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Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high fat diet–induced liver steatosis in mice

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Academic year: 2020

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Figure

Figure 1SIRT1 protein levels and NAD
Figure 2DBC1 regulates NAD-dependent SIRT1 activity. (A) Isolated rat liver nuclei extracts were incubated in the absence or presence of 200 μM NAD+, or with NAD+ plus nicotinamide (2 mM), suramin (100 μM), or sirtinol (100 μM), and SIRT1 activity was meas
Figure 3DBC1 controls glucose-dependent SIRT1 activity in human hepatocytes. (
Figure 4SIRT1 and DBC1 interact in mouse tissue, and Dbc1 KO mice show increased endogenous SIRT1 activity in vivo
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