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Characterization of EDP-305, a Highly Potent and Selective Farnesoid X Receptor Agonist, for the Treatment of Non-alcoholic Steatohepatitis

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Figure

Table 1. Experimental EC50 values and efficacy for compounds on chimeric FXR reporter activation in CHO cells
Figure 1. EDP-305 is a potent FXR agonist. A. The FXR was activated with increasing concentrations of the indicated compounds in CHO cells (left panel) and in HEK293 cells (right panel)
Figure 2. EDP-305 regulates triglyceride metabolism in vitro. Effects of EDP-305 (50 nM) or OCA (500 nM), at concentrations near their respective EC50, on mRNA levels of SCD1 (A), CD36 (B), and DGAT2 (C) in Huh7.5 cells
Figure 3. EDP-305 favorably regulates lipoprotein metabolism in vitro and in vivo. A. Effects of EDP-305 (50 nM) or OCA (500 nM), at concentrations near LDLR in Huh7.5 cells treated with EDP-305 (50 nM) or OCA (500 nM) for 32 hr
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