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Bedaquiline, an FDA approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem like cancer cells (CSCs)

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Figure

Figure theclass1. Bedaquiline: Structure and Activity.Bedaquiline, also known as TMC207 and R207910, is a first‐in‐ diaryl‐quinoline compound, that mechanistically inhibits bacterial ATP‐synthase. 
Figure  Respiration (basal and  asBedaquiline for well was 48 as  employedhours. ATP  greatlylevels, (A)  p<0.00001. toA  were****  linedetermine diminishes graph significantly ofp<0.0001,  the 3 oxygen  independentmitochondrial decreased. consumption  experiments*** function  maximal),  inXF96  ofMCF7 MCF7 10 analyzer μ 2. breast cellsM)   treatedis  cancershown. (B, with  cells. bedaquiline TheC,  Seahorse  (1D)μMand 
Figure 3. Bedaquiline greatly diminishes glycolysis in   MCF7 breast cancer cells. The Seahorse XF96
Figure 5. Bedaquiline augments oxygen consumption in  normal human fibroblasts. The Seahorse XF96

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