Original Article The interaction of SS18 and β-catenin promotes tumorigenesis of synovial sarcoma

The negative effect of sFRP3 transfection on β-catenin nuclear translocation and the expression of c-myc and cyclin D1 in MDA-MB-231 cells; the positive effect of

MiR-1229 upregulation promoted cell proliferation in breast cancer both in vitro and in vivo , and activated Wnt/β-catenin signaling by directly targeting GSK-3β, APC,

(D) The protein levels of EFEMP2, EMT markers (E-cadherin and N-cadherin) and Wnt/β-catenin signaling pathway related targets (β-catenin, c-Myc and cyclin D1) in EFEMP2-silencing

Wnt3a and β-catenin expression was significantly lower and GSK-3β expression was significantly higher in the cells exposed to eribulin and transfected with

Our results validated such reports as capsaicin mediated inhibition of β-catenin and TCF-1 signal further inhibited c-Myc and cyclin D1, leading to apoptosis in

(D) Western blot analysis showed a remarkable decrease in the level of nuclear β-catenin and its target gene (Cyclin D1, c-Myc) expression in U251 cells transduced with

Overexpression of ZNRF3 inhibited cell growth and attenuated the tumor-promoting effects of miR-146a via inhibition of GSK-3β/β-catenin signaling, indicating that miR-146a may

and enters the nucleus. In the nucleus, β-catenin binds to T cell transcription factor TCF/NGer factor LEF, and activates Cyclin D1 and C-myc gene expression to promote