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A multivariate approach to sample size calculations for thorough QT studies

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Figure

Table 1: Sample size calculations for the parallel design
Table 2: Sample size calculations for the crossover design with no random periodeffect (σp = 0)
Table 3: Sample size calculations for the crossover design with no random periodeffect (σp = 4)
Table 4: Sample size calculations for the crossover design given overall σρ with1 = ρ2
+3

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