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Reduction of microglial activity in a model of multiple sclerosis by dipyridamole

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Academic year: 2020

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Figure

Figure 1 Nontoxic concentrations of dipyridamole reduceTNF-α levels and phagocytic capacity of activated microglia.(A) An ATP luminescence assay demonstrates that dipyridamole doesnot adversely affect viability to at least 20 μM
Figure 2 The increase of multiple cytokines and chemokines following LPS or PAM activation of microglia is attenuated bylevels of all inflammatory molecules, and all were attenuated by dipyridamole (20dipyridamole
Figure 3 Transformation of activated microglia to an amoeboid form was reduced when microglia under basal culture conditions orstimulated with 100 ng/ml LPS were exposed to dipyridamole for 2 days
Figure 4 Dipyridamole reduces clinical and histological scores of EAE. (A)(* Clinical scores were reduced by 100 mg/kg dipyridamoleP < 0.05) (n = 8 per group, mean ± SEM)
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