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PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation

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Figure

Figure 1: In silico analysis of PARP1 mRNA expression using R2 analysis software on datasets of non-malignant brain tissues of cerebral cortex and cerebellum (grey), versus datasets of childhood ependymoma, medulloblastoma and high grade glioma (dark grey)
Figure 2: Kaplan Meier survival curves using R2 analysis software showing the overall survival probability for high (black) versus low (grey) PARP1 mRNA expression, in patients with medulloblastoma, ependymoma and high grade glioma respectively
Figure 4: Immunoblot of baseline PARP1 (113 kD) and beta actin (42 kD) expression in pediatric brain tumor cell lines
Figure 6. (A) Clonogenic survival of Res196 cells 10 days after irradiation (0 – 6 Gy)

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