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Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain

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Academic year: 2020

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Figure

Fig. 1. Otx2 is selectively expressed in embryonic post-mitotic and
Fig. 2. Otx2-driven GFP expression confirms Otx2 expression in TH+those of the SN Otx2 and GFP sharply colocalize in THmutants immunostained with Otx2 and TH, GFP and TH, and Otx2 and GFP show thatneurons
Fig. 3. Otx1 is not expressed in VTA neurons.sections of a P75 neurons and no staining for (A-D) TransverseOtx1Cre/Cre mouse immunostained with Otx2 and TH(A,B) and Cre and TH (C,D) show no variation in the number of Otx2+-TH+Otx1-driven Cre activity
Fig. 5I). However, since Girk2 was expressed at a low level alsoin the rest of the VTA, a few Otx2+-Girk2+ neurons could be foundin the central and ventral VTA (Fig
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