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Activin/Nodal signalling maintains pluripotency by controlling Nanog expression

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Figure

Fig. 1. Expression of NANOG in hESCs depends on Activin/Nodal signalling. (directed against SMAD2/3 or NANOG
Fig. 2. Constitutive expression of Nanog is necessary and sufficient to prevent neuroectoderm differentiation of hESCs induced byinhibition of Activin/Nodal signalling
Fig. 3. Knockdown of NANOG expression in hESCs induces the expression of neuroectoderm markers
Fig. 4. Nanog is not sufficient to prevent BMP4-induced extraembryonic differentiation
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