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Computational investigations of cognitive impairment in Huntington's Disease

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Figure

Fig. 1. Architecture of the basal ganglia. Not all connections are presented. Left: simplified situation in pHD with the degraded D2-pathway
Fig. 2. Simplified basal ganglia network to address the consequences of loss of the D1- and D2-pathways
Table 1. Results of flanker simulation with compensation via hyperdirect pathway. The stages of HD pathology are tentative, but the sequence follows the progressive loss of the
Fig. 6 (left panel) shows the distribution of first-order differences at three levels of the HD progression
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