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Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer

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Academic year: 2020

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Figure

Figure 1. The structure design of the PPF (Pyro-PKM Linker-Folate, molecular weight of 1800 g/mol)
Figure 2. The radiolabeling procedure, quality control and stability of 64Cu-PPF. a) The scheme of the 64Cu-radiolabeling of Pyro-Conjugates, b) quality control of 64Cu-labeled PPF by radio-UPLC, c) in vitro stability of 64Cu-Pyro-Conjugates in saline or s
Figure 3. The in vitro stability of 64Cu-pyropheophorbide-a conjugates in saline (a) and serum (10% FBS) (b) was measured by radio-UPLC with UV 410 nm channel and radioactivity channel
Figure 4. The metabolic stability of 64Cu-PPF in urine was measured by radio-UPLC with UV 410 nm channel and radio-activity channel at 1 h post injection

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