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N -acetylcysteine negatively regulates Notch3 and its malignant signaling

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Figure

Figure 1: NAC decreases protein levels of Notch3, but not Notch1. A. Time- and dose-dependent inhibition of NAC on the intracellular domain of Notch3 (N3IC), but not Notch1 (N1IC)
Figure 2: NAC inhibits Notch3 downstream signaling. A. NAC treatment (2-10 mM, 0-24 h) decreases Hes1 and HRT1 protein levels in HeLa cells
Figure 3: The NAC-induced decrease in Notch3 levels depends on lysosome-, but not proteasome-mediated proteolysis
Figure 4: NAC-mediated Notch3 down-regulation is independent of ROS. A. SOD or catalase treatment does not affect N3IC protein levels
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