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Edaravone-Encapsulated Agonistic Micelles Rescue Ischemic Brain Tissue by Tuning Blood-Brain Barrier Permeability

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Figure

Figure 1. Agonistic micelles salvage brain ischemic tissue. EDV-AM specifically activated A2AR over-expressed in the capillaries of brain ischemia, increased BBB permeability by temporarily opening para-endothelial TJs, entered brain ischemia by crossing t
Figure 2. Synthesis and characterization of agonistic micelles. (A) Doubly immunostained microscopic fluorescence images in brain ipsilateral and contralateral striatum Synthesis of the PEG-PLA copolymer components, 100 at 24 h post-stroke attack
Figure 3. Agonistic micelles tune endothelial monolayer permeability and eradicate OGD-induced intracellular ROS
Figure 4. Agonistic micelles increase EDV uptake in brain ischemia. (A) NIR fluorescence images of the mouse brain at 24 h PI of EDV-AM or EDV-PM (0.078 mg EDV-AMin the excised brain ischemia at 24 h PI of EDV-AM or EDV-PM (n = 5)
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