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COMPUTATIONAL ANALYSIS OF G PROTEIN COUPLED RECEPTOR SCREENING, DIMERIZATION, AND DESENSITIZATION

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Figure

Figure 1.1  a) A drug’s view of a receptor.  Using a simplified view of drug–receptorinteractions, the drug can only bind to (kon) and dissociate from (koff) the receptor,selecting for a specific conformation (α)
Figure 1.3  Physiological roles of GPCRs throughout the human body.
Figure 1.4  GPCR signal transduction cascade. First, ligand binds to the receptor andalters is conformation
Figure 1.8  Mechanism of GPCR desensitization.  The active Gβγ is able to recruitreceptor kinase from the cytosol
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