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Magnetic Resonance Techniques in Neurodegenerative Diseases First Course Alzheimer s disease and frontotemporal lobar degeneration spectrum

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Magnetic Resonance Techniques

in Neurodegenerative Diseases

First Course

Alzheimer’s disease and frontotemporal lobar degeneration spectrum

SCIENTIFIC PROGRAM

CME ACCREDITED COURSE

Milan, 25-26 November 2013

San Raffaele Scientific Institute

Neuroimaging Research Unit

Institute of Experimental Neurology, Division of Neuroscience,

San Raffaele Scientific Institute and Vita-Salute San Raffaele University

Università Vita-Salute San Raffaele

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ORGANIZING SECRETARIAT

Biomedia srl – Silvia Terragni Via L. Temolo 4 – 20126 Milano Tel. 02/45498282 - Fax 02/45498199 e-mail: silvia.terragni@biomedia.net

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Magnetic Resonance Techniques in Neurodegenerative Diseases - First Course

Milan, 25-26 November 2013 1

F. Agosta (Milan, Italy) P. Bosco (Brescia, Italy) C. Caltagirone (Rome, Italy)

E. Canu (Milan, Italy) S. F. Cappa (Milan, Italy) G. Chetelat (Caen, France)

G. Comi (Milan, Italy) B. Dubois (Paris, France)

A. Falini (Milan, Italy) M. Filippi (Milan, Italy)

N. Fox (London, UK)

K. A. Josephs (Rochester, MN, USA) E. Karran (Cambridge, UK) D. M. Mann (Manchester, UK)

M. Musicco (Rome, Italy) P. Nestor (Magdeburg, Germany)

A. Padovani (Brescia, Italy) J. D. Rohrer (London, UK) F. Valtorta (Milan, Italy) B. N. Van Berckel (Amsterdam, NL)

M. P. Wattjes (Amsterdam, NL)

FACULTY MEMBERS

MAGNETIC RESONANCE TECHNIQUES IN

NEURODEGENERATIVE DISEASES

First Course

Alzheimer’s disease and frontotemporal lobar degeneration spectrum

Milan, 25-26 November 2013

SCIENTIFIC DIRECTION: M. Filippi A. Falini G. Comi SCIENTIFIC SECRETARIAT: F. Agosta G. Magnani ORGANIZING SECRETARIAT: G. Nyitrai L. Zonca

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Monday, 25 November

09.00-09.15 Welcome and program overview

G. Comi (Milan, Italy), M. Filippi (Milan, Italy), A. Falini (Milan, Italy)

09.15-12.45 THE AMYLOID CASCADE AND ALZHEIMER’S DISEASE:

HYPOTHESIS OR THEORY?

SESSION I

CHANGING DIAGNOSTIC CONCEPTS OF ALZHEIMER’S DISEASE I: GENETICS AND CLINICAL FEATURES

Chairs: G. Comi (Milan, Italy), F. Valtorta (Milan, Italy)

09.15 The genetics of Alzheimer’s disease

E. Karran (Cambridge, UK)

09.45 The new lexicon for Alzheimer's disease

B. Dubois (Paris, France), M. Musicco (Rome, Italy)

10.45 Coffee break

SESSION II

CHANGING DIAGNOSTIC CONCEPTS OF ALZHEIMER’S DISEASE II: NEUROIMAGING

Chairs: M. Filippi (Milan, Italy), D. M. Mann (Manchester, UK)

11.15 Amyloid imaging: diagnostic paradigm shift or limited clinical role?

B. N. Van Berckel (Amsterdam, NL)

11.45 Alzheimer’s disease pattern of atrophy measures in clinical practice

A. Falini (Milan, Italy)

12.15 Advanced MR techniques to study neurodegeneration in Alzheimer’s disease

E. Canu (Milan, Italy)

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Magnetic Resonance Techniques in Neurodegenerative Diseases - First Course

Milan, 25-26 November 2013 3

Monday, 25 November

14.15-17.45 MECHANISMS OF NEURODEGENERATION IN FTLD:

THE RELEVANCE OF HUMAN CORTICAL CONNECTIVITY

SESSION III

UNRAVELLING FTLD: LESSONS FROM COGNITIVE NEUROSCIENCE, PATHOLOGY AND GENETICS

Chairs: N. Fox (London, UK), K. A. Josephs (Rochester, MN, USA)

14.15 Behavioural profile and language deficits in FTLD spectrum

S. F. Cappa (Milan, Italy)

14.45 Neuropathological and genetic heterogeneity of FTLD

D. M. Mann (Manchester, UK)

15.15 FTLD pathology targets large-scale human brain networks

J. D. Rohrer (London, UK)

15.45 Afternoon tea

SESSION IV

ASSESSING NEURODEGENERATION USING BRAIN NETWORK ANALYSIS IN FTLD SYNDROMES

Chairs: J. D. Rohrer (London, UK), M. P. Wattjes (Amsterdam, NL)

16.15 Structural brain connectivity in FTLD

P. Nestor (Magdeburg, Germany)

16.45 Functional brain connectivity in FTLD

F. Agosta (Milan, Italy)

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09.00-13.30 THE MISSING TARGETS IN DEMENTIA PREVENTION

SESSION V

CAN WE PREVENT DEMENTIA? IMAGING BIOMARKERS FOR CLINICAL TRIALS IN EARLY DEMENTIA

Chairs: C. Caltagirone (Rome, Italy), P. Nestor (Magdeburg, Germany)

09.00 Wet biomarkers

A. Padovani (Brescia, Italy)

09.30 Imaging of dementia: moving towards prevention

N. Fox (London, UK)

10.00 MR biomarkers for subject selection and monitoring treatment effects in

Alzheimer’s disease trials

M. P. Wattjes (Amsterdam, NL)

10.30 Infrastructures to foster drug discovery and monitoring in Alzheimer’s disease

P. Bosco (Brescia, Italy)

11.00 Coffee break

11.30 MR biomarkers as risk-detectors for Alzheimer’s disease

in cognitively normal individuals

G. Chetelat (Caen, France)

12.00 Imaging biomarkers for clinical trials in FTLD

K. A. Josephs (Rochester, MN, USA)

12.30 MR techniques in Alzheimer’s disease and FTLD:

where we are, what we need and where we are going

M. Filippi (Milan, Italy)

13.00 Concluding remarks

G. Comi (Milan, Italy)

13.30-14.30 Farewell cocktail

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Magnetic Resonance Techniques in Neurodegenerative Diseases - First Course

Milan, 25-26 November 2013 5

General Information

REGISTRATION

Registration is free and includes admission to scientific sessions, conference materials, coffee breaks, lunch and certificate of attendance.

HOW TO REGISTER

All participants are kindly recommended to register via the online registration form at www.biomedia.net

CONTINUING MEDICAL EDUCATION (ECM only for Italian participants)

The event addresses to the disciplines of Neurology, Neurophysiopathology, Neuroradiology. In order to obtain credits, participants must attend the full educational programme (100% of the meeting) and pass the final learning test available on line on the site www.providerecm.it.

CERTIFICATE OF ATTENDANCE

A certificate of attendance will be available to each participant at the end of the meeting

OFFICIAL LANGUAGE

English. Simultaneous translation service is not provided.

HOTEL ACCOMMODATION

In case of accomodation please contact: Biomedia Travel di Biomedia srl Via L. Temolo, 4 – 20126 Milano

Tel.: 02/45498282 - Fax: 02/45498199 - e-mail: biomediatravel@biomedia.net

CONGRESS VENUE

San Raffaele Scientific Institute - Aula Caravella Pinta Via Olgettina, 58 - 20132 Milano, Italy

HOW TO REACH THE VENUE

 Motorways: San Raffaele Congress Centre can be reached by all motorways, following the direc-tion "Tangenziale Est" (East ring road) till Cascina Gobba exit.

 Subway: San Raffaele Congress Centre is connected to Milan by green subway line. The subway stop is Cascina Gobba.

 Railway: Milano Central Railway Station is connected to San Raffaele Congress Centre by subway (green line).

 Airports: Malpensa Airport (50 km) and Linate Airport (5km) are connected to San Raffaele Congress Centre by railway, bus or taxi.

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Magnetic Resonance Techniques

in Neurodegenerative Diseases

First Course

Alzheimer’s disease and frontotemporal lobar degeneration spectrum

Milan, 25-26 November 2013

References

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