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LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target

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Figure

Figure 1. NR1H3fluorescence (IF) staining in non-AMD and AMD donors. Arrowheads point to NR1H3 staining, red
Figure 2. The LXR pathway is biologically active in AMD-vulnerable cells. (multiple comparisons
Figure 3. LXR activation differentially ameliorates oxidant injury and lipid overload in a ligand-dependent manner
Figure 4. Loss of Nr1h3 in vivo compromises visual function. Averaged ERG responses from 10- to 14-month-old dark-adapted WT, Nr1h3–/–, Nr1h2–/–, and Nr1h3–/– Nr1h2–/– mice
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