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Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1

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Figure

Figure 1 The SorL1 cytoplasmic tail contains multiple putative kinase recognition motifsthree for CK2 [S/T XX E/D] at 2167, 2187, 2206 (
Figure 2 SorL1 is a phosphoprotein. Wt MEFs were grown to confluency and equal concentrations of protein lysate were incubated with (+)or without (-) calf intestine alkaline phosphatase (CIP)
Figure 4 SorL1 interacts with ROCK2. A. Endogenous SorL1 was immunoprecipitated from Wt MEFs using a SorL1 antibody (BD biosciences)or control IgG
Figure 5 Inhibition of ROCK2 increases Ab40 and Ab42 generation. A. N2A APPSweΔ9PS1 cells were grown to confluency and treated withvehicle or 100 nM RL-1 for 60 mins

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