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Functional Co-substituted Poly[(amino acid ester)phosphazene] Biomaterials

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Figure 2.1: A diagrammatic representation of the in vitro tissue engineering process; where a cell-seeded scaffold is matured in vitro in a bioreactor prior to implantation into the patient
Figure 2.2: Structures of various polyphosphazenes including steroidal substituents
Figure 2.2 have one type of side chain throughout the entire polymer, although it has
Figure 3.1: The glass vials and stainless steel vial rack that were manufactured in-house for the facile thermal ring opening polymerizations
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Outline

Polymerization to Poly[(dichloro)phosphazene] 13  In Vitro and In Vivo Biocompatibility 21  Biodegradability 23  Macromolecular Substitution of Non-Functional Amino Acid Esters 35  FTIR, 1 H NMR, and 31 P NMR Characterization 58  TGA, DSC, and GPC Characterization 70  TGA, DSC, and GPC Characterization 89  Cytotoxicity and Cell Proliferation on Non-Functional and Functional Two- Future Directions 105 

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