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In vivo continuous evolution of metabolic pathways for chemical production

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Figure

Fig. 1 Illustration of in vivo continuous evolution. a General concept of in vivo continuous evolution as an uninterrupted Darwinian evolution occurs for an extended period of time in continuous culturing system
Table 1 In vivo genotype diversification strategies for in vivo continuous evolution
Fig. 2 In vivo genotype diversification. a Modified natural mutagenesis system. Random mutagenesis with higher mutation rate is induced with mutators
Table 2 Fitness‑coupled selection pressure for in vivo continuous evolution
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