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OX40 signaling is involved in the autoactivation of CD4+CD28− T cells and contributes to the pathogenesis of autoimmune arthritis

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Academic year: 2020

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Fig. 1 Expression of OX40 and its ligand OX40L in patients with RA and CIA mice.significant.arthritis,and CD19expression on immune cells in ( a, c, e Flow cytometry detection of OX40 and OX40La) PB or (e) SF samples of patients with RA, patients with OA, a
Fig. 2 The CD4levels of CD4ian individual subject;(+CD28−OX40+ T-cell subset in patients with RA and CIA mice
Fig. 3 Correlations between CD4arthritis with high disease activity,collagen-induced arthritis,coefficient; *after Dex treatment
Fig. 4 Adoptive transfer in CIA mice. Passive CIA was induced by intravenous transfer of sorted CD4+CD28−OX40− (a, n = 4), CD4+CD28+OX40−(b, n = 4), CD4+CD28−OX40+ (c, n = 5), or CD4+CD28+OX40+ (d, n = 4) T-cell subsets
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