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Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation

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Figure

Figure 1. CaMK4 promotes glycolysis under ionomycin stimulation. (analyzed by an extracellular flux analyzer
Table 1. Candidate proteins binding to CaMK4 protein identified by mass spectrometry
Figure 2. CaMK4 binds to PKM2 and increases pyruvate kinase activity. (transfected with Flag-mCaMK4 under Th17-polarizing conditions, followed by coimmunoprecipitation using Flag or mouse IgG Abs
Figure 3. PKM2 promotes in vitro Th1 and Th17 differentiation. (under Th1- and Th17-polarizing conditions and various concentration of shikonin were added on day 0
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