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Chronic FLT3 ITD signaling in acute myeloid leukemia is connected to a specific chromatin signature

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Figure

Figure 1. FLT3-ITD+ AML Displays a Characteristic mRNA Expression Profile(A) PCR amplification of the transmembrane coding region of the FLT3 gene used to identify ITD mutations
Figure 2. FLT3-ITD Consistently Deregu-
Figure 3. FLT3-ITD+ AML Has a Characteristic Chromatin Signature
Figure 5. ITD-Specific DHSs Have a Specific Motif Signature and Bind RUNX1(A) Result of de novo motif search of 1,216 ITD-specific DHSs using HOMER.(B and C) Alignment of ITD-specific DHS motifs with distal DHSs present in either ITD1 or PBSCs (B) with the rol
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