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The Relationship between Apelin and Angiotensin II in Paroxysmal Supraventricular Tachycardia

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Academic year: 2021

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1 - ،يژﻮﻟﻮﯾﺰﯿﻓ تﺎﻘﯿﻘﺤﺗ ﺰﮐﺮﻣ و قوﺮﻋ و ﺐﻠﻗ هوﺮﮔ ،رﺎﯾدﺎﺘﺳا ﮑﺷﺰﭘ هﺪﮑﺸﻧاد ﯽ ﻠﻀﻓا ﯽ ،رﻮﭘ ناﺮﯾا ،نﺎﻣﺮﮐ ،نﺎﻣﺮﮐ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد 2 - ،رﺎﯿﺘﺳد قوﺮﻋ و ﺐﻠﻗ هوﺮﮔ و ،يژﻮﻟﻮﯾﺰﯿﻓ تﺎﻘﯿﻘﺤﺗ ﺰﮐﺮﻣ ﮑﺷﺰﭘ هﺪﮑﺸﻧاد ﯽ ﻠﻀﻓا ﯽ ،رﻮﭘ ناﺮﯾا ،نﺎﻣﺮﮐ ،نﺎﻣﺮﮐ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد 3 - ،يژﻮﻟﻮﯾﺰﯿﻓ تﺎﻘﯿﻘﺤﺗ ﺰﮐﺮﻣ و يژﻮﻟﻮﯿﻣﺪﯿﭘا هوﺮﮔ ،يﺮﺘﮐد يﻮﺠﺸﻧاد ﮑﺷﺰﭘ هﺪﮑﺸﻧاد ﯽ ﻠﻀﻓا ﯽ ،رﻮﭘ ناﺮﯾا ،نﺎﻣﺮﮐ ،نﺎﻣﺮﮐ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد طﺎﺒﺗرا ﺢﻄﺳ ﻣﺮﺳ ﻠﭘا ﯿ و ﮋﻧآ ﺴﻧﺎﺗﻮ ﯿ II ﺎﺑ ﻪﻠﻤﺣ ﮐﺎﺗ درﺎﮐ ي قﻮﻓ ﻨﻄﺑ ﯽﺟﻮﻨﻬﮐ ﻪﻣﻮﺼﻌﻣ 1 ﯽﻧﺎﻤﺣر ﻪﻤﻃﺎﻓ ، 2 * ﺐﯿﻘﻧ ﺪﻤﺣا ، هداز 3 ﻪﻧﺎﮕﯾ ﻪﺑﻮﺒﺤﻣ ، 4 ﯽﻣﻮﺼﻌﻣ ﺮﺳﺎﯾ ، 4 :ﺖﻓﺎﯾرد ﺦﯾرﺎﺗ 1/ 9/ 95 :شﺮﯾﺬﭘ ﺦﯾرﺎﺗ 14 / 11 / 95 ﺦﯾرﺎﺗ پﺎﭼ : 15 /1 / 96 هﺪﯿﮑﭼ :ﻪﻣﺪﻘﻣ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ و ﻦﯿﻠﭘا ﯽﻣﺮﺳ ﺢﻄﺳ ﯽﺳرﺮﺑ ،ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ مﺎﺠﻧا زا فﺪﻫ II ﯽﮐﺎﺗ ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ رد ﯽﻨﻄﺑ قﻮﻓ يدرﺎﮐ ﻪﻠﻤﺣ ) يا Paroxysmal supraventricular tachycardia ﺎﯾ PSVT دﻮﺑ ( . :ﻪﻌﻟﺎﻄﻣ هﻮﯿﺷ ﯽﻔﯿﺻﻮﺗ عﻮﻧ زا ﺶﻫوﮋﭘ ﻦﯾا - ﻪﮐ دﻮﺑ ﯽﻠﯿﻠﺤﺗ لﺎﺳ رد 1395 .ﺪـﯾدﺮﮔ مﺎـﺠﻧا نﺎﻣﺮﮐ ﺮﻬﺷ رد ﯽﻌﻄﻘﻣ ترﻮﺻ ﻪﺑ ﻪﻧﻮﻤﻧ و ﺖﻓﺮﮔ ترﻮﺻ سﺮﺘﺳد رد شور ﻪﺑ يﺮﯿﮔ ،ﻪﻧﻮﻤﻧ ﻢﺠﺣ لﻮﻣﺮﻓ زا هدﺎﻔﺘﺳا ﺎﺑ 76 ) ﺮﻔﻧ 38 و رﺎﻤﯿﺑ 38 ناﻮﻨﻋ ﻪﺑ ﻢﻟﺎﺳ دﺮﻓ هداد .ﺪﻧﺪﺷ بﺎﺨﺘﻧا (ﺪﻫﺎﺷ هوﺮﮔ ﮏﭼ رد هﺪﻣآ ﺖﺳد ﻪﺑ يﺎﻫ ﺖﺴﯿﻟ مﺮـﻧ رد ﺲﭙـﺳ و ﺪﯾدﺮﮔ ﺖﺒﺛ راﺰـﻓا SPSS و ﻪـﯾﺰﺠﺗ درﻮـﻣ ﺖﻓﺮﮔ راﺮﻗ ﻞﯿﻠﺤﺗ . ﻪﺘﻓﺎﯾ :ﺎﻫ ﯽﻨﻌﻣ توﺎﻔﺗ ﺎﻣا ،دﻮﺑ ﺮﺘﻤﮐ نارﺎﻤﯿﺑ هوﺮﮔ رد ﻦﯿﻠﭘا ﯽﻣﺮﺳ ﺢﻄﺳ ﻦﯿﮕﻧﺎﯿﻣ ) ﺪﺸﻧ هﺪﻫﺎﺸﻣ هوﺮﮔ ود ﻦﯿﺑ يراد 302 /0 = P .( ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ ﯽﻣﺮﺳ ﺢﻄﺳ ﻦﯿﮕﻧﺎﯿﻣ II و ﺖﻓﺎﯾ ﺶﻫﺎﮐ نارﺎﻤﯿﺑ هوﺮﮔ رد ﺰﯿﻧ توﺎﻔﺗ ﻦﯾا ﯽﻨﻌﻣ ) دﻮﺑ راد 003 /0 = P (. ﻪﺠﯿﺘﻧ :يﺮﯿﮔ ﻦﯿـﺑ توﺎـﻔﺗ ﺎـﻣا ،دﻮـﺑ ﺮﺘﻤﮐ نارﺎﻤﯿﺑ هوﺮﮔ رد ﻦﯿﻠﭘا ﯽﻣﺮﺳ ﺢﻄﺳ ﻦﯿﮕﻧﺎﯿﻣ ﻪﮐ ﺪﯾدﺮﮔ ﺺﺨﺸﻣ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ رد هوﺮﮔ ﺪﻫﺎﺷ و رﺎﻤﯿﺑ يﺎﻫ ﯽﻨﻌﻣ ﻪﻧﻮﻤﻧ ﺎﺑ ﺮﺘﺸﯿﺑ تﺎﻘﯿﻘﺤﺗ مﺎﺠﻧا ،ﻪﻨﯿﻣز ﻦﯾا رد .دﻮﺒﻧ راد هدﺮﺘـﺴﮔ ﻪـﻧﻮﻤﻧ ﻢـﺠﺣ و ﺮﮕﯾد يﺎﻫ ﺮﺗ ﻪـﺑ ﺎﯾ ﺖﺳد رﻮﻈﻨﻣ ﯽﻨﻌﻣ توﺎﻔﺗ ﻪﺑ ﻦﺘﻓ ﯽﻣ دﺎﻬﻨﺸﯿﭘ ،راد ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ ﯽﻣﺮﺳ ﺢﻄﺳ ﻦﯿﮕﻧﺎﯿﻣ ،ﻦﯿﻨﭽﻤﻫ .ددﺮﮔ II ﯽﻨﻌﻣ رﻮﻃ ﻪﺑ يراد ﯽﻣ عﻮﺿﻮﻣ ﻦﯾا ﻪﮐ ﺖﻓﺎﯾ ﺶﻫﺎﮐ نارﺎﻤﯿﺑ هوﺮﮔ رد تﺎـﻌﻟﺎﻄﻣ مﺎـﺠﻧا و ﺪﺷﺎﺑ نارﺎﻤﯿﺑ هوﺮﮔ رد ﺮﮐﻮﻠﺑ ﻢﯿﺴﻠﮐ فﺮﺼﻣ زا ﯽﺷﺎﻧ ﺪﻧاﻮﺗ ﯽﻣ دﺎﻬﻨﺸﯿﭘ صﻮﺼﺧ ﻦﯾا رد ﻪﻧﺎﮔاﺪﺟ ددﺮﮔ . :يﺪﯿﻠﮐ تﺎﻤﻠﮐ ﻦﯿﻠﭘا ، ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ II ﯽﮐﺎﺗ ، ﻪﻠﻤﺣ ﯽﻨﻄﺑ قﻮﻓ يدرﺎﮐ يا :عﺎﺟرا ﺐﯿﻘﻧ ،ﻪﻤﻃﺎﻓ ﯽﻧﺎﻤﺣر ،ﻪﻣﻮﺼﻌﻣ ﯽﺟﻮﻨﻬﮐ ﺮـﺳﺎﯾ ﯽﻣﻮﺼﻌﻣ ،ﻪﺑﻮﺒﺤﻣ ﻪﻧﺎﮕﯾ ،ﺪﻤﺣا هداز . طﺎﺒﺗرا ﺢﻄﺳ ﻣﺮﺳ ﻠﭘا ﯿ و ﮋﻧآ ﺴﻧﺎﺗﻮ ﯿ II ﺎـﺑ ﻪﻠﻤﺣ ﮐﺎﺗ درﺎﮐ ي قﻮﻓ ﻨﻄﺑ . ﯽﻠﻀﻓا ﯽﮑﺷﺰﭘ هﺪﮑﺸﻧاد ﯽﻨﯿﻟﺎﺑ تﺎﻌﻟﺎﻄﻣ ﻪﻠﺠﻣ رﻮﭘ 1396 ؛ 2 ) 2 -1 :( 45 -38 . ﯽﺸﻫوﮋﭘ ﻪﻟﺎﻘﻣ

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ﻪﻣﺪﻘﻣ ﯽﮐﺎـــــﺗ ﻪـــــﻠﻤﺣ ﯽـــــﻨﻄﺑ قﻮـــــﻓ يدرﺎـــــﮐ يا )

Paroxysmal supraventricular tachycardia

ﺎــﯾ PSVT ﯽﻤﺘﯾرآ زا ﯽﮑﯾ ،( ﻞـﯾﻻد ﻪـﻠﻤﺟ زا و ﯽﺒﻠﻗ يﺎﻫ ﺲﻧاژروا ﻪﺑ ﻪﻌﺟاﺮﻣ ﻊﯾﺎﺷ ﯽﻣ ﺎﻫ ) ﺪﺷﺎﺑ 1 زوﺮـﺑ ناﺰـﯿﻣ .( دوﺪﺣ ﻪﺿرﺎﻋ ﻦﯾا 35 ﺮـﻫ رد درﻮﻣ 100 رد ﺮـﻔﻧ راﺰـﻫ دوﺪﺣ نآ عﻮﯿﺷ و لﺎﺳ 25 /2 ) ﺖﺳا راﺰﻫ رد 2 عﻮﯿﺷ .( موﺰـﻟ ،نآ زا ﯽـﺷﺎﻧ تﻼﮑـﺸﻣ و ﯽﻤﺘﯾرآ عﻮﻧ ﻦﯾا يﻻﺎﺑ ﻢﺴﯿﻧﺎﮑﻣ ﻪﺑ ﻪﺟﻮﺗ ﺶﯿـﭘ زا ﺶﯿـﺑ ار نآ رد ﻞﯿﺧد يﺎﻫ .ﺖﺳا هداد راﺮﻗ ﺪﯿﮐﺄﺗ درﻮﻣ ﺪـﻧﺮﯿﮔ و ﻦﯿـﻠﭘا ،ﻦﯿـﺑ ﻦﯾا رد ه ) نآ يﺎـﻫ APJ ﻪـﺑ ( ﯽﻣ ﻞﻤﻋ ﻦﯾﺮﮐارﺎﭘ ﺎﯾ ﻦﯾﺮﮐﻮﺗا ﻢﺘﺴﯿﺳ ﮏﯾ ناﻮﻨﻋ ﺪـﻨﮐ ﯽـﻣ ﻢﯿـﻈﻨﺗ ار ﺐـﻠﻗ دﺮـﮑﻠﻤﻋ هﻮﻘﻟﺎﺑ رﻮﻃ ﻪﺑ ﻪﮐ .ﺪـﯾﺎﻤﻧ APJ ﻪﺑ ﻞﺼﺘﻣ هﺪﻧﺮﯿﮔ G ﻪﮐ ﺖﺳا ﻦﯿﺌﺗوﺮﭘ 377 ﺪﯿﺳا ﻪﺑ و دراد ﻪﻨﯿﻣآ Gi ﯽﻣ ﺖﻔﺟ ياﺮـﺑ هﺪـﻧﺮﯿﮔ ﻦـﯾا .دﻮﺷ لﺎﺳ رد رﺎﺑ ﻦﯿﻟوا 1993 ) ﺪﺷ نﻮﻠﮐ 3 .( APJ ﺖﻫﺎﺒـﺷ ــﺑ يدﺎــﯾز عﻮــﻧ هﺪــﻧﺮﯿﮔ ﻪ I ﻦﯿــﺴﻧﺎﺗﻮﯾﮋﻧآ II ﺎــﻣا ،دراد ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ II ﯽﻤﻧ ﻞﺼﺘﻣ نآ ﻪﺑ ﯽـﻌﯿﺒﻃ ﺪﻧﺎﮕﯿﻟ .دﻮﺷ لﺎﺳ رد رﺎﺑ ﻦﯿﻟوا ياﺮﺑ ﻦﯿﻠﭘا 1998 هﺪـﻌﻣ تﺎﺤﺷﺮﺗ زا ) ﺪﯾدﺮﮔ اﺪﺟ وﺎﮔ 4 ﺪـﻨﻠﺑ يوزﺎـﺑ يور ﺮﺑ ﻪﮐ ﻦﯿﻠﭘا نژ .( موزﻮﻣوﺮﮐ X هﺮـﭘ ،ﺖـﺳا ﻪﺘﻓﺮﮔ راﺮﻗ نﺎﺴﻧا ار ﻦﯿﻠﭘاوﺮـﭘ ﻪﮐ 77 ،دراد ﻪﻨﯿﻣآ ﺪﯿﺳا ﯽﻣ ﺪﮐ ﯽﻌﯿﺳو رﻮﻃ ﻪﺑ و ﺪﻨﮐ ﺖﻓﺎﺑ رد ﯽﻣ نﺎﯿﺑ نﻮﮔﺎﻧﻮﮔ يﺎﻫ ) ددﺮـﮔ 5 ﻦﯿـﻠﭘا .( -36 ، 36 هﺮﭘ ﯽﻠﯿﺴﮐﻮﺑﺮﮐ ﺶﺨﺑ يﺎﻬﺘﻧا ﻪﻨﯿﻣآ ﺪﯿﺳا ﻦﯿﻠﭘاوﺮـﭘ هﺪــﻧﺮﯿﮔ ﺪــﻧﺎﮕﯿﻟ ناﻮــﻨﻋ ﻪــﺑ رﺎــﺑ ﻦﯿــﻟوا و ﺖــﺳا APJ ﻦﯾﺪـﻨﭼ ﻪـﮐ ﺖـﺳا هﺪـﺷ هداد نﺎﺸﻧ ﺎﻣا ،ﺪﺷ ﯽﯾﺎﺳﺎﻨﺷ ﮏﭼﻮﮐ ﺪﯿﺘﭙﭘ ﻞﻣﺎـﺷ) ﺮـﺗ 13 ﺎـﺗ 19 زا (ﻪـﻨﯿﻣآ ﺪﯿـﺳا هﺮﭘ ﻞﯿﺴﮐﻮﺑﺮﮐ يﺎﻬﺘﻧا ندﺮـﮐ لﺎـﻌﻓ رد ﻦﯿﻠﭘاوﺮـﭘ APJ يﻮﻗ نآ ﻦﯾﺮﺗﺮﺛﺆﻣ و ﺪﻨﺘﺴﻫ ﺮﺗ تﺎـﻣﺎﺗﻮﻠﮔوﺮﯿﭘ ﻪﻧﻮﻤﻧ ،ﺎﻫ ﻦﯿﻠﭘا -13 ) ﺖﺳا 4 .( ﻢﺘـــﺴﯿﺳ APJ و يﺰـــﮐﺮﻣ ﯽﺒـــﺼﻋ ﻢﺘـــﺴﯿﺳ رد ﯽـﻣ نﺎـﯿﺑ ﻂﯿﺤﻣ رد ،ﻦﯿﻨﭽﻤﻫ ) دﻮـﺷ 6 ﻢﯿـﻈﻨﺗ رد و ( ﻪــﯾﺬﻐﺗ رﺎــﺘﻓر ،نﺪــﺑ تﺎــﻌﯾﺎﻣ و ﺰﮐﻮــﻠﮔ زﺎﺘــﺳﻮﺌﻣﻮﻫ ،يا ﻮﻠﺳ ﺮﯿﺜﮑﺗ ،قوﺮﻋ ﻞﯿﮑﺸﺗ ) دراد ﺶـﻘﻧ ﯽـﻨﻤﯾا و ﯽﻟ 7 .( ﯽﻣ نﺎﺸﻧ ﺪﻫاﻮﺷ ﻢﺘـﺴﯿﺳ ،ﻦﯿـﻠﭘا ﯽﻠﺻا فﺪﻫ ﻪﮐ ﺪﻫد ﯽﺒﻠﻗ - ﯽﻣ ﻦﯿﻠﭘا زا ،ﻦﯾا ﺮﺑ هوﻼﻋ .ﺖﺳا ﯽﻗوﺮﻋ ﻪـﺑ ناﻮﺗ .دﺮـﮐ هدﺎﻔﺘـﺳا ﯽـﺒﻠﻗ ﯽﯾﺎـﺳرﺎﻧ ﺮﮐرﺎـﻣﻮﯿﺑ ﮏـﯾ ناﻮﻨﻋ ﯽﻣ نآ ﻢﯿﻘﺘـﺴﻣ ﮏـﯾژﻮﻟﻮﯿﺑ رﺎﺛآ زا ،ﻦﯿﻨﭽﻤﻫ ﻪـﺑ ناﻮـﺗ قوﺮـﻋ ﯽﮔﺪـﻨﻨﮐ دﺎـﺸﮔ و ﺐﻠﻗ ﯽﺿﺎﺒﻘﻧا ترﺪﻗ ﺶﯾاﺰﻓا رﺎﺷا ) دﻮﻤﻧ ه 8 لﺎـﻘﺘﻧا ﺮـﺑ ﻦﯿـﻠﭘا يراﺬﮔﺮﯿﺛﺄﺗ ﺖﻠﻋ ﻪﺑ .( ﯽـﺿﺎﺒﻘﻧا ترﺪـﻗ ﺮـﺑ ﺮـﺛا ،ﻦﯿـﻨﭽﻤﻫ و ﻞـﻤﻋ ﻞﯿﺴﻧﺎﺘﭘ ﺖﯿﺳﻮﯿﻣﻮﯾدرﺎﮐ ﻦﯿـﻠﭘا ﻪﮐ ﺖﺳا نآ زا ﯽﮐﺎﺣ ﺪﻫاﻮﺷ ،ﺎﻫ ﯽــﻣ يﺰــﯿﻠﻫد نﻮﯿــﺳﻼﯾﺮﺒﯿﻓ يژﻮﻟﻮﯾﺰﯿﻓﻮﺗﺎــﭘ ﺪــﻧاﻮﺗ ) Atrial fibrillation ﺎﯾ AF ) ﺪﻨﮐ ﻞﯾﺪﻌﺗ ار ( 9 .( ﻪـﮐ ﺖـﺳا هدﺮـﮐ شراﺰـﮔ ﯽﺗﺎـﻌﻟﺎﻄﻣ ﺞﯾﺎﺘﻧ ﺢﻄـﺳ رﺎـﭼد نارﺎـﻤﯿﺑ رد ﻦﯿﻠﭘا ﯽﻣﺮﺳ AF هوﺮـﮔ ﻪـﺑ ﺖﺒـﺴﻧ ﯽــﻣ ﺶﻫﺎــﮐ ﺪﻫﺎــﺷ ) ﺪــﺑﺎﯾ 11 ، 10 ﺞﯾﺎــﺘﻧ ،ﻦﯿــﻨﭽﻤﻫ .( ﺶﻫوﮋــﭘ Falcone ﺮــﻄﺧ ﻪــﮐ داد نﺎــﺸﻧ نارﺎــﮑﻤﻫ و راﺪـﻘﻣ ﻪـﮐ ﯽﻧارﺎﻤﯿﺑ رد نﺎﻣرد زا ﺲﭘ ﯽﻤﺘﯾرآ ﺖﺸﮔﺮﺑ يداﺮﻓا ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ،دﻮﺑ ﻪﻧﺎﯿﻣ زا ﺮﺘﻤﮐ نﺎﺸﻣﺮﺳ ﻦﯿﻠﭘا ﺷاد ﯽﯾﻻﺎﺑ ﻦﯿﻠﭘا ﯽﻣﺮﺳ ﺢﻄﺳ ﻪﮐ ،ﺪﻨﺘ 1/ 3 ﺮﺘﺸﯿﺑ ﺮﺑاﺮﺑ ) دﻮﺑ 12 .( Gurger نارﺎﮑﻤﻫ و ﻖﯿﻘﺤﺗ رد ﺎـﺑ ﻪـﮐ دﻮـﺧ ﻦﯿﻠﭘآ ﯽﻣﺮﺳ ﺢﻄﺳ ﯽﺳرﺮﺑ فﺪﻫ -12 ﻼﺘﺒﻣ نارﺎﻤﯿﺑ رد ﻪﺑ PSVT ﻪـﮐ ﺪـﻨﺘﻓﺎﯾ ﺖـﺳد ﻪﺠﯿﺘﻧ ﻦﯾا ﻪﺑ ،ﺪﺷ مﺎﺠﻧا ﻦﯿــﻠﭘا ﯽﻣﺮــﺳ ﺢﻄــﺳ -12 ﻪــﺑ نﺎــﯾﻼﺘﺒﻣ رد PSVT ﻦﯿﯾﺎﭘ ﯽـﻣ ﺪﻫﺎـﺷ هوﺮﮔ زا ﺮﺗ ) ﺪـﺷﺎﺑ 13 .( ﺮـﮐذ ﻪـﺑ مزﻻ ﻪﻌﻟﺎﻄﻣ ﺞﯾﺎﺘﻧ ﻪﮐ ﺖﺳا Gurger ) نارﺎﮑﻤﻫ و 13 ( زا ﺪﻌﺑ ﺢﻄـﺳ نآ رد و هﺪـﯾدﺮﮔ ﺮـﺸﺘﻨﻣ ﺮـﺿﺎﺣ ﯽﺳرﺮﺑ عوﺮﺷ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ ﯽﻣﺮﺳ II هزاﺪﻧا .ﺖﺳا هﺪﺸﻧ يﺮﯿﮔ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ ،ﺮﮕﯾد فﺮﻃ زا II رﺎـﺸﻓ ﻢﯿﻈﻨﺗ رد ﺰﯿﻧ ﺖﺳﻼﺑوﺮﺒﯿﻓ ﺮﯿﺜﮑﺗ ،نﻮﺧ ﺶـﻘﻧ ﺐـﻠﻗ ﯽـﻓوﺮﺗﺮﭙﯿﻫ و ﺎﻫ ) دراد 14 وﮋﭘ ﺞﯾﺎﺘﻧ .( ﻢﺘـﺴﯿﺳ رﺎﻬﻣ ﻪﮐ داد نﺎﺸﻧ ﯽﺸﻫ ﻦﯿﻧر - ) ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ Renin-angiotensin system ﺎـﯾ RAS ﯽﻤﺘﯾرآ ناﺰﯿﻣ ،( ﯽﺒﻠﻗ ﻪﺘﮑﺳ زا ﺪﻌﺑ ار ﯽﻨﻄﺑ يﺎﻫ ﯽﻣ ﺶﻫﺎﮐ ) ﺪﻫد 15 ،ﻦﯿﻨﭽﻤﻫ .( ﻪﻌﻟﺎﻄﻣ ﻪـﺠﯿﺘﻧ يا يﺮﯿﮔ دﺮﮐ هﺪﻨﻨﮐ رﺎﻬﻣ ﻪﮐ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ هﺪﻨﻨﮐ ﻞﯾﺪﺒﺗ ﻢﯾﺰﻧآ يﺎﻫ ) Angiotensin-converting enzyme ﺎﯾ ACE ﺚـﻋﺎﺑ ،( زوﺮﺑ ناﺰﯿﻣ ﺶﻫﺎﮐ AF ﯽﻣ ) دﻮﺷ 16 ﯽـﻨﺒﻣ يﺪﻫاﻮﺷ .(

(3)

يژﻮـﻟﻮﯾﺰﯿﻓوﺮﺘﮑﻟا ﺮـﺑ ﻦﯿـﺴﻧﺎﺗﻮﯾﮋﻧآ ﻢﯿﻘﺘـﺴﻣ ﺮﯿﺛﺄـﺗ ﺮﺑ لﻮﻠﺳ ) دراد دﻮﺟو ﯽﺒﻠﻗ يﺎﻫ 18 -16 .( رد ﻪﺘﺒﻟا ﮓﻨﯿﻟﺎﻨﮕﯿـﺳ يﺎﻫﺮﯿـﺴﻣ ﻦﯿـﺑ ﻪـﮐ ﯽﻟﺎـﺣ لﻮﻠﺳ رد ﻦﯿﻠﭘا و ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ ﻪﺑﺎﺸﺗ ﺐﻠﻗ درﺎﮐﻮﯿﻣ يﺎﻫ ـﻃ ﻪـﺑ ﺐـﻠﻗ ﺮـﺑ نﺎـﺷدﺮﮑﻠﻤﻋ ،دراد دﻮﺟو ﺎـﺑ ﻞـﻣﺎﮐ رﻮ راﺪــﻘﻣ ،لﺎــﺜﻣ رﻮــﻃ ﻪــﺑ .ﺖــﺳا توﺎــﻔﺘﻣ ﺮﮕﯾﺪــﮑﯾ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ II ﯽﺒﻠﻗ ﯽﯾﺎﺳرﺎﻧ رد ﯽﻣ ﻻﺎﺑ ﯽﻟﺎـﺣ رد ؛دور ﯽـﻣ ﺶﻫﺎﮐ ﻦﯿﻠﭘا راﺪﻘﻣ ﻪﮐ ﻦﯿـﺴﻧﺎﺗﻮﯾﮋﻧآ ﺎـﯾ و ﺪـﺑﺎﯾ II ﯽﻣ ﻦﻄﺑ زوﺮﺒﯿﻓ و ﯽﻓوﺮﺗﺮﭙﯿﻫ ﺚﻋﺎﺑ ﻪـﮐ ﯽﻟﺎﺣ رد ؛دﻮﺷ نوﺮﺑ ﻦﯿﻠﭘا ﯽﻣ ﺶﯾاﺰﻓا ﯽﻓوﺮﺗﺮﭙﯿﻫ نوﺪﺑ ار ﺐﻠﻗ هد ﺪﻫد ) 19 ﻤﻫ .( ،ﻦﯿﻨﭽ هﺪﻧﺮﯿﮔ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ و ﻦﯿﻠﭘا ﯽﻣ ﺪﻨﻧاﻮﺗ ﻞـﺼﺘﻣ ﺮﮕﯾﺪـﮑﯾ ﻪـﺑ ﯽﮑﯿﻧﺎـﮑﻣ ﻞﮑﺷ ﻪﺑ ﺎﺸﻏ ﺢﻄﺳ رد و ﺪﻧﻮﺷ ار ﺮﻤﯾدوﺮﺘﻫ ﮏﯾ ﻞﯿﮑﺸﺗ ﺑ ﻫﺪ ﻨ ﺪ ) 20 .( ،ﻦﯾاﺮﺑﺎﻨﺑ ﯽﻣ ﺮﻈﻧ ﻪﺑ ﻪﮐ ﺪﺳر ﺶﻨﮐاو ﯽﻠﺑﺎـﻘﺘﻣ يﺎـﻫ و ﻦﯿﻠﭘا ﻦﯿﺑ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ هﺪﻧﺮﯿﮔ ﺢﻄﺳ رد ﻢﻫ ﻢـﻫ و ﺎﻫ ﻢــﺴﯿﻧﺎﮑﻣ ﺢﻄــﺳ رد راد دﻮــﺟو ﯽﻟﻮﻠــﺳ ﻞــﺧاد يﺎــﻫ .د رد ﻦﯿـﻠﭘا ﯽﻣﺮـﺳ ﺢﻄـﺳ ﻦﯿـﯿﻌﺗ ﻦﻤـﺿ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ ﻪﺑ نﺎﯾﻼﺘﺒﻣ PSVT ﻦﯿـﺴﻧﺎﺗﻮﯾﮋﻧآ ﯽﻣﺮـﺳ ﺢﻄـﺳ ، II ار داد راﺮﻗ ﯽﺳرﺮﺑ درﻮﻣ ﺰﯿﻧ . ﻪﻌﻟﺎﻄﻣ هﻮﯿﺷ ﯽﻔﯿﺻﻮﺗ عﻮﻧ زا ﺶﻫوﮋﭘ ﻦﯾا - ترﻮﺻ ﻪﺑ ﻪﮐ دﻮﺑ ﯽﻠﯿﻠﺤﺗ لﺎﺳ رد ﯽﻌﻄﻘﻣ 1395 .ﺖـﻓﺮﮔ مﺎـﺠﻧا نﺎﻣﺮﮐ ﺮﻬﺷ رد ﻪﻧﻮﻤﻧ ﺎﻫ و سﺮﺘﺳد رد شور ﻪﺑ لﻮـﻣﺮﻓ زا هدﺎﻔﺘـﺳا ﺎـﺑ ،ﻪﻧﻮﻤﻧ ﻢﺠﺣ 76 ) ﺮـﻔﻧ 38 و رﺎـﻤﯿﺑ 38 (ﻢﻟﺎـﺳ ﺪﻫﺎـﺷ ،ﻪﻌﻟﺎﻄﻣ ﻪﺑ دورو يﺎﻫرﺎﯿﻌﻣ ﯽﺳرﺮﺑ هﻮﺤﻧ .ﺪﻧﺪﺷ بﺎﺨﺘﻧا ﯽﻨﯿﻟﺎﺑ ﻢﯾﻼﻋ ﻦﺘﺷاﺪﻧ ﺮﻈﻧ زا وا ﻪﻨﯾﺎﻌﻣ و رﺎﻤﯿﺑ زا لاﺆﺳ يﺮـﻧوﺮﮐ يرﺎـﻤﯿﺑ ﻪﻘﺑﺎﺳ و نﻮﺧ رﺎﺸﻓ و ﯽﺒﻠﻗ ﯽﯾﺎﺳرﺎﻧ ـﻔﻧ ﻪـﺑ يﺪﻫاﻮـﺷ ﻪـﻨﯾﺎﻌﻣ رد ﻪـﮐ ﯽﻧارﺎﻤﯿﺑ .دﻮﺑ ﯽﺒﻠﻗ ﻊ و ﯽﻓاﺮﮔﻮﯾدرﺎـﮐﻮﮐا مﺎﺠﻧا زا ﺪﻌﺑ ،ﺪﻨﺘﺷاد ﯽﺒﻠﻗ ﯽﯾﺎﺳرﺎﻧ .ﺪﻧﺪﺷ فﺬﺣ ﻖﯿﻘﺤﺗ زا ،ﯽﺒﻠﻗ ﯽﯾﺎﺳرﺎﻧ تﺎﺒﺛا ترﻮﺻ رد ﯽﮑـﺷﺰﭘ قﻼـﺧا ﻪـﺘﯿﻤﮐ ﻂـﺳﻮﺗ حﺮـﻃ ﺐﯾﻮﺼﺗ زا ﺲﭘ ﯽــﺳرﺮﺑ زا ﺪــﻌﺑ و نﺎــﻣﺮﮐ ﯽﮑــﺷﺰﭘ مﻮــﻠﻋ هﺎﮕــﺸﻧاد ﻪﻧﻮﻤﻧ ،ﻪﻌﻟﺎﻄﻣ ﻪﺑ دورو يﺎﻫرﺎﯿﻌﻣ ﺖﮐﺮﺷ ﺶﻫوﮋﭘ رد ﺎﻫ ﻞﻣﺎــﺷ دورو يﺎــﻫرﺎﯿﻌﻣ .ﺪﻧﺪــﺷ هداد ﻪــﺑ ﻼﺘــﺑا مﺪــﻋ يرﺎـــﻤﯿﺑ ،ﯽـــﺒﻠﻗ ﻢـــﺴﯿﺗﺎﻣور ،ﺮـــﻧوﺮﮐ قوﺮـــﻋ يﺎـــﻫ يرﺎـــﻤﯿﺑ ،ﯽﺗﺎـــﭘﻮﯿﻣﻮﯾدرﺎﮐ ﻪـــﭽﯾرد يﺎـــﻫ ،ﺐـــﻠﻗ يا يﺎــــــﻫوراد فﺮــــــﺼﻣ مﺪــــــﻋ Beta-blocker و Angiotensin-converting-enzyme inhibitors ) ACEIs ﺖﯾﺎﺿر و نﻮﺧ يرﺎﺸﻓﺮﭘ و ﺪﯿﺋوﺮﯿﺗ يرﺎﮐﺮﭘ ،( ﻞـﻣﺎﮐ تﺎﺤﯿﺿﻮﺗ .دﻮﺑ ﻪﻌﻟﺎﻄﻣ رد ﺖﮐﺮﺷ ياﺮﺑ ﯽﺒﺘﮐ زا رد ﻖﯿﻘﺤﺗ ﻢﯿﺗ يﻮﺳ ﻪﻨﯿﻣز حﺮﻃ ياﺮﺟا هﻮﯿﺷ و فاﺪﻫا نآ ﻪـﺑ و ﺪﯾدﺮﮔ ﻪﯾارا نﺎﮔﺪﻨﻨﮐ ﺖﮐﺮﺷ ﻪﺑ نﺎـﻨﯿﻤﻃا ﺎـﻫ ﺖـﻬﺟ ﻂﻘﻓ نﺎﻧآ زا هﺪﺷ ﺖﻓﺎﯾرد تﺎﻋﻼﻃا ﻪﮐ ﺪﺷ هداد ﻪﺑ و ﺖﻓﺮﮔ ﺪﻫاﻮﺧ راﺮﻗ هدﺎﻔﺘﺳا درﻮﻣ ﯽﺗﺎﻘﯿﻘﺤﺗ فاﺪﻫا ﯽﻣ ﯽﻗﺎﺑ ﻖﯿﻘﺤﺗ ﻢﯿﺗ دﺰﻧ ﻪﻧﺎﻣﺮﺤﻣ ترﻮﺻ .ﺪﻧﺎﻣ زا ﻪﮐ دﻮﺑ ترﻮﺻ ﻦﯾا ﻪﺑ رﺎﮐ شور 38 ﯽﻧﺎﺴﮐ ﺮﻔﻧ لﺎﺳ دادﺮﺧ ﺎﺗ ﻦﯾدروﺮﻓ ﯽﻧﺎﻣز ﻪﻠﺻﺎﻓ رد ﻪﮐ 1395 ﻪﺑ ﺖﻠﻋ PSVT ،ﺪـﻧدﻮﺑ هدﺮﮐ ﻪﻌﺟاﺮﻣ ﺎﻔﺷ نﺎﺘﺳرﺎﻤﯿﺑ ﻪﺑ ﺖﯾﺎﺿر ﺬﺧا زا ﺲﭘ و ﺪـﺷ مﺎـﺠﻧا ﯽﻨﯿﻟﺎـﺑ ﻪـﻨﯾﺎﻌﻣ ﻪﻣﺎﻧ ﺶﺳﺮﭘ ﻣﺎﻧ ﻪ و ﮏـﯿﻓاﺮﮔﻮﻣد تﺎـﺼﺨﺸﻣ يوﺎﺣ ﻪﮐ ﯽﯾﺎﻫ ﯾﺎﻣزآ و ﯽــﮑﯿﻨﯿﻠﮐ تﺎــﻨﯾﺎﻌﻣ ﺞﯾﺎــﺘﻧ ﺰــﯿﻧ ،دﻮــﺑ ﯽﻫﺎﮕــﺸ نﻮــﺧ ﻪــﻧﻮﻤﻧ داﺮــﻓا ﻦــﯾا زا ﺲﭙــﺳ .ﺪــﯾدﺮﮔ ﻞــﯿﻤﮑﺗ ﻪﻠـﺻﺎﻓﻼﺑ و ﺪﯾدﺮﮔ اﺪﺟ نآ مﺮﺳ و ﺪﺷ ﻪﺘﻓﺮﮔ ﻪﺗاﺮﺘﯿﺳ يﺎﻣد ﺎﺑ رﺰﯾﺮﻓ رد 80 - ﯽﺘﻧﺎﺳ ﻪﺟرد داﺮﮔ ﺖـﻓﺮﮔ راﺮﻗ ﻪـﮐ ﯽﻧﺎـﻣز ﺎﺗ شور ﻪـﺑ ﻦﯿـﺴﻧﺎﺗﻮﯾﮋﻧآ و ﻦﯿـﻠﭘا راﺪـﻘﻣ

Enzyme-linked immunosorbent assay

) ELISA ( هزاﺪﻧا ﻞﻣﺎﺷ ﺰﯿﻧ ﺪﻫﺎﺷ هوﺮﮔ .دﻮﺷ يﺮﯿﮔ 38 داﺮـﻓا ﺮـﻔﻧ نارﺎـﻤﯿﺑ ﺎـﺑ ﺖﯿـﺴﻨﺟ و ﻦـﺳ ﺮـﻈﻧ زا ﻪﮐ ﺪﻧدﻮﺑ ﯽﻤﻟﺎﺳ و نﺎﺘــﺳرﺎﻤﯿﺑ نﺎــﻨﮐرﺎﮐ نﺎــﯿﻣ زا و ﺪﻨﺘــﺷاد ﺖــﻘﺑﺎﻄﻣ .ﺪﻧﺪـــﺷ بﺎـــﺨﺘﻧا ﯽﻓدﺎـــﺼﺗ رﻮـــﻃ ﻪـــﺑ نﺎﯾﻮﺠـــﺸﻧاد هداد ﮏﭼ ﮏﯾ رد هﺪﻣآ ﺖﺳد ﻪﺑ يﺎﻫ ﺪﯾدﺮﮔ ﺖﺒﺛ ﺖﺴﯿﻟ مﺮـــﻧ رد ﺲﭙـــﺳ و راﺰـــﻓا يرﺎـــﻣآ SPSS ﻪﺨـــﺴﻧ 20 )

version 20, IBM Corporation, Armonk, NY

( .ﺖﻓﺮﮔ راﺮﻗ ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ درﻮﻣ ﺪﮐ ﺎﺑ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ IR.KMU.REC.1395.89 رد ﺐﯾﻮـﺼﺗ ﻪﺑ نﺎﻣﺮﮐ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد قﻼﺧا ﻪﺘﯿﻤﮐ ﺖﺳا هﺪﯿﺳر .

(4)

ﻪﺘﻓﺎﯾ ﺎﻫ هوﺮــﮔ ﯽﻨــﺳ ﻦﯿﮕﻧﺎــﯿﻣ ﺐــﯿﺗﺮﺗ ﻪــﺑ ﺪﻫﺎــﺷ و رﺎــﻤﯿﺑ 45 / 11 ± 22 / 34 و 45 / 11 ± 06 / 34 ﺞﯾﺎﺘﻧ .دﻮﺑ لﺎﺳ نﻮﻣزآ t ﯽﻨﻌﻣ فﻼﺘﺧا ﻪﮐ داد نﺎﺸﻧ يراد هوﺮﮔ ﻦﯿﺑ ﺎـﻫ ) ﺖــﺷاﺪﻧ دﻮــﺟو ﻦــﺳ ﺮــﯿﻐﺘﻣ ﻪــﻨﯿﻣز رد 951 /0 = P .( نﻮــﻣزآ ﺞﯾﺎــﺘﻧ سﺎــﺳا ﺮــﺑ ،ﻦﯿــﻨﭽﻤﻫ 2 χ فﻼﺘــﺧا ، ﯽﻨﻌﻣ ﻦﯿﺑ يراد هﺪﻫﺎـﺸﻣ ﺖﯿـﺴﻨﺟ ظﺎـﺤﻟ زا هوﺮـﮔ ود ) ﺪﺸﻧ 599 /0 = P رد .( ﻦـﺳ ﯽﮔﺪﻨﻨﮐ شوﺪﺨﻣ ﺮﺛا ،ﻊﻗاو لﺮﺘﻨﮐ ﺖﯿﺴﻨﺟ و ﯽﮔﮋﯾو .ﺪﯾدﺮﮔ ﻌﻤﺟ يﺎـﻫ ﺖﯿ ﯽﺘﺧﺎﻨـﺷ هوﺮﮔ لوﺪﺟ رد ﺎﻫ 1 .ﺖﺳا هﺪﺷ ﻪﯾارا لوﺪﺟ 1 : نﺎﮔﺪﻨﻨﮐ ﺖﮐرﺎﺸﻣ ﮏﯿﻓاﺮﮔﻮﻣد تﺎﺼﺨﺸﻣ ﺮﯿﻐﺘﻣ ﺪﻫﺎﺷ هوﺮﮔ رﺎﻤﯿﺑ هوﺮﮔ P (لﺎﺳ) ﻦﺳ ﻦﯿﮕﻧﺎﯿﻣ 06 / 34 22 / 34 951 /0 ﺖﯿﺴﻨﺟ 65 نز ﺪﺻرد 60 نز ﺪﺻرد 599 /0 ﺮﮐﻮﻠﺑ ﻢﯿﺴﻠﮐ فﺮﺼﻣ 0 ﺪﺻرد 100 ﺪﺻرد ﺎﯾ رﺎﮕﯿﺳ فﺮﺼﻣ ﻪﺑ دﺎﯿﺘﻋا رﺪﺨﻣ داﻮﻣ 20 ﺪﺻرد 20 ﺪﺻرد رﺎﻤﯿﺑ هوﺮﮔ رد ﻦﯿﻠﭘا ﯽﻣﺮﺳ ﺢﻄﺳ 58 /2 ± 00 /7 و ﺪﻫﺎﺷ هوﺮﮔ رد 75 /2 ± 62 /7 مﺮﮔﻮﻧﺎﻧ رد ﯽﻠﯿﻣ ﺮﺘﯿﻟ ﻪـﺑ نﺎﻤﻫ .ﺪﻣآ ﺖﺳد ﻪـﻧﻮﮔ ﻦﯿﮕﻧﺎـﯿﻣ ،ﺖـﺳا ﺺﺨـﺸﻣ ﻪـﮐ ﯽﻨﻌﻣ توﺎﻔﺗ ﺎﻣا ،دﻮﺑ ﺮﺘﻤﮐ نارﺎﻤﯿﺑ هوﺮﮔ رد ﻦﯿﻠﭘا يراد ) ﺖـﺷاﺪﻧ دﻮـﺟو هوﺮﮔ ود ﻦﯿﺑ 03 /1 = t ، 302 /0 = P .( ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ ﯽﻣﺮﺳ ﺢﻄﺳ II ﻪﺑ ﺪﻫﺎﺷ و رﺎﻤﯿﺑ هوﺮﮔ رد ﺐﯿﺗﺮﺗ 46 /4 ± 86 / 31 و 03 /4 ± 94 / 34 مﺮﮔﻮﻧﺎـﻧ رد ﯽﻠﯿﻣ ﺮﺘﯿﻟ ﯽـﻨﻌﻣ توﺎـﻔﺗ ﻪـﮐ دﻮـﺑ يراد هوﺮـﮔ ود ﻦﯿـﺑ ) ﺪﺷ هﺪﻫﺎﺸﻣ 07 /3 = t ، 003 /0 = P رد ناﺰـﯿﻣ ﻦﯾا و ( .دﻮﺑ ﺮﺘﻤﮐ رﺎﻤﯿﺑ هوﺮﮔ ﺚﺤﺑ و ﻪﺠﯿﺘﻧ يﺮﯿﮔ و ﻦﯿـﻠﭘا ﯽﻣﺮـﺳ ﺢﻄـﺳ ﯽﺳرﺮﺑ فﺪﻫ ﺎﺑ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ II ﻪـﺑ ﻼﺘـﺒﻣ نارﺎـﻤﯿﺑ رد PSVT ترﻮـﺻ ﻪﺘﻓﺎﯾ .ﺖﻓﺮﮔ ﺢﻄـﺳ ﻦﯿﮕﻧﺎـﯿﻣ ﻪـﮐ دﻮـﺑ نآ زا ﯽﮐﺎﺣ ﺎﻫ توﺎـﻔﺗ ﺎـﻣا ،دﻮـﺑ ﺮـﺘﻤﮐ نارﺎـﻤﯿﺑ هوﺮـﮔ رد ﻦﯿﻠﭘا ﯽﻣﺮﺳ ﯽﻨﻌﻣ ) ﺪﯾدﺮﮕﻧ هﺪﻫﺎﺸﻣ هوﺮﮔ ود ﻦﯿﺑ يراد 302 /0 = P .( APJ ﺎﯾ ﻦﯾﺮﮐﻮﺗا ﻢﺘﺴﯿﺳ ﮏﯾ ﯽﻣ ﻦﯾﺮﮐارﺎﭘ ﺪﺷﺎﺑ ﻪﮐ ﺖـﺳا هﺪـﺷ ﻊﯾزﻮﺗ نﺪﺑ قوﺮﻋ مﺎﻤﺗ رد ﯽﻌﯿﺳو رﻮﻃ ﻪﺑ ) 21 ﯽـﺒﻠﻗ ﻢﺘﺴﯿﺳ رد و ( - دﺎـﺸﮔ ناﻮـﻨﻋ ﻪـﺑ ﯽـﻗوﺮﻋ ) قوﺮﻋ هﺪﻨﻨﮐ 22 ﮏـﯿﭘوﺮﺗﻮﻨﯾا ﺮـﺛا ﮏـﯾ ترﻮـﺻ ﻪـﺑ ،( ﯽﻣ ﻞﻤﻋ يﻮﻗ و ﺖﺒﺜﻣ ) ﺪﻨﮐ 23 .( ﻦﯿـﻠﭘا ﻪﮐ ﺖﺳا هداد نﺎﺸﻧ ﻒﻠﺘﺨﻣ تﺎﻘﯿﻘﺤﺗ ﺞﯾﺎﺘﻧ ﻋ ﻪﯾﻮﻧﺎﺛ لﻼﺘﺧا ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ رد ﭗﭼ ﻦﻄﺑ يدﺮﮑﻠﻤ )

Dysfunction secondary left ventricular

،( ﺲﯾد و ﺐﻠﻗ ﯽﻧﺎﻘﺘﺣا ﯽﯾﺎﺳرﺎﻧ ،ﯽﺒﻠﻗ ﯽﻤﮑﺴﯾا ﯽﻣﺪﯿﭙﯿﻟ ﯽﻣ ﺶﻫﺎﮐ ) ﺪـﺑﺎﯾ 25 ، 24 ،ﺎﺘـﺳار ﻦـﯾا رد .( Gurger و ﺰﯿﻧ نارﺎﮑﻤﻫ ﺪﻧﺪﯿـﺳر ﻪـﺠﯿﺘﻧ ﻦـﯾا ﻪﺑ دﻮﺧ ﺶﻫوﮋﭘ رد ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ رد ﻦﯿﻠﭘا ﯽﻣﺮﺳ ﺢﻄﺳ ﻪﮐ PSVT ﻪـﺑ ﯽﻨﻌﻣ رﻮﻃ يراد ﻦﯿﯾﺎﭘ ) دﻮﺑ ﺪﻫﺎﺷ هوﺮﮔ زا ﺮﺗ 13 ﺎﺑ ﻪﮐ ( ﻪﺘﻓﺎﯾ ﺖﺷاد ﯽﻧاﻮﺨﻤﻫ ﺮﺿﺎﺣ ﯽﺳرﺮﺑ يﺎﻫ . تﺎـــﻌﻟﺎﻄﻣ ﺞﯾﺎـــﺘﻧ Falcone ) نارﺎـــﮑﻤﻫ و 12 و ( Ellinor ) نارﺎﮑﻤﻫ و 10 ﺢﻄـﺳ ﻪـﮐ دﻮﺑ نآ زا ﯽﮐﺎﺣ ( ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ رد ﻦﯿﻠﭘا ﯽﻣﺮﺳ AF هوﺮـﮔ ﻪـﺑ ﺖﺒﺴﻧ ﯽﻣ ﺮﺘﻤﮐ ﺪﻫﺎﺷ ﺪﺷﺎﺑ . نارﺎـﻤﯿﺑ رد ﻦﯿﯾﺎـﭘ ﻦﯿـﻠﭘا ﺢﻄﺳ ـﺑ ﻼﺘﺒﻣ ﻪ AF و PSVT ﯽـﻣ ، ﺶﻫﺎـﮐ ﻪـﺑ ﺮـﺠﻨﻣ ﺪـﻧاﻮﺗ ) ﺖﯾاﺪﻫ ﺖﻋﺮﺳ Conduction velocity ،ﻪـﺠﯿﺘﻧ رد و ( هﺎــﺗﻮﮐ نﺪــﺷ ﺮﺗ كﻮــﻠﺑ ﺖﯾاﺪــﻫ ﻞﯿﻬــﺴﺗ و جﻮــﻣ لﻮــﻃ ) Conduction block ﯽﻣ هزﺎﺟا ،ﻦﯿﻨﭽﻤﻫ .ددﺮﮔ ( ﺪﻫد زا يدﺎﯾز داﺪﻌﺗ ﻪﮐ ﻢﺘﯾر يﺎﻫ زﺎﺑ ﯽﺸﺧﺮﭼ ﺎﯾ دورو دﺪﺠﻣ ) Re-entering wavelets ( ﻪﺑ يﺰﯿﻠﻫد هﺮﮔ و ﺰﯿﻠﻫد رد ﻢﻫ ترﻮﺻ ) ﺪـﺷﺎﺑ ﻪﺘـﺷاد دﻮـﺟو نﺎـﻣز 13 ( رد ﻪـﺘﺒﻟا . ﯽﻨﻌﻣ توﺎﻔﺗ ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ يراد رد ﻦﯿـﻠﭘا ﺢﻄـﺳ ﻦﯿﺑ عﻮـﺿﻮﻣ ﻦـﯾا ﻪـﮐ ﺖـﺷاﺪﻧ دﻮـﺟو ﺪﻫﺎـﺷ و رﺎﻤﯿﺑ هوﺮﮔ ﯽﻣ ﻪـﻧﻮﻤﻧ داﺪـﻌﺗ ندﻮـﺑ ﻢـﮐ زا ﯽﺷﺎﻧ ﺪﻧاﻮﺗ درﻮـﻣ يﺎـﻫ ﯽﻣ ﺮﻈﻧ ﻪﺑ .ﺪﺷﺎﺑ ﯽﺳرﺮﺑ ﺶﻫوﮋﭘ مﺎـﺠﻧا ﻪـﮐ ﺪﺳر يﺎـﻫ ﺎﺑ ﻪﺑﺎﺸﻣ ﯽﻣ ،ﺮﺘﺸﯿﺑ ﻪﻧﻮﻤﻧ ﻢﺠﺣ ﺞﯾﺎـﺘﻧ ﻪـﺑ ﺮـﺠﻨﻣ ﺪﻧاﻮﺗ ﯽﻨﻌﻣ .ددﺮﮔ يراد ﺢﻄـﺳ ﻦﯿﮕﻧﺎـﯿﻣ ،ﺮـﺿﺎﺣ ﻪـﻌﻟﺎﻄﻣ ﺞﯾﺎـﺘﻧ سﺎـﺳا ﺮﺑ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ ﯽﻣﺮﺳ II ﯽـﻨﻌﻣ رﻮـﻃ ﻪـﺑ هوﺮـﮔ رد يراد ) دﻮﺑ ﺮﺘﻤﮐ نارﺎﻤﯿﺑ 003 /0 = P ( ﺐﻠﻏا رد ﻪﮐ ﯽﻟﺎﺣ رد ؛

(5)

راﺪﻘﻣ دراﻮﻣ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ II ﯽـﺒﻠﻗ ﯽﯾﺎﺳرﺎﻧ رد ﺶﯾاﺰـﻓا ﯽﻣ ﺪﺑﺎﯾ ) 20 نﺪﺷ لﺎﻌﻓ و ( RAS ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ ﺪﯿﻟﻮﺗ ﺎﺑ II رد يدﺮـﮑﻠﻤﻋ و يرﺎﺘﺧﺎـﺳ تاﺮـﯿﯿﻐﺗ زوﺮـﺑ ﺐﺟﻮﻣ ، ﯽﺒﻠﻗ ﻢﺘﺴﯿﺳ - ﯽﻣ ﯽﻗوﺮﻋ ) دﻮﺷ 26 زا ﯽﮐﺎـﺣ ﺪﻫاﻮﺷ .( يژﻮــﻟﻮﯾﺰﯿﻓوﺮﺘﮑﻟا ﺮــﺑ ﻦﯿــﺴﻧﺎﺗﻮﯾﮋﻧآ ﻢﯿﻘﺘــﺴﻣ ﺮﯿﺛﺄــﺗ لﻮﻠﺳ ﯽﻣ ﯽﺒﻠﻗ يﺎﻫ ) ﺪﺷﺎﺑ 18 -16 ﻼﺘـﺒﻣ نارﺎﻤﯿﺑ رد .( ﻪﺑ AF هﺪـﻧﺮﯿﮔ ﺶﯾاﺰﻓا ، ـﺴﻧﺎﺗﻮﯾﮋﻧآ يﺎـﻫ ﺰـﯿﻠﻫد رد ﻦﯿ ﯽﻣ هﺪﻫﺎﺸﻣ ﭗﭼ ) دﻮﺷ 28 ، 27 ﻪـﺘﻓﺎﯾ ﻦـﯾا ﻦﯿﯿﺒﺗ رد .( ﯽﻣ .دﺮﮐ هرﺎﺷا نارﺎﻤﯿﺑ هوﺮﮔ ﻂﺳﻮﺗ وراد فﺮﺼﻣ ﻪﺑ ناﻮﺗ يﺎـﻫوراد فﺮـﺼﻣ ﻪـﮐ ﻦـﯾا ﺖـﺳا ﺺﺨـﺸﻣ ﻪـﮐ ﻪﭽﻧآ ACEIs و

Angiotensin II receptor blockers

) ARBs ،( رد ﻦﯿــﺴﻧﺎﺗﻮﯾﮋﻧآ ﺢﻄــﺳ ﺶﻫﺎــﮐ ﻪــﺑ ﺮــﺠﻨﻣ ﯽﻣ ﯽﻤﺘﯾرآ رﺎﭼد نارﺎﻤﯿﺑ ) ددﺮﮔ 29 ( ﺎﻣا ، زا ماﺪـﮐ ﭻﯿﻫ يﺎــﻫوراد ﺮــﺿﺎﺣ ﺶﻫوﮋــﭘ رد ﯽــﺳرﺮﺑ درﻮــﻣ نارﺎــﻤﯿﺑ ﯽﻤﻧ فﺮﺼﻣ ار رﻮﮐﺬﻣ ﻪـﺑ دورو يﺎﻫرﺎﯿﻌﻣ ءﺰﺟ و ﺪﻧدﺮﮐ ﺖﺳا ﺮﮐذ ﻪﺑ مزﻻ .دﻮﺑ ﺎﻫوراد ﻦﯾا فﺮﺼﻣ مﺪﻋ ،ﻖﯿﻘﺤﺗ ﺮﮐﻮـﻠﺑ ﻢﯿـﺴﻠﮐ يﺎﻫوراد ﻪﻌﻟﺎﻄﻣ درﻮﻣ نارﺎﻤﯿﺑ ﻪﻤﻫ ﻪﮐ ﯽﻣ فﺮﺼﻣ .ﺪﻧدﺮﮐ 50 ﺖـﺤﺗ ﻂـﺳﻮﺘﻣ رﻮـﻃ ﻪـﺑ ﺪﺻرد ﻪﻧازور نﺎﻣرد 80 ﯽﻠﯿﻣ و ﺪﻨﺘـﺷاد راﺮـﻗ ﻞـﯿﻣﺎﭘارو مﺮـﮔ 50 ﻪﻧازور ﺮﮕﯾد ﺪﺻرد 60 ﯽﻠﯿﻣ هدﺎﻔﺘـﺳا مزﺎﯿﺘﻠﯾد مﺮﮔ ﯽﻣ ﺪﻧدﻮﻤﻧ ﺮﮐﻮﻠﺑ ﻢﯿﺴﻠﮐ ﻪﮐ ﯽﻧارﺎﻤﯿﺑ فﺬﺣ ترﻮﺻ رد . ﯽﻣ هدﺎﻔﺘﺳا رﺎﯿـﺴﺑ ﯽـﺳرﺮﺑ درﻮﻣ نارﺎﻤﯿﺑ داﺪﻌﺗ ،ﺪﻧدﺮﮐ ﯽﻣ رﺎﻤﺷ ﻪﺑ ﺖﯾدوﺪﺤﻣ ﯽﻋﻮﻧ ﻦﯾا و دﻮﺑ ﻢﮐ دور ﻪﭼﺮﮔا . ﯽﻣ ﺖﯾدوﺪﺤﻣ ﻦﯾا يﺪـﯾﺪﺟ ﻪﯿـﺿﺮﻓ دﺎـﺠﯾا ﺚﻋﺎﺑ ﺪﻧاﻮﺗ و ﻦﯿـﻠﭘا ناﺰـﯿﻣ ﺮـﺑ ﺮﮐﻮـﻠﺑ ﻢﯿـﺴﻠﮐ تاﺮﯿﺛﺄـﺗ ﺮـﺑ ﯽﻨﺒﻣ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ II ددﺮﮔ يﺪـﻌﺑ تﺎﻌﻟﺎﻄﻣ مﺎﺠﻧا تروﺮﺿ و يﺎـﻫوراد فﺮـﺼﻣ ﻪـﮐ ﻦـﯾا ﻪـﺑ ﻪﺟﻮﺗ ﺎﺑ .ﺪﻨﮐ ﻢﻫاﺮﻓ ار ﺮــﺑ ﺮﯿﺛﺄــﺗ ﺪــﻗﺎﻓ ﺮﮐﻮــﻠﺑ ﻢﯿــﺴﻠﮐ RAS ﯽﻣ ﺪــﺷﺎﺑ ، ءﺰــﺟ ﻪـﺑ ﻪـﺟﻮﺗ ﺎﺑ .ﺪﯾدﺮﮕﻧ ظﺎﺤﻟ ﻪﻌﻟﺎﻄﻣ زا جوﺮﺧ يﺎﻫرﺎﯿﻌﻣ ﻪﺑﺎـﺸﻣ تﺎـﻌﻟﺎﻄﻣ فﻼـﺧ ﺮـﺑ ﻦﯿﻧر ﺢﻄﺳ ﺞﯾﺎﺘﻧ ﻪﮐ ﻦﯾا ) 20 ( ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ ﺶﻫﺎﮐ زا ﯽﮐﺎﺣ II نارﺎﻤﯿﺑ هوﺮﮔ رد ﯽﻣ ﺮﮐﻮﻠﺑ ﻢﯿﺴﻠﮐ يﺎﻫوراد فﺮﺼﻣ عﻮﺿﻮﻣ ،دﻮﺑ ﻪـﺑ ﺪﻧاﻮﺗ ﻪﯿﺿﺮﻓ ناﻮﻨﻋ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ ﺢﻄﺳ ﺶﻫﺎﮐ رد يا II درﻮﻣ فﺮﺼﻣ ﻪﮐ دراد دﻮﺟو لﺎﻤﺘﺣا ﻦﯾا و دﺮﯿﮔ راﺮﻗ ﻪﻌﻟﺎﻄﻣ ﺎﻤﯿﺑ رد ﺎﻫوراد ﻦﯾا ﻦﯿـﻨﭼ ﻪـﺑ ﺮـﺠﻨﻣ ﯽﺳرﺮﺑ درﻮﻣ نار ﻪﺠﯿﺘﻧ .ﺪﺷﺎﺑ هﺪﺷ يا ﻦﯿﮕﻧﺎـﯿﻣ ﻪـﮐ ﺪـﯾدﺮﮔ ﺺﺨـﺸﻣ ﺮـﺿﺎﺣ ﺶﻫوﮋﭘ رد ﻦـﯾا ﺎـﻣا ،دﻮﺑ ﺮﺘﻤﮐ نارﺎﻤﯿﺑ هوﺮﮔ رد ﻦﯿﻠﭘا ﯽﻣﺮﺳ ﺢﻄﺳ ﯽﻨﻌﻣ توﺎﻔﺗ تﺎـﻌﻟﺎﻄﻣ مﺎـﺠﻧا ،ﻪـﻨﯿﻣز ﻦـﯾا رد .دﻮـﺒﻧ راد ﻪﻧﻮﻤﻧ ﺎﺑ ﺮﺘﺸﯿﺑ هدﺮﺘـﺴﮔ ﻪـﻧﻮﻤﻧ ﻢﺠﺣ و ﺮﮕﯾد يﺎﻫ ﺮﺗ ﻪـﺑ ﯽــﻨﻌﻣ توﺎــﻔﺗ ﻪــﺑ ﻦﺘﻓﺎــﯾ ﺖــﺳد رﻮــﻈﻨﻣ دﺎﻬﻨــﺸﯿﭘ ،راد ﯽﻣ ﻪﺑﺎـﺸﻣ تﺎـﻘﯿﻘﺤﺗ فﻼـﺧ ﺮﺑ ،ﻦﯿﻨﭽﻤﻫ .ددﺮﮔ ) 20 ( ، ﯽـــﻨﻌﻣ ﺶﻫﺎـــﮐ رد يراد ﯽﻣﺮـــﺳ ﺢﻄـــﺳ ﻦﯿﮕﻧﺎـــﯿﻣ ﻦﯿــﺴﻧﺎﺗﻮﯾﮋﻧآ II ﻦــﯾا .ﺪــﺷ هﺪﻫﺎــﺸﻣ نارﺎــﻤﯿﺑ هوﺮــﮔ رد ﯽــﻣ عﻮــﺿﻮﻣ ﻢﯿــﺴﻠﮐ فﺮــﺼﻣ زا ﯽــﺷﺎﻧ ﺪــﻧاﻮﺗ ﺮﮐﻮــﻠﺑ رد ﺶﻫوﮋﭘ مﺎـﺠﻧا ﻪﮐ ﺪﺷﺎﺑ نارﺎﻤﯿﺑ يﺎـﻫ ﻪـﻧﺎﮔاﺪﺟ ﻦـﯾا رد ﯽﻣ ﻪﯿﺻﻮﺗ صﻮﺼﺧ دﻮﺷ ﯽﻣﺮـﺳ ﺢﻄـﺳ ﺶﻫﺎﮐ لﺎﻤﺘﺣا . ﻢﯿﺴﻠﮐ زا هدﺎﻔﺘﺳا ﺎﺑ ﻦﯿﺴﻧﺎﺗﻮﯾﮋﻧآ ﺎﻫﺮﮐﻮﻠﺑ ﯽﺒﻟﺎـﺟ ﻪﯿﺿﺮﻓ .دﻮـﺷ ﺪـﯿﯾﺄﺗ يﺮﺘـﺸﯿﺑ تﺎـﻌﻟﺎﻄﻣ رد ﺪﯾﺎﺑ ﻪﮐ دﻮﺑ ﺪﻫاﻮﺧ فﺮـﺼﻣ ﻂـﺳﻮﺗ ﻦﯿـﻧر ﺢﻄـﺳ ﺶﻫﺎـﮐ ﯽﺗﺎـﻘﯿﻘﺤﺗ ﺞﯾﺎﺘﻧ شﻮـﻣ رد ﺮﮐﻮﻠﺑ ﻢﯿﺴﻠﮐ ﺖـﺳا هﺪﻧﺎـﺳر تﺎـﺒﺛا ﻪـﺑ ار ﺎـﻫ ) 31 ، 30 اراد ﺮﺿﺎﺣ ﺶﻫوﮋﭘ .( ﺖﯾدوﺪﺤﻣ ي دﻮﺑ ﯽﯾﺎﻫ ﻪﮐ ﯽﻣ ﻪﻠﻤﺟ نآ زا و نارﺎـﻤﯿﺑ ﻪﺑ ﯽﺳﺮﺘﺳد ﻪﺑ ناﻮﺗ فﺮـﺼﻣ ﻪـﮐ دﺮـﮐ هرﺎـﺷا ﯽـﺳرﺮﺑ درﻮـﻣ نارﺎﻤﯿﺑ هوﺮﮔ رد ﺎﻫوراد ﯽﻣ ﺪﻨﮐ دﺎﺠﯾا لﻼﺘﺧا هﺪﻣآ ﺖﺳد ﻪﺑ ﺞﯾﺎﺘﻧ رد ﺪﻧاﻮﺗ . ﯽﻧادرﺪﻗ و ﺮﮑﺸﺗ ﻦﯾﺪــﺑ ﻪﻠﯿــﺳو زا ﺖــﻧوﺎﻌﻣ ــﺸﻫوﮋﭘ ﯽ ﺰــﮐﺮﻣ ﻘﺤﺗ ﯿ تﺎــﻘ ﻓﯿ ﺰﯾ ژﻮﻟﻮ ي و نارﺎﯿﺘﺳد ﺑ قوﺮـﻋ و ﺐﻠﻗ ﯿ نﺎﺘـﺳرﺎﻤ ﺎﻔـﺷ ﯽﻣ ﻞﻤﻋ ﻪﺑ ﯽﻧادرﺪﻗ و ﺮﮑﺸﺗ ﯾآ ﺪ . ﻨﭽﻤﻫ ﯿ ﻦ ، تﺎـﻤﺣز زا رﺎﮐﺮﺳ ﺟﻮﻨﻬﮐ ﺮﺘﮐد ﻢﻧﺎﺧ ﯽ ﻪﮐ رد مﺎﺠﻧا ا ـﯾ ﻦ ﺶﻫوﮋـﭘ ﯽﻣ يراﺰﮕﺳﺎﭙﺳ ،ﺪﻧدﻮﻤﻧ يرﺎﮑﻤﻫ ددﺮﮔ . References

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1- Assistant Professor, Department of Cardiology AND Physiology Research Center, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

2- Resident, Department of Cardiology AND Physiology Research Center, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

3- PhD Candidate, Department of Epidemiology AND Physiology Research Center, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

The Relationship between Apelin and Angiotensin II in Paroxysmal Supraventricular Tachycardia

Masoomeh Kahnooji1, Fatemeh Rahmani2*, Ahmad Naghibzadeh3,

Mahboobeh Yeganeh4, Yaser Masoomi4

Received: 21 Nov. 2016 Accepted: 02 Feb. 2017 Published: 04 Apr. 2017

Abstract

Background: We aimed to investigate apelin and angiotensin II serum levels in patient whit paroxysmal supraventricular tachycardia.

Methods: This was a cross-sectional study on 38 patients with paroxysmal supraventricular tachycardia (PSVT), and 38 age- and sex-matched healthy individuals. Blood samples were taken from these people, and angiotensin II/apelin levels were measured using enzyme-linked immunosorbent assay (ELISA). To analyze the data, descriptive statistics were used. Results: Apelin levels were lower in PSVT group compared to control group; but the difference was not significant (P = 0.302). Angiotensin II levels were significantly lower in PSVT groups compared to controls (P = 0.003).

Conclusion: Like similar studies, this study showed that apelin serum levels were lower in PSVT groups, but this difference was not significant. However, mean serum levels of angiotensin II was significantly lower in PSVT groups. This could be due to the consumption of calcium blockers in these patients.

Keywords: Apelin, Angiotensin II, Supraventricular tachycardia

Citation: Kahnooji M, Rahmani F, Naghibzadeh A, Yegane M, Masoomi Y. The Relationship

between Apelin and Angiotensin II in Paroxysmal Supraventricular Tachycardia. Afzalipour J

Clin Res 2017; 2(1-2): 38-45.

References

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