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Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma

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Academic year: 2020

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Figure

Figure 1: PTHrP mRNA levels predict bony invasion and bone destruction in two mouse models
Figure 2: OSCC express PTHrP in a Gli2 dependent manner. A-C. Gli2 inhibition decreases basal PTHrP expression and suppresses TGFβ induced PTHrP expression
Figure S5A), which highlights abnormal Wnt signaling
Figure 4: TGFβ signaling modulates Gli2 and PTHrP expression. A&B. TGFβ signaling increased PTHrP expression.qRT-PCR was used to determine PTHrP mRNA levels of SCC4 and CAL27 cells that were treated with TGFβ or the buffer control
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