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Fluhrer, Regina (2003): Zwei neuartige Aspartylproteasen BACE-1 und BACE-2: Charakterisierung und Vergleich der katalytischen Spezifitäten bei der Proteolyse des Alzheimer beta-Amyloid Vorläufer Proteins. Dissertation, LMU München: Fakultät für C

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Figure

Fig. 1 Stable expression of BACE-1 and BACE-2 in HEK 293 cells.(a) Schematic of BACE-2 showing the epitope of antibody 7524
Fig. 2 BACE-2 matures by complexexpressing BACE-1 or BACE-2 were pulse labeled with [ N-glycosylation
Fig. 4 BACE-2 cleaveswere precipitated with antibody 6687 from cell lysates (upper andlower panel)
Fig. 5 BACE-2 selectively reduces the generation of AGlu11. (a) Cells were labeled for 4 h with [b starting at35S]methionine and condi-tioned media were precipitated with antibody 3926 recognizing the Abdomain of bAPP
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