PhD School of Molecular Metabolism and
Danish Cardiovascular Research Academy
PhD Course on “Molecular Mechanisms in the Metabolic Syndrome” - 3 ECTS
Time: 29 October – 1 November 2007
Place: Trinity Hotel and Conference Center A/S, Fredericia, Denmark
Topics:
- Basic molecular and pathophysiological aspects of insulin resistance - Multiphase consequences of insulin resistance and hyperinsulinaemia - Biochemical role of obesity
- The basic biochemistry of the atheromatous vascular disease
- Development of and the disordered kinetics of the dislipidaemia in vascular disease - Pathophysiology of hypertension and its relationship to the development of the syndrome - Biochemical and metabolic impact of glucose intolerance
- The clinical and the therapeutic implications arising out of the above pretentions will be stressed throughout the course.
Prerequisites: PhD candidates in Diabetes, Endocrinology, Cardiology and Higher Physician training, as a postgraduate segment towards their PhD degree.
Registration: Registration form can be found at www.metabolism-phd.dk and must be forwarded to the Secretariat of the PhD School of Molecular Metabolism no later than 7 September 2007 (tine.christensen@ouh.regionsyddanmark.dk)
Price: 7,000 DKK. PhD and pre-graduate medical students free of charge.
PhD School of Molecular Metabolism and
Danish Cardiovascular Research Academy
PhD Course:
Molecular Mechanisms in the Metabolic Syndrome
29 October (Monday) – 1 November (Thursday) 2007
Programme
DAY 1: Monday 29 October 2007
9.00 – 9.30 a.m. Registration and refreshments
9.30 – 9.40 a.m. Welcome & Intro HBN
SESSION I THE METABOLIC SYNDROME
Chair person: Henning Beck-Nielsen
9.40 – 10.20 a.m. The Metabolic Syndrome (MS):
Definition, clinical features and metabolic “costs” in 2007.
HBN
10.20 – 10.30 a.m. Discussion
Workshop:
10.30 – 12.30 a.m. Insulin resistance – what is it and how do we measure it?
JEH/OHN
A. The “Clamp technique” (including indirect
calorimetry, glucose turnover measurements, glucose processing invivo and muscle biopsy procedure) (10.30-11.30 and 11.30-12.30)
B. Surrogate measurements: Fasting plasma insulin,
12.30 – 1.30 p.m. Lunch
1.30 – 2.10 p.m. The normal glucose and fat metabolism NF/JK
2.10 – 2.20 p.m. Discussion
2.20 – 3.00 p.m. Molecular/Biochemical basis of insulin resistance. KH
3.00 – 3.10 p.m. Discussion
3.10 – 3.50 p.m. Mitochondrial function and insulin resistance MM
3.50 – 4.00 p.m. Discussion
4.00 – 4.30 p.m. Coffee/tea break
SESSION II EPIDEMIOLOGY OF MS; GENOME AND MS;
THE LIVER AND MS; SKELETAL MUSCLE AND MS
Chair person: Kurt Højlund
4.30 – 5.10 p.m. The liver and its role in the metabolic syndrome OHN
5.10 – 5.20 p.m. Discussion
5.20 – 6.10 p.m. Non-alcoholic fatty liver (NAFL) and insulin
resistance
HYJ
6.10 – 6.20 p.m. Discussion
DAY 2: Tuesday 30 October 2007
Chair person: Bjørn Richelsen
8.30 – 9.10 a.m. The epidemiology of the metabolic syndrome KBJ
9.10 – 9.20 a.m. Discussion
9.20 – 10.00 a.m. The genome and the metabolic syndrome TH
10.00 -10.10 a.m. Discussion
10.10 – 10.40 a.m. Coffee/tea break
10.40 – 11.20 a.m. Obesity and its role in the development of the MS. BR
11.20 – 11.30 a.m. Discussion
11.30 – 12.10 The adipocytokines (Leptin, adiponectin, TNFalpha) BR
12.10 – 12.20 Discussion
12.20 – 1.30 p.m. Lunch
SESSION III THE ROLE OF EXERCISE
Chair person: Jørgen Wojtaszewski
1.30 – 2.10 p.m. The role of skeletal muscle in the metabolic syndrome KH
2.10 – 2.20 p.m. Discussion
2.20 – 3.00 p.m. The signalling cascade for energy supply in exercising skeletal muscle of normal and insulin resistant
subjects.
3.00 – 3.10 p.m. Discussion
3.10 – 3.50 p.m. Exercise as “medicine” FD
3.50 – 4.00 p.m. Discussion
4.00 – 4.30 p.m. Coffee/tea break
SESSION IV FFA AND PPARS
Chair person: Susanne Mandrup
4.30 – 5.10 p.m. I. The PPAR system in fat metabolism. SM
5.10 – 5.20 p.m. Discussion
5.20 – 6.00 p.m. II. The PPAR system – a clinicopathological
perspective.
HBN
6.00 – 6.10 p.m. Discussion
DAY 3: Wednesday 31 October 2007
SESSION V ENDOTHELIAL FUNCTION
Chair person: Christian Torp Pedersen
8.30 – 9.10 a.m. Lipoprotein lipase (LPL) and lipid turnover – the
importance of LPL to the metabolic syndrome and cardiovascular diseases
FLH
9.10 – 9.20 a.m. Discussion
9.20 – 10.00 a.m. Interleukin-6 – inflammation, insulin resistance and
exercise: its role in the metabolic syndrome
BK
10.00 -10.10 a.m. Discussion
10.10 – 10.40 a.m. Coffee/tea break
10.40 – 11.20 a.m. Endothelial function and the metabolic syndrome CRM
11.20 – 11.30 a.m. Discussion
11.30 – 12.10 Endothelial function and cardiovascular disease CTP
12.10 -12.20 Discussion
12.20 – 1.30 p.m. Lunch
SESSION VI DYSLIPIDAEMIA
Chair person: Børge Nordestgaard
1.30 – 2.10 p.m. I. Dyslipidaemia – lipid turnover and its implication
for insulin resistance.
BN
2.20 – 3.00 p.m. II. Dyslipidaemia – implications for the development of atherosis and vascular disease.
BN
3.00 – 3.10 p.m. Discussion
3.10 – 3.50 p.m. Metabolic syndrome in the cardiovascular clinic PH
3.50 – 4.00 p.m. Discussion
4.00 – 4.30 p.m. Coffee/tea break
4.30 – 5.10 p.m. Evidence based management of dyslipidaemia in the
metabolic syndrome: How relevant are targets to outcomes?
HSH
5.10 – 5.20 p.m. Discussion
5.20 – 6.00 p.m. The prenatal/intrauterine environment in the
development of the metabolic syndrome and arteriosclerosis
PP
6.10 – 6.20 p.m. Discussion
DAY 4: Thursday 1 November 2007
SESSION VII HYPERTENSION AND MS
Chair person: Henning Beck-Nielsen
8.30 – 9.10 a.m. Hypertension and the metabolic syndrome CB
9.10 – 9.20 a.m. Discussion
9.20 – 10.00 a.m. PCOS and the MS – insulin resistance and
dyslipidaemia
DG
10.00 – 10.10 a.m. Discussion
10.10 – 10.40 a.m. Coffee/tea break
10.45 – 12.15 Workshop/seminar
Newer techniques in defining the dysmetabolic signalling cascades in the metabolic syndrome: 1) Proteomics 2) Transcriptomics 3) Lipidomics 4) Bioinformatics ML QT JK SB
12.15 – 12.30 Questions to the entire course curriculum HBN
FACULTY Henning Beck-Nielsen (HBN)
Course leader
Professor of Medicine Dept. of Endocrinology Odense University Hospital DENMARK Henning.beck-nielsen@ouh.regionsyddanmark.dk Sten Christensen (SC) Course leader Professor Dept. of Pharmacology University of Copenhagen DENMARK Sten.christensen@farmakol.ku.dk
Christian Berne (CB) Professor
Endocrinology and Diabetes section The Uppsala Academic Hospital SWEDEN
Christian.berne@akademiska.se
Knut Borch-Johnsen (KBJ) Professor, Chief physician
Steno Diabetes Center Copenhagen
DENMARK
kbjo@steno.dk
Søren Brunak (SB) Professor
Biocentrum
Technical University of Denmark Kgs. Lyngby
DENMARK
brunak@cbs.dtu.dk
Flemming Dela (FD) Professor, DMSc
Dept. of Medical Physiology Panum Institute
University of Copenhagen DENMARK
Fdela@mfi.ku.dk
Nils Færgeman (NF) Associate Professor
Dept. of Biochemistry and Molecular Biology University of Southern Denmark
DENMARK
Nils.f@bmb.sdu.dk
Dorte Glintborg (DG) MD, PhD
Henrik Steen Hansen (HSH) Associate professor, MD, DMSc Dept. of Cardiology
Odense University Hospital DENMARK
Henrik.steen.hansen@ouh.regionsyddanmark.dk
Torben Hansen (TH) MD
Steno Diabetes Center Copenhagen
DENMARK
toha@steno.dk
Per Hildebrandt (PH) Head of department, Chief physician, DMSc
Clinical Research Unit, Dept. of Cardiology and Endocrinology E
Frederiksberg Hospital DENMARK
Per.hildebrandt@fh.hosp.dk
Jan Erik Henriksen (JEH) MD, PhD
Dept. of Endocrinology Odense University Hospital DENMARK
Jan.erik.henriksen@ouh.regionsyddanmark.dk
Finn Lund Henriksen (FLH) MD, PhD
Dept. of Cardiology
Odense University Hospital DENMARK
f.l.henriksen@dadlnet.dk
Ole Hother-Nielsen (OHN) DMSc
Dept. of Endocrinology Odense University Hospital DENMARK
Ole.hother-nielsen@ouh.regionsyddanmark.dk
Kurt Højlund (KH) MD, PhD
Dept. of Endocrinology Odense University Hospital DENMARK
k.hojlund@dadlnet.dk
Bente Klarlund (BK) Professor
Muscle Research Centre Rigshospitalet
Copenhagen DENMARK
Jens Knudsen (JK) Professor
Dept. of Biochemistry and Molecular Biology University of Southern Denmark
DENMARK
jkk@bmb.sdu.dk
Martin Larsen (ML) Research professor, PhD
Dept. of Biochemistry and Molecular Biology University of Southern Denmark
DENMARK
mrl@bmb.sdu.dk
Christian Rask Madsen (CRM) Research Fellow
Harvard Medical School Joslin Diabetes Center Boston
USA
Christian.rask-madsen@joslin.harvard.edu
Susanne Mandrup (SM) Associate professor
Dept. of Biochemistry and Molecular Biology University of Southern Denmark, Odense DENMARK
s.mandrup@bmb.sdu.dk
Martin Mogensen (MM) MSc, PhD student
Institute of Sports Science and Biomechanics University of Southern Denmark
DENMARK
mmogensen@health.sdu.dk
Børge Nordestgaard (BN) Professor
Department of Clinical Biochemistry Herlev County Hospital
DENMARK
brno@herlevhosp.kbhamt.dk
Christian Torp Pedersen (CTP) Professor
Clinic of Cardiology Y Bispebjerg Hospital DENMARK
ctp@heart.dk
Pernille Poulsen (PP) Post.doc.
Steno Diabetes Center, Gentofte DENMARK
Bjørn Richelsen (BR) Professor
Dept. of Medical Endocrinology Aarhus University Hospital DENMARK
Bjoern.richelsen@as.aaa.dk
Qihua Tan (QT) Assistant professor
Human MicroArray Center Odense University Hospital DENMARK
Qihua.tan@ouh.regionsyddanmark.dk
Jørgen Wojtaszewski (JW) Associate professor
August Krogh Institute University of Copenhagen DENMARK
jwojtaszewski@aki.ku.dk
Hannelei Yki-Järvinen (HYJ) Professor
Department of Medicine University of Helsinki FINLAND
ykijarvi@cc.helsinki.fi
Course secretariat:
PhD School of Molecular Metabolism Research secretary Tine Christensen Odense University Hospital
Dept. of Endocrinology Kloevervaenget 6, 4. 5000 Odense C Denmark Tel. +45 6541 1769 Fax +45 6591 9653 E-mail: tine.christensen@ouh.regionsyddanmark.dk
Web site: www.metabolism-phd.dk/optcour.html - (B2)
Place: Trinity Hotel and Conference A/S, Gl. Færgevej 30, Snoghøj, Fredericia, Denmark
