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Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus

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Academic year: 2020

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Figure

Figure 1 Schematic diagram of the primary sequence of IAPP.Notes: Black circles indicate the cysteine amino acid C2–C7 disulfide bond
Figure 2 List of genetic mutations of IAPP determined from in silico studies, and naturally occurring (eg, S20G) mutations.Notes: Sequence alignment between mutants and wild-type IAPP revealed the effect of single-point mutations (S20G, F15L, Y37L, F23L, G
Figure 3 Alignment of IAPP amino acid sequences from different species.Notes: Amino acid sequences of the N-terminus and C-terminus are conserved, but region 20–29 is species specific
Figure 4 demonstrates how pro-IAPP decomposes into

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