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MTRX1011A, a humanized anti CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase I randomized, double blind, placebo controlled study incorporating pharmacodynamic biomarker assessments

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Academic year: 2020

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Figure

Figure 1 Patient disposition. Single ascending dose and multiple dose stages.
Table 2 Adverse events in ≥2 patients
Figure 2 Peripheral blood T cell levels. Blood CD4 T cells in patients after a single dose (A and C) or 8 weekly doses (B and D) of MTRX1011Ain doses ranging from 0.3 to 7.0 mg/kg
Figure 3 Peripheral blood CD4 expression and CD4 occupancymemory (CD45RA-) CD4 T cells in patients receiving placebo or MTRX1011A in the single dose (A and C) and multiple dose (B and D) phase ofthe study when administered intravenously (IV) or subcutaneou
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