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Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

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Academic year: 2020

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Figure

Figure 1. Epigenetic downregulation of RASAL3 data sets. Data represent mean ± SD. *in prostatic CAF
Figure 2. Ras activation stimulates macropinocytosis in prostatic fibroblasts and potentiates growth of adjacent epithelial
Figure 3. Ras activation in CAF drives glutamine metabolism in epithelia. (glutamine-free media (CWR22Rv1 cells treated with NAF or CAF CM for 72 hours prior to metabolome analysis (to aspartate, oxidized GSH, and GSH reduced in CWR22Rv1 cells incubated wi
Figure 4. Stromal-derived glutamine induces mitochondrial bioenergetics and PCa neuroendocrine differentiation
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