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Keeping a lid on nodal : transcriptional and translational repression of nodal signalling

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Academic year: 2020

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Figure

Figure 1. Schematic of maternal sqt/nodal RNA expression in early zebrafish embryos. Sqt RNA localizes by the four-cell stage in one or two cells, which later formdorsal progenitors, marked by nuclear b-catenin and gsc expression.
Figure 2. Schematic of sqt DLE sequence and structure motif. (ing), which includes a single-stranded motif (pink box) and a short stem-loopstructure
Figure 3. Schematic of zebrafish ybx1 and sqt/nodal mutant phenotypes. Inexpanded yolk syncytial layer (YSL)
Figure 4. Model of translational repression of Nodal pathway components. (a) In early zebrafish embryos, Ybx1 represses squint/nodal translation by binding to thetranslation pre-initiation complex proteins and the squint DLE (solid blue box)

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