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Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients

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Academic year: 2020

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Figure 1: Characterization of HCC cell lines. A. Protein levels of TGFBR1, TGFBR2, SMAD2, SMAD3, SMAD4, AFP, E-cadherin and Vimentin was detected by Western blot in a panel of cell lines; B
Figure 2: Effects of galunisertib on canonical and noncanonical TGF-β signalling. Protein expression was evaluated by Western blot after cell treatment with 1 and 10 µM galunisertib with or without 5 ng/mL TGF-β; JHH6 A
Figure 3: Antiproliferative and anti-invasive effects of galunisertib. A. Antiproliferative effects of galunisertib with and without TGF-β (5 ng/mL) on a panel of HCC cell lines; B
Figure 4: Cytotoxic effects of the galunisertib/sorafenib combination. A. Relative cell viability after 72 hours exposure to 0.63, 1.25, 2.5, and 5 µM sorafenib with (gray bars) and without (white bars) 5 ng/mL TGF-β of JHH6, SK-HEP1, SK-Sora, HepG2, Hep3B
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