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Structure based design of a eukaryote selective antiprotozoal fluorinated aminoglycoside

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Figure

Table 2. Inhibitory activities of the parent sisomicin and 6’-F sisomicin against prokaryote (MIC) and eukaryote (EC50)
Table 3. Crystallization conditions.
Figure 1. Secondary structures of the bacterial and protozoal cytoplasmic A-sites (R = A or G, Y = C or U, N-N = Watson-Crick base pair)
Figure 3.  Pseudo base-pairs between the 1408 nucleobase in the prokaryotic (A1408) and eukaryotic cytoplasmic (G1408) A-sites and ring I of sisomicin and 6’-OH sisomicin observed in crystal structures (PDB-ID = 4F8U and 4GPX) or computationally modeled st

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