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Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis

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Academic year: 2020

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Figure

Figure 1: Effect of PA and MA in TG levels and ceramide species. PMH were incubated with PA, MA or OA and the combination PA plus MA (PM) and PA plus OA (PO) at 0.5mM overnigh
Figure 2: Effect of PA and MA in hepatocyte lipoapoptosis. PMH were treated with PA, MA and combination PA plus MA (PM) and cells were examine by phase contrast and staining with propidium iodide (PI) or Hoëscht A
Figure 3: Effect of the antioxidant BHA and the SPT inhibitor myriocin in PA and PA plus MA-induced reactive oxygen species and cell death
Figure 4: ER stress induction by PA and PA plus MA and the effect of TUDCA. PMH were treated with PA and PA plus MA (0.5mM) to determine the expression of ER stress markers at 6 hr A
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