutive activity of AGC kinases in melanoma by transactivating PDK1

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Fig. 1 STAT3β negatively regulates PKC phosphorylation and PDK1 expression. Protein extracts from SW1 cells stably transfected with STAT3β or empty vector (−) were blotted with P‑PKC and PKCβII antibodies (a) and PDK1 antibodies (b)
Fig. 2 Silencing of STAT3 reduced PDK1 expression. a Activation of STAT3 in melanoma cell lines
Fig. 3 STAT3 silencing reduced PKC, Akt, and SGK phosphorylation. Protein extracts from WM9 and UACC903 cells described in Fig
Fig. 4 Flow Cytometry analysis of total and activated PKC and Akt upon STAT3 silencing
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