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Achaete scute-like 2 suppresses CDX2 expression and inhibits intestinal neoplastic epithelial cell differentiation

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Figure

Figure 1: Ascl2 knockdown in CRC cell lines increased expression of goblet cell specific genes
Figure 2: Ascl2 knockdown in CRC cell lines increased CDX2 expression. A. and B. Inhibition of Ascl2 in HT-29 and LS174T cells led to significant increase in CDX2 mRNA levels which were quantitated by real-time PCR analysis twice, each in triplicate (n = 6
Table 1: The primer sequences used in the each CDX2 promoter fragment
Figure 3: Transcriptional regulation of human CDX2 by Ascl2. A. A schematic representation of the human CDX2 promoter constructs used in this study
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