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Structure and Function Relationships between ATPase Family, AAA Domain Containing Protein 5, Proliferating Cell Nuclear Antigen, and USP1-Associated Factor 1

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Figure

Figure 1. Structure of native human PCNA (PDB ID: 1W60). Each monomer is coloured differently
Figure 2. Sequence alignment of human proteins containing PIP boxes. The consensus sequence is shown with the alignment, where x being any amino acid, ψ being the hydrophobic residues L, M, or I and ϑ being the aromatic residues F or Y
Figure 3.  PCNA ubiquitination is regulated by the RAD6 pathway and the UAF1-USP1. A) PCNA is monoubiquitinated through the Rad6 pathway and deubiquitinated through the recruitment of the UAF1-USP1 deubiquitinase (DUB) complex
Figure 4. Schematic of ATAD5 and UAF1. A) Schematic diagram of ATAD5 with PCNA-interacting Protein (PIP) Box and sumo-interacting protein motif (SIM) coloured green and yellow respectively
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