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Inhibition of DNA methyltransferase 1 increases nuclear receptor subfamily 4 group A member 1 expression and decreases blood glucose in type 2 diabetes

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Academic year: 2020

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Figure

Figure 1: NR4A1 mRNA was downregulated in patients with T2D. mRNA from 94 patients with T2D and 98 normal controls was used for qRT-PCR
Table 1: Top 10 significant differentially hypermethylated genes in human T2D versis CTL
Figure 3: ATA decreased blood glucose levels in T2D model mice. Sixteen-week-old mice were treated with ATA daily, and blood glucose was measured after 2 weeks.
Figure 5: DNMT1 expression was inhibited by ATA in the pancreas. A. Immunocytochemical staining of pancreas tissues showing DNMT1 protein expression in yKK mice

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