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The Effect of Temperature, pH and the Glucose Concentration on Germ The Effect of Temperature, pH and the Glucose Concentration on Germ

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(1)

،ﺎﻣدﺶﻘﻧ

pH

ﯽﻨﺗنوﺮﺑﻂﯾاﺮﺷردﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗناﺰﯿﻣﺮﺑﺰﮐﻮﻠﮔﺖﻈﻠﻏناﺰﯿﻣو

) In vitro (

ﺲﻨﮑﯿﺒﻟآاﺪﯾﺪﻧﺎﮐچرﺎﻗﻂﺳﻮﺗ

هﺪﯿﮑﭼ

فﺪﻫوﻪﻨﯿﻣز

:

ﻦﯾﺮـﺘﻤﻬﻣزانﺎﺴـﻧامﺮـﺳﺎﺑتروﺎﺠﻣردﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗیاﺮﺑﺲﻨﮑﯿﺒﻟآاﺪﯾﺪﻧﺎﮐﯽﯾﺎﻧاﻮﺗ

ﻐﺗیاﺮﺑﯽﻋوﺮﺷوﺖﺳاﺰﯾرﺎﻤﯿﺑیﺎﻬﻤﺴﯿﻧﺎﮑﻣ بﻮﺴـﺤﻣیاﻪﺘـﺷرﻞﮑـﺷﻪﺑیﺮﻤﺨﻣﻞﮑﺷزاچرﺎﻗﻦﯾاﺖﻟﺎﺣﺮﯿﯿ

ﺪﺷﺎﺑﯽﻣﯽﻄﯿﺤﻣﻞﻣاﻮﻋﯽﻀﻌﺑﺮﯿﺛﺎﺗﺖﺤﺗﻪﮐدﻮﺷﯽﻣ .

ﯽـﻄﯿﺤﻣﻞﻣاﻮﻋﯽﻀﻌﺑﺮﯿﺛﺎﺗﯽﺳرﺮﺑﻪﻌﻟﺎﻄﻣﻦﯾازافﺪﻫ

،ﺎﻣدﺪﻨﻧﺎﻣ

pH

ﯽﻨﺗنوﺮﺑﻂﯾاﺮﺷردﺲﻨﮑﯿﺒﻟآاﺪﯾﺪﻧﺎﮐﻪﻧﻮﮔﻂﺳﻮﺗﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗناﺰﯿﻣﺮﺑﺰﮐﻮﻠﮔﺖﻈﻠﻏناﺰﯿﻣو

ﺖﺳاهدﻮﺑ .

شور ﯽﺳرﺮﺑ

:

ﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗﺖﺴﺗ )

Germ tube

( ﺲﻨـﮑﯿﺒﻟآاﺪـﯾﺪﻧﺎﮐدراﺪﻧﺎﺘـﺳاشﻮﺳﺎﺑ )

ATCC

10231

( ،تراﺮﺣردلﺎﻣﺮﻧﺪﻨﻗیارادنﺎﺴﻧامﺮﺳزاهدﺎﻔﺘﺳاﺎﺑ

pH

هﺎﮕﺸـﯾﺎﻣزآردﺰﮐﻮﻠﮔﻒﻠﺘﺨﻣیﺎﻬﺘﻈﻠﻏو،

ﻮﻠﺳﺪﺻردﻦﯿﮕﻧﺎﯿﻣﻦﯿﻨﭽﻤﻫوﺎﯾازﻪﻟﻮﻟهﺪﻨﻨﮐﺪﯿﻟﻮﺗیﺎﻬﻟﻮﻠﺳﻦﯿﻟواﺪﯿﻟﻮﺗعوﺮﺷوﺖﻓﺎﯾمﺎﺠﻧا ﮥـﻟﻮﻟﺪـﺟاویﺎﻬﻟ

ﺪﯾدﺮﮔﻪﺒﺳﺎﺤﻣﺖﻋﺎﺳودزاﺲﭘﺎﯾاز .

ﯽﺗرﺎـﺒﻋﻪـﺑﺎﯾﻒﻠﺘﺨﻣﻂﯾاﺮﺷردﺎﯾازﻪﻟﻮﻟﺪﺟاویﺎﻬﻟﻮﻠﺳﺪﺻردﻦﯿﮕﻧﺎﯿﻣ

یرﺎـﻣآﺮـﻈﻧزایاﻪﺘـﺷرﻪـﺑیﺮـﻤﺨﻣﺖـﻟﺎﺣزاﻞﯾﺪـﺒﺗیاﺮـﺑچرﺎﻗﮏﯾﺮﺤﺗناﺰﯿﻣ

One-way ANOVA)

(

ﺪﻧﺪﺷﻪﺴﯾﺎﻘﻣ .

ﺎﻫﻪﺘﻓﺎﯾ

:

تراﺮﺣردﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗ 37

،ﻪـﺟرد

pH

اﺮﺑ ﺮـﺑ 5 / 6 ﺖـﻈﻠﻏردو

mg/ml

30 یارادﺰﮐﻮـﻠﮔ

دﻮﺑیاﻪﯾﺬﻐﺗوﯽﻄﯿﺤﻣﻂﯾاﺮﺷﺮﯾﺎﺳﺎﺑﻪﺴﯾﺎﻘﻣردناﺰﯿﻣﻦﯾﺮﺗﻻﺎﺑ )

0001 / 0

P=

.( ﻪـﺑﺮـﺠﻨﻣﻂﯾاﺮـﺷﻦﯾاﻦﯿﻨﭽﻤﻫ

دﻮﺑهﺪﺷﯽﻨﺗنوﺮﺑﻂﯾاﺮﺷردﺎﯾازﻪﻟﻮﻟﺪﺟاواﺪﯾﺪﻧﺎﮐیﺮﻤﺨﻣیﺎﻬﻟﻮﻠﺳﻦﯿﻟواهﺪﻫﺎﺸﻣیاﺮﺑنﺎﻣزﻦﯾﺮﺘﻫﺎﺗﻮﮐ .

یﺮﯿﮔﻪﺠﯿﺘﻧ :

ﺳرﯽﻣﺮﻈﻧﻪﺑ ﻪـﻟﻮﻟﺪـﯿﻟﻮﺗﻪـﺑچرﺎـﻗﮏﯾﺮﺤﺗﺚﻋﺎﺑﻂﯾاﺮﺷﻦﯿﻤﻫﻢﻫنﺎﺑﺰﯿﻣنﺪﺑردﻪﮐﺪ

ﯽـﻨﺗنوﺮـﺑﻂﯾاﺮـﺷﻪﺑﺎﺸﻣچرﺎﻗﯽﻤﺟﺎﻬﺗترﺪﻗﺪﯾﺪﺸﺗﺚﻋﺎﺑﻪﺠﯿﺘﻧردوﯽﺘﺑﺎﯾدداﺮﻓاردصﻮﺼﺨﺑ،نﺪﺑردﺎﯾاز دﻮﺷ .

یﺪﯿﻠﮐیﺎﻫهژاو

:

،ﺲﻨﮑﯿﺒﻟآاﺪﯾﺪﻧﺎﮐ ،ﺎﯾازﻪﻟﻮﻟ

،ﺎﻣد،ﯽﻨﺗنوﺮﺑ

pH

ﺰﮐﻮﻠﮔ،

ﻦﺷوﺪﻧیﺮﻔﻌﺟﯽﻠﻌﺳﺎﺒﻋ

،ﯽﺳﺎﻨﺷچرﺎﻗوﯽﺳﺎﻨﺷﻞﮕﻧاهوﺮﮔ،رﺎﯾدﺎﺘﺳا ﺪﯿﻬﺷﯽﻧﺎﻣردﯽﺘﺷاﺪﻬﺑتﺎﻣﺪﺧوﯽﮑﺷﺰﭘهﺪﮑﺸﻧاد

دﺰﯾﯽﻗوﺪﺻ

لﻮﺌﺴﻣهﺪﻨﺴﯾﻮﻧ :

ﻧیﺮﻔﻌﺟﯽﻠﻌﺳﺎﺒﻋ ﻦﺷوﺪ

ﻦﻔﻠ : 8241751 0351

ﮏﯿﻧوﺮﺘﮑﻟاﺖﺴﭘ :

jafariabbas@ssu.ac.ir

سردآ : هﺪﮑﺸــﻧاد،ﯽﻠﻋﻮﺑنﺎــﺑﺎﯿﺧ،ﻪﯿﯾﺎﻔــﺻ،دﺰــﯾ

ﯽﺳﺎﻨﺷچرﺎﻗوﯽﺳﺎﻨﺷﻞﮕﻧاهوﺮﮔ،ﯽﮑﺷﺰﭘ

ﻪﻟﺎﻘﻣلﻮﺻو :

20 / 1 / 87

ﯽﯾﺎﻬﻧحﻼﺻا :

12 / 3 / 87

ﻪﻟﺎﻘﻣشﺮﯾﺬﭘ :

27 / 3 / 87

(2)

دﻮﺷﯽﻣ .

ﯿﺗمﺮﺟﺲﮑﻋﺮﺑ ﺎﻬﯾﺪﯿﻧﻮﮐﻮﺘﺳﻼﺑﯽﻟﻮﻠﺳجرﺎﺧﺪﺷربﻮ

هراﻮـﯾدﻞﯿﮑﺸﺗنآلﺎﺒﻧدﻪﺑولﻮﻠﺳﮏﯾﯽﺳارﺪﺷرﻪﻠﯿﺳوﻪﺑﻪﮐﺖﺳ

ﺪـﯾآﯽﻣدﻮﺟوﻪﺑنآهﺪﻨﯾورکﻮﻧﺖﺸﭘردﯽﺿﺮﻋ .

ﻪـﻟﻮﻟﺖـﻘﯿﻘﺣرد

هراﻮـﯾدیارادﻪـﮐﺖـﺳاﯽﻘﯿﻘﺣمﻮﯿﻠﺴﯿﻣﻞﯿﮑﺸﺗعوﺮﺷوﻪﻣﺪﻘﻣﺎﯾاز

ﺪـﺷﺎﺑﯽـﻣیزاﻮـﻣیﺎـﻫ )

9 و 10 و 11 و 12 و 13 .( ﻂﯾاﺮـﺷرد

In vivo

ﻐﺗ ﻪﻠﯿـﺳوﻪﺑبﻮﯿﺗمﺮﺟﻪﻠﻤﺟزاولﺎﯿﻠﺴﯿﻣﻪﺑیﺮﻤﺨﻣﮏﯾژﻮﻟﻮﻓرﻮﻣﺮﯿﯿ

یاﻪــﯾﺬﻐﺗﺎﯾوﯽــﻄﯿﺤﻣﻂﯾاﺮــﺷ )

،تراﺮﺣﺪــﻨﻧﺎﻣ

pH

ﻦﺑﺮــﮐﻊــﺒﻨﻣو (

دﻮﺷﯽﻣﺖﯾﻮﻘﺗ )

1 و 2 و 14 .(

،ﺎــﻣدﺪــﻨﻧﺎﻣﯽــﻄﯿﺤﻣﻞــﻣاﻮﻋﯽﻀــﻌﺑﺮﯿﺛﺎﺗﺮــﺿﺎﺣﻪــﻌﻟﺎﻄﻣرد

pH

بﻮﯿﺗمﺮﺟﺪﯿﻟﻮﺗناﺰﯿﻣﺮﺑﺰﮐﻮﻠﮔﺖﻈﻠﻏناﺰﯿﻣو )

ﺎـﯾازﻪـﻟﻮﻟ ( ﻂـﺳﻮﺗ

اﺪﯾﺪﻧﺎﮐﻪﻧﻮﮔ ﯽﻨﺗنوﺮﺑﻂﯾاﺮﺷردﺲﻨﮑﯿﺒﻟآ

)

In vitro

( هﺪـﺷﯽـﺳرﺮﺑ

ﺖﺳا .

ﯽﺳرﺮﺑشور

سﺎـﺳاﺮـﺑﻪﮐهدﻮﺑیاﻪﻠﺧاﺪﻣﯽﻫﺎﮕﺸﯾﺎﻣزآعﻮﻧزاﻪﻌﻟﺎﻄﻣﻦﯾا

ﺎـــﯾازﻪـــﻟﻮﻟﺪـــﯿﻟﻮﺗدراﺪﻧﺎﺘـــﺳاﺖﺴـــﺗ )

Germ tube test

( رد

ﯽﻫﺎﮕﺸﯾﺎﻣزĤﻄﯾاﺮﺷ )

In vitro

( یاﺮﺑﺖﻘﯿﻘﺣردوﺖﺳاهﺪﯾدﺮﮔاﺮﺟا

زاﺲﻨﮑﯿﺒﻟآاﺪــﯾﺪﻧﺎﮐﯽــﻗاﺮﺘﻓاﺺﯿﺨﺸـﺗ رداﺪــﯾﺪﻧﺎﮐیﺎــﻫﻪﻧﻮﮔﺮﯾﺎـﺳ

تراﺮﺣ،نﺎﺴﻧامﺮﺳﺎﺑتروﺎﺠﻣ 37

ﺑ ﻪﺟرد ﻪ

ﯽـﻣرﺎـﮐ دور ) 7 .( ﻦـﯾا

،ﺎـﻣدﯽﻄﯿﺤﻣﻞﻣاﻮﻋﺶﻘﻧﯽﺳرﺮﺑیاﺮﺑﺖﺴﺗ

pH

ﺖـﯿﻤﻫاﻦﯿـﻨﭽﻤﻫو

لﺮـﺘﻨﮐﻂﯾاﺮـﺷردﺎـﯾازﻪـﻟﻮﻟﺪـﯿﻟﻮﺗﮏﯾﺮﺤﺗناﺰﯿﻣﺮﺑﺰﮐﻮﻠﮔﺖﻈﻠﻏ

ردوهﺪﺷ 5

ﺖـﻓﺎﯾمﺎﺠﻧاراﺮﮑﺗ .

دراﺪﻧﺎﺘـﺳاشﻮـﺳرﻮـﻈﻨﻣﻦـﯾایاﺮـﺑ

ﺪـــــــﯾﺪﻧﺎﮐ ﺲﻨﮑﯿﺒﻟآا

(ATCC 10231)

ﻂﯿـــــــﺤﻣیورﺮـــــــﺑ

رﺎﮔآزوﺮﺘﺴــﮐدورﻮﺑﺎﺳ )

Merck, Germany

( ﺲﭙــﺳوﻪــﯿﻬﺗﺖﺸــﮐ

یﺎـﻫﻪـﻟﻮﻟﻞـﺧادﻞﯾﺮﺘـﺳاپﻮـﻟﮏـﯾزاهدﺎﻔﺘـﺳاﺎﺑنآهزﺎﺗیﺎﻬﯿﻨﻠﮐ

یﻮﺘﺤﻣﺶﯾﺎﻣزآ 5

/ 0 نﺎﺴﻧامﺮﺳﺮﺘﯿﻟﯽﻠﯿﻣ )

ـﻗﺎﺑیدﺮﻓمﺮﺳ ـ

نﻮـﺧﺪﻨ

ﻧـ ﻣﺮ ـ ﻣلﺎ ـ ﻌ ـ ﻣلدﺎ ـ ﮔناﺰﯿ ـﻠ ـ ﺰﮐﻮ 90

mg/dl

ﻧ ـ ﺷﺎ ـ ﺎﺘ ( ﺳ ـ ﺳﻮ ــ ﭙـ ﺴـﻧﺎ ــ نﻮﯿ

CFU/ml)

105 × 1 (

ﺪﯾدﺮﮔﻪﯿﻬﺗ .

رﻮﮐﺬـﻣﻞـﻣاﻮﻋﺶـﻘﻧﯽﺳرﺮﺑیاﺮﺑ

نﻮﯿﺴﻧﺎﭙﺳﻮﺳﻦﯾا ﻂﯾاﺮﺷرد

ﺘﺨﻣ ـ ﻨﮐﻒﻠ ـ لﺮﺘ تﺪﻣﻪﺑهﺪﺷ 2

ﺳ ـ ﻋﺎ ـ ﺖ

ﻧ یراﺪــــﻬﮕ ﺪﻧﺪــــﺷﺶﯾﺎــــﻣزآو

. ﻂﯾاﺮــــﺷﻦــــﯾا ﻪــــﺟردﻞﻣﺎــــﺷ

یﺎﻬﺗراﺮﺣ 27

، 32 ، 37 و 42 ﻪﺟرد ،داﺮﮕﯿﺘﻧﺎـﺳ

pH

ﺮـﺑاﺮﺑیﺎـﻫ 5

/ 5 , 6 ،

5 / 6 ، 7

ﺮﻔـﺻیﺎـﻬﺘﻈﻠﻏﺎﺑتروﺎﺠﻣردو ,

10 , 20 و

mg/ml

30 ﺰﮐﻮـﻠﮔ

ﺺﻟﺎــﺧ )

Merck, Germany

( هدﻮــﺑ ﺖــﺳا . ﻢﯿــﻈﻨﺗیاﺮــﺑ

pH

ﺪﯿــﺳازا

ﮏﯾرﺪﯾﺮﻠﮐ 1

/ 0 ﺎﺑولﺎﻣﺮﻧ ﮏﻤﮐ

ﺖﭙﯿﭘوﺮﮑﯿﻣ ﺪﺷهدﺎﻔﺘﺳا

. دراﻮﻣرد

ﻪﻣﺪﻘﻣ

ﯽﭘاﺮﺗﻮـﯾدارﺪﻨﻧﺎﻣﯽﮑﺷﺰﭘیژﻮﻟﻮﻨﮑﺗﺪﯾﺪﺟیﺎﻬﺘﻓﺮﺸﯿﭘ ,

ﯽﭘاﺮﺗﻮـﻤﮐ ,

سﺮﭘﺎﺳﻮﻨﻤﯾانارﺎﻤﯿﺑﺖﯿﻌﻤﺟوﺎﻘﺑناﺰﯿﻣﺶﯾاﺰﻓاﻦﯿﻨﭽﻤﻫوﺎﻀﻋاﺪﻧﻮﯿﭘ ,

یﺎـﻬﯾرﺎﻤﯿﺑعﻮﯿـﺷوشﺮﺘﺴـﮔﻪﺑﺮﺠﻨﻣﺎﻬﯾزﺪﯾاوﺎﻬﯿﻤﯿﺧﺪﺑﻪﺑﻼﺘﺒﻣداﺮﻓا

ﺖـﺳاهﺪـﺷﻪﺘـﺷﺬﮔﻪـﻫدﺪﻨﭼلﻮـﻃردﺐـﻠﻃﺖـﺻﺮﻓﯽﭼرﺎﻗ )

1 و 2 .(

ﻢـﯾﻼﻋیارادوﺐﻠﻃﺖﺻﺮﻓﯽﭼرﺎﻗیﺎﻬﯾرﺎﻤﯿﺑﻪﻠﻤﺟزاﺲﯾزﺎﯾﺪﯾﺪﻧﺎﮐ

طﺎﺨﻣﺎﺗﻪﺘﻓﺮﮔﻦﺧﺎﻧوﺖﺳﻮﭘزاﺪﻧاﻮﺗﯽﻣﻪﮐﺖﺳاعﻮﻨﺘﻣرﺎﯿﺴﺑﯽﻨﯿﻟﺎﺑ

ﻧﺎﮔراونژاو،نﺎﻫد ﯽﻠﺧادیﺎﻬ

) ﮏﯿﻤﺘﺴﯿﺳﺲﯾزﺎﯾﺪﯾﺪﻧﺎﮐ (

ﺮـﯿﮔردار

ﺪﯾﺎﻤﻧ . ﻦﯿﻣرﺎـﻬﭼ،اﺪـﯾﺪﻧﺎﮐﻒـﻠﺘﺨﻣیﺎﻫﻪﻧﻮﮔﯽﻨﻌﯾیرﺎﻤﯿﺑﻦﯾاﻞﻣﺎﻋ

ﺖــﺳاﯽﻧﺎﺘــﺳرﺎﻤﯿﺑیاﺰﺘﻧﻮــﻔﻋﻞــﻣاﻮﻋزاﻊﯾﺎــﺷﻞــﻣﺎﻋ )

3 .( یﺎــﻫﻪــﻧﻮﮔ

لﺎــﻣﺮﻧرﻮﻠﻓزاﯽﺸــﺨﺑﺲﻨــﮑﯿﺒﻟآاﺪــﯾﺪﻧﺎﮐﻪــﻠﻤﺟزااﺪــﯾﺪﻧﺎﮐﻒــﻠﺘﺨﻣ

ﯽﻃﺎـﺨﻣویﺪـﻠﺟحﻮﻄـﺳردﻪـﮐﺖـﺳانﺎﺴـﻧانﺪﺑﯽﺑوﺮﮑﯿﻣ ،ﺖـﺳﻮﭘ،

ولﺎــﻣﺮﻧرﻮــﻠﻓترﻮــﺻﻪــﺑنﺎﺴــﻧانژاووشراﻮــﮔهﺎﮕﺘــﺳد،نﺎــﻫد

دراددﻮﺟوﺖﺴﯾﺰﻤﻫ . .

ﻪـﻠﻤﺟزااﺪـﯾﺪﻧﺎﮐﻒـﻠﺘﺨﻣیﺎﻫﻪﻧﻮﮔهوﻼﻋﻪﺑ

ﻒﯿﻌـﺿنﺪـﺑﯽـﻨﻤﯾاﻢﺘﺴﯿﺳﻪﮐﯽﻧﺎﻣزﯽﻌﯿﺒﻃرﻮﻃﻪﺑﺲﻨﮑﯿﺒﻟآاﺪﯾﺪﻧﺎﮐ

ﺖـﻟﺎﺣﺮﯿﯿﻐﺗ،درﻮﺧﯽﻣﻢﻫﻪﺑنﺪﺑلﺎﻣﺮﻧرﻮﻠﻓﯽﺑوﺮﮑﯿﻣلدﺎﻌﺗﺎﯾودﻮﺷ

ﻪﺑﻞﯾﺪﺒﺗ،هداد

دﻮـﺷﯽـﻣﻢﺟﺎـﻬﻣواﺰﯾرﺎـﻤﯿﺑﺐﻠﻃﺖﺻﺮﻓمﺮﻓ .

هوﻼـﻌﺑ

،ﺎﻬﯿﻤﯿﺧﺪﺑ،ﺎﻬﯿﺘﺑﺎﯾدردﯽﭼرﺎﻗﻢﺟﺎﻬﻣیاﺰﯾرﺎﻤﯿﺑﻞﻣاﻮﻋزاﯽﮑﯾاﺪﯾﺪﻧﺎﮐ

ﺪﺷﺎﺑﯽﻣزﺪﯾاﻪﺑﻼﺘﺒﻣداﺮﻓاوسرﺎﻧنادازﻮﻧ )

4 و 5 و 6 و 7 .(

ﻪﻧﻮﮔ ﯽﻤﺟﺎـﻬﺗﻪـﻧﻮﮔﻦﯾﺮـﺘﻤﻬﻣﺲﻨﮑﯿﺒﻟآاﺪـﯾﺪﻧﺎﮐ )

ﺖـﻧﻻوﺮﯾو (

ـــﯾوﻞـــﻣاﻮﻋزایداﺪـــﻌﺗوﺖـــﺳاﺲﯾزﺎﯾﺪـــﯾﺪﻧﺎﮐیرﺎـــﻤﯿﺑ ﺲﻧﻻوﺮ

هﺪـﺷتﺎـﺒﺛاﺰﯿﻧﯽـﺑﺮﺠﺗترﻮـﺻﻪـﺑﻪـﮐدراددﻮﺟوﺲﻨﮑﯿﺒﻟآاﺪﯾﺪﻧﺎﮐرد

ﺖﺳا ) 8 و 9 .( اﺪـﯾﺪﻧﺎﮐیژﻮـﻟﻮﻓرﻮﻣﺮـﯿﯿﻐﺗﯽﯾﺎـﻧاﻮﺗﻞـﻣاﻮﻋﻦﯾانﺎﯿﻣرد

ﺎﯾﺪﯿﻧﻮﮐﻮﺘـﺳﻼﺑﺖﻟﺎﺣزاﺲﻨﮑﯿﺒﻟآ )

یﺮـﻤﺨﻣمﺮـﻓ (

ﺎـﺑلﺎﯿﻠﺴـﯿﻣمﺮـﻓﻪـﺑ

تﺎـﻘﯿﻘﺤﺗزایرﺎﯿﺴـﺑعﻮـﺿﻮﻣچرﺎـﻗﻦـﯾاﻂـﺳﻮﺗﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗعوﺮﺷ

ﺖﺳهدﺮﺘﺴﮔ )

7 .( زا ﺲﻨـﮑﯿﺒﻟآاﺪـﯾﺪﻧﺎﮐﻪـﻧﻮﮔودﺎـﻬﻨﺗاﺪـﯾﺪﻧﺎﮐﺲﻨـﺟ

ﯽﯾﺎـﻧاﻮﺗبذﺎـﮐمﻮﯿﻠﺴـﯿﻣﺪـﯿﻟﻮﺗﯽﯾﺎـﻧاﻮﺗﺮﺑهوﻼﻋﺲﯿﺴﻨﯿﻠﺑاداﺪﯾﺪﻧﺎﮐو

ﻢـﻬﻣﺎﻬﭼرﺎﻗﻦﯾاﯽﯾاﺰﯾرﺎﻤﯿﺑردﻪﮐﺪﻧرادﺰﯿﻧبﻮﯿﺗمﺮﺟﺎﯾﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗ

ﺷزاﯽـــﻟواﻪـــﮐﺖـــﺳا ـ

ﯾﺎ ـ ـــﺘﻌ ـ ﻣوﻦﯾﺮ ـ ـــﻤﻬ ـ ﻋﻦﯾﺮﺘ ـ ـــﻣﺎ ـ ﻞ اﺪـــﯾﺪﻧﺎﮐ

زاﯽﻣودوﺲﯾزﺎﯾﺪﯾﺪﻧﺎﮐ یﺎﻫﻪﻧﻮﮔ

ﻪﺑﻼﺘﺒﻣنارﺎﻤﯿﺑنﺎﻫدزاهﺪﺷاﺪﺟ

ﺖﺳاهﺪﺷﻪﺘﺧﺎﻨﺷاﺮﯿﺧاﻪﮐﺖﺳازﺪﯾا )

7 .(

ندزﻪﻧاﻮﺟﻞﻤﻋﺎﺑیﺪﯿﻧﻮﮐﻮﺘﺳﻼﺑﻪﺑﺎﺸﻣبذﺎﮐمﻮﯿﻠﯿﺴﯿﻣ ﻞﯿﮑﺸﺗ

ﺷﯽﻣ ـ ،دﻮ ﻨﭼﺮﻫ ـ ﺼﺘﻣﺪﯾﺪﺟلﻮﻠﺳﻪﮐﺪ ـ

ﻞ ﻣلﻮﻠﺳﻪﺑ ـ ﺑردﺎ ـ دﻮ ،ه ﯾﻮﻃ ـ ﻞ

34

(3)

مود هرود ،ﯽﻫﺎﮕﺸﯾﺎﻣزآ مﻮﻠﻋ ﻪﻠﺠﻣ )

هرﺎﻤﺷ 1 ( نﺎﺘﺴﺑﺎﺗو رﺎﻬﺑ 1387

راﺪﻘﻣو 05 / 0

P≤

زا ﺪﺷﻪﺘﻓﺮﮔﺮﻈﻧردرادﯽﻨﻌﻣیرﺎﻣآﺮﻈﻧ .

ﺎﻫﻪﺘﻓﺎﯾ

ﻟﻮﺗ تراﺮﺣردﺎﯾازﻪﻟﻮﻟﺪﯿ 37

داﺮﮕﯿﺘﻧﺎﺳﻪﺟرد ,

pH

ﺮﺑاﺮﺑ 5 / 6 و

ﺖﻈﻠﻏرد

mg/ml 30 هدﻮﺑناﺰﯿﻣﻦﯾﺮﺗﻻﺎﺑﺰﮐﻮﻠﮔ )

هرﺎﻤﺷلواﺪﺟ 1

ﺎﺗ

3 ( نﺎـﻣزﻦﯾﺮـﺘﻫﺎـﺗﻮﮐﻂﯾاﺮـﺷﻦـﯾاردﻦﯿﻨﭽﻤﻫو )

ﻗدﻪـﺑ ﯿ ﻪـﻘ ( یاﺮـﺑ

دﻮـﺑزﺎـﯿﻧدرﻮـﻣﺎـﯾازﻪـﻟﻮﻟیارادیﺎـﻫﺮﻤﺨﻣﻦﯿـﻟواهﺪﻫﺎﺸﻣ )

لوﺪـﺟ

هرﺎﻤﺷ 4 .(

یرﺎـﻣآنﻮﻣزآﺎﺑ

One-way ANOVA

ﻦﯿﮕﻧﺎـﯿﻣﻦﯿـﺑتوﺎـﻔﺗ

،ﻒــﻠﺘﺨﻣیﺎــﻫﺎﻣدردﺎــﯾازﻪــﻟﻮﻟیارادیﺎﻬﻟﻮﻠــﺳﺪــﺻرد

pH

یﺎــﻫ

ﺮـﻈﻧزاﯽـﺳرﺮﺑدرﻮﻣﻒﻠﺘﺨﻣیﺎﻬﺘﻈﻠﻏوﻒﻠﺘﺨﻣ رادﯽـﻨﻌﻣیرﺎـﻣآ

دﻮﺑ ) 0001 /

=

( P

.

یرﺎــﻣآنﻮــﻣزآﺎــﺑ

Tukey

یاﺮــﺑ

زاماﺪــﮐﺮﻫودﻪــﺑودﻪﺴــﯾﺎﻘﻣ

ﻣﻦﯿـﺑتوﺎـﻔﺗیﺎﻨﺜﺘـﺳاﻪﺑ،ﺶﯾﺎﻣزآدرﻮﻣﻒﻠﺘﺨﻣیﺎﻫﺮﺘﻣارﺎﭘ ﻦﯿﮕﻧﺎـﯿ

وﺮﻔـﺻﺖـﻈﻠﻏودردﺎـﯾازﻪـﻟﻮﻟیرادیﺎﻬﻟﻮﻠﺳ 10

ﺰﮐﻮـﻠﮔمﺮـﮕﯿﻠﯿﻣ

) 394 / 0

P=

(

،

ودﻪﺑودﻪﺴﯾﺎﻘﻣدراﻮﻣﺮﯾﺎﺳرد توﺎـﻔﺗیارادﺎﻫﺮﺘﻣارﺎﭘ

دﻮﺑرادﯽﻨﻌﻣیرﺎﻣآ )

001 / 0

P=

( .

ــﯾاﺰﻓا ـ ــﺠﺣﺶ ـ ﺣاﻢ ـ ــﻟﺎﻤﺘ ـ داﺪــﻌﺗﯽ یﺎﻬﻟﻮﻠــﺳﯽﯾﺎــﻬﻧ

اﺪــﯾﺪﻧﺎﮐ رد

ﺪﯾدﺮﮔحﻼﺻاﯽﻟﻮﻠﺳنﻮﯿﺴﻧﺎﭙﺳﻮﺳ .

ﺎـﺑﻪﮐﺪﺷﯽﻌﺳﺎﻬﺸﯾﺎﻣزآﻦﯾارد

ﻮﻣﺮﺘﻣارﺎﭘﺮﻫﺮﯿﯿﻐﺗ

دﻮـﺷﻪﺘـﺷاﺪﻬﮕﻧﺖـﺑﺎﺛﺎـﻫﺮﺘﻣارﺎﭘﺮﯾﺎﺳﯽﺳرﺮﺑدر .

یﺮﻤﺨﻣنﻮﯿﺴﻧﺎﭙﺳﻮﺳﻪﯿﻬﺗزاﺲﭘ )

CFU/ml

105 × 1 ( قﻮـﻓﻂﯾاﺮﺷﺎﺑ

ﻞـــﺻاﻮﻓرد 10

ﺎـــﺗﺮﺜﮐاﺪـــﺣویاﻪـــﻘﯿﻗد 2

هﺮـــﻄﻗﮏـــﯾﺖﻋﺎـــﺳ

ﺮﺘﻣﻮﺘﯿــﺳﻮﻤﻫمﻻﮏــﯾیورﺮــﺑارﺖﺴــﺗنﻮﯿﺴــﻧﺎﭙﺳﻮﺳزا )

ﺎــﻣﻮﺗ (

ﺮـﯾزردﺰـﯿﻤﺗﻞـﻣﻻﮏـﯾﺎـﺑنﺪﻧﺎـﺷﻮﭘﺎﺑ،هدادراﺮﻗپﻮﮑﺳوﺮﮑﯿﻣﺮﯾز

ﯿﻣ هرﺎﻤـﺷﯽﺳﺪﻋﺎﺑپﻮﮑﺳوﺮﮑ 40

و 10

ﺪﻧﺪـﺷﯽـﺳرﺮﺑ .

ﻦﯾﺮﺘﻫﺎـﺗﻮﮐ

بﻮــﯿﺗمﺮــﺟﻪﺼــﺨﺸﻣﻒــﯾﺮﻇیﺎــﻫﻪﺘــﺷرﻪــﮐﯽﻧﺎــﻣز )

ﺎــﯾازﻪــﻟﻮﻟ (

ﺖـﺒﺛﺶﯾﺎـﻣزآﺮـﻫردﺪـﺷﯽـﻣهﺪﻫﺎﺸﻣیﺮﻤﺨﻣیﺎﻬﻟﻮﻠﺳفاﺮﻃارد

زاﺲــﭘﺖــﯾﺎﻬﻧردو 2

یﺮــﻤﺨﻣیﺎﻬﻟﻮﻠــﺳﺪﺻردﻦﯿﮕﻧﺎــﯿﻣﺖﻋﺎــﺳ

ﻪﻟﻮﻟﺪﺟاو ردﺎﯾاز

5 وشرﺎﻤـﺷﺶﯾﺎـﻣزآﻂﯾاﺮـﺷﺮﻫیاﺮﺑﺪﯾدناﺪﯿﻣ

ﺪﯾدﺮﮔﻪﺒﺳﺎﺤﻣﺎﻬﻧآرﺎﯿﻌﻣفاﺮﺤﻧاوﻦﯿﮕﻧﺎﯿﻣ .

ﯾﺎﻣزآدرﻮﻣﻂﯾاﺮﺷﺮﻫیاﺮﺑ ـ

ﺶ 5 ﺗ ـ راﺮﮑ ) زا 5 ﻠﮐ ـ ﯽﻨ ﻣ ﺨ ـ ﻠﺘ ـ ﻒ (

اﺪﯾﺪﻧﺎﮐ ﻦﯿﮕﻧﺎﯿﻣوهﺪﺷﺶﯾﺎﻣزآﺲﻨﮑﯿﺒﻟآ ﺪﺻرد

ﻪﻟﻮﻟﺪﺟاویﺎﻬﻟﻮﻠﺳ

ﻒﻠﺘﺨﻣﻂﯾاﺮﺷردارﺎﯾاز یرﺎﻣآﺖﺴﺗﺎﺑ

One-way ANOVA

ﻪﺴﯾﺎﻘﻣ

ﺎﻣد ) داﺮﮕﯿﺘﻧﺎﺳﻪﺟرد (

ﺎﯾازﻪﻟﻮﻟﺪﺟاویﺎﻬﻟﻮﻠﺳﻦﯿﮕﻧﺎﯿﻣ رﺎﯿﻌﻣفاﺮﺤﻧا

27 1

0

32 6

/ 7 14

/ 1

37 45

1

/ 4

42 8

/ 32 8

/ 2

pH

ﺎﯾازﻪﻟﻮﻟﺪﺟاویﺎﻬﻟﻮﻠﺳﻦﯿﮕﻧﺎﯿﻣ رﺎﯿﻌﻣفاﺮﺤﻧا

5 / 5 ﺮﻔﺻ

ﺮﻔﺻ

6 22

4

/ 1

5 / 6 60

6

/ 1

7 8

/ 34 9

/ 1

لوﺪﺟ 1 . یﺎﻬﻟﻮﻠﺳ ﺪﺻرد رﺎﯿﻌﻣ فاﺮﺤﻧا و ﻦﯿﮕﻧﺎﯿﻣ

C. albicans

درﻮﻣ ﻒﻠﺘﺨﻣ یﺎﻬﺗراﺮﺣ رد ﺖﻋﺎﺳ ود زا ﺲﭘ ﺎﯾاز ﻪﻟﻮﻟ ﺪﺟاو ﯽﺳرﺮﺑ

هرﺎﻤﺷ لوﺪﺟ 2

: یﺎﻬﻟﻮﻠﺳ ﺪﺻرد رﺎﯿﻌﻣ فاﺮﺤﻧا و ﻦﯿﮕﻧﺎﯿﻣ

C. albicans

ﺪﺟاو رد ﺖﻋﺎﺳ ود زا ﺲﭘ ﺎﯾاز ﻪﻟﻮﻟ

pH

ﯽﺳرﺮﺑ درﻮﻣ ﻒﻠﺘﺨﻣ

(4)

ﺮﺨﺗﺚﻋﺎﺑ ﯾ ﺐ ﺑلﻮﻠﺳ ﯿ ﻪﻧﺎﮕ دﻮﺷراﻮﺧ )

15 .(

ﺮـﺿﺎﺣﻪﻌﻟﺎﻄﻣﺞﯾﺎﺘﻧ

ﺗﻪـﮐدادنﺎﺸـﻧ وﯽـﻄﯿﺤﻣﻞـﻣاﻮﻋزایداﺪـﻌ

ﺪﻨﻧﺎﻣیاﻪﯾﺬﻐﺗ PH

ﻂﯾاﺮـﺷردﺪـﻧاﻮﺗﯽـﻣﺰﮐﻮﻠﮔﺖﻈﻠﻏوتراﺮﺣ،

ﯽﻫﺎﮕﺸﯾﺎﻣزآ )

ﯽﻨﺗنوﺮﺑ ( ﺑ ﺮ ناﺰـﯿﻣﺖـﻘﯿﻘﺣردﺎـﯾﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗناﺰﯿﻣ

ﺪﺷﺎﺑﺮﺛﻮﻣچرﺎﻗﯽﯾاﺰﯾرﺎﻤﯿﺑوﯽﻤﺟﺎﻬﺗترﺪﻗ .

ﺮﯿﺛﺎـﺗﺮـﺿﺎﺣﻪﻌﻟﺎﻄﻣرد

ﯽﻄﯿﺤﻣﻞﻣﺎﻋ PH

ﯽﻨﻌﯾیاﻪﯾﺬﻐﺗﻞﻣﺎﻋﮏﯾوتراﺮﺣﻪﺟردو ناﺰـﯿﻣ

ناﻮﻨﻋﻪﺑﺰﮐﻮﻠﮔﺖﻈﻠﻏ ﻦﺑﺮﮐﻊﺒﻨﻣ

درﻮﻣ زﺎﯿﻧ چرﺎﻗ رد ﯽﻨﺗنوﺮﺑﻂﯾاﺮﺷ

ﺪﺷﯽﺑﺎﯾزراوﺶﯾﺎﻣزآ .

ﺚﺤﺑ

لﺎﯿﻠﺴﯿﻣمﺮﻓﻪﺑیﺮﻤﺨﻣمﺮﻓزاچرﺎﻗﺖﻟﺎﺣﺮﯿﯿﻐﺗﯽﯾﺎﻧاﻮﺗ )

ﺪـﯿﻟﻮﺗ

ﺎﯾازﻪﻟﻮﻟ ( نﺎـﺑﺰﯿﻣنﺪـﺑردچرﺎـﻗﯽﻤﺟﺎﻬﺗﻢﺴﯿﻧﺎﮑﻣﯽﻋﻮﻧﺖﻘﯿﻘﺣرد

ﯿﺑردﻪﮐدﻮﺷﯽﻣبﻮﺴﺤﻣ ﺲﻨـﮑﯿﺒﻟآاﺪـﯾﺪﻧﺎﮐیﺎـﻫﻪﻧﻮﮔﯽﯾاﺰﯾرﺎﻤ

ﺪﺷﺎﺑﯽﻣﺮﺛﻮﻣ )

1 و 2 .( ﻪـﮐﺖﺳاﻦﯾاﺮﮕﻧﺎﯿﺑﺪﯾﺪﺟتﺎﻌﻟﺎﻄﻣهوﻼﻋﻪﺑ

هﺪﯾﺪﭘﻦﯾا )

ﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗ (

اﺪـﯾﺪﻧﺎﮐچرﺎﻗراﺮﻓیﺎﻬﻤﺴﯿﻧﺎﮑﻣزاﯽﮑﯾ

،دﻮــﺷﯽــﻣبﻮﺴــﺤﻣﯽﻟﻮﻠــﺳﯽــﻨﻤﯾاﻢﺘﺴــﯿﺳزاﺲﻨــﮑﯿﺒﻟآ ز

ــﯾ اﺮ ﻪــﺑ

ﮐ ـ اﮏﻤ ﯾ ﻦ ﮑﻣ ـ ﻧﺎ ﯿـ ﻢﺴ ﻦﯾا چرﺎﻗ ﻣ ﯽ ﺪﻧاﻮﺗ ﺑﯿ ﻪﻧﺎﮕ راﻮﺧ ی ار رﺎﻬﻣ و

ﺰﮐﻮﻠﮔﺖﻈﻠﻏ )

mg/ml ( ﻮﻠﺳﻦﯿﮕﻧﺎﯿﻣ

ﺪﺟاویﺎﻬﻟ

ﺎﯾازﻪﻟﻮﻟ رﺎﯿﻌﻣفاﺮﺤﻧا

ﺮﻔﺻ 21

6

/ 1

10 25

6

/ 1

20 2

/ 57 6

/ 5

30 6

/ 88 8

/ 4

ﺎﻣد

داﺮﮕﯿﺘﻧﺎﺳﻪﺟرد

ﺪﺟاویﺎﻬﻟﻮﻠﺳﻦﯿﮕﻧﺎﯿﻣ ﺎﯾازﻪﻟﻮﻟ رﺎﯿﻌﻣفاﺮﺤﻧا

27 90

8

/ 15

32 70

1

/ 7

37 32

8

/ 14

42 46

4

/ 11

PH

pH

ناﺰﯿﻣ ﺪﺟاویﺎﻬﻟﻮﻠﺳﻦﯿﮕﻧﺎﯿﻣ

ﺎﯾازﻪﻟﻮﻟ رﺎﯿﻌﻣفاﺮﺤﻧا

5 / 5 66

4

/ 11

6 20

1

/ 7

5 / 6 12

5

/ 4

7 30

1

/ 7

ﺰﮐﻮﻠﮔﺖﻈﻠﻏ

(Mg/ml)

ﺖﻈﻠﻏ ﺪﺟاویﺎﻬﻟﻮﻠﺳﻦﯿﮕﻧﺎﯿﻣ

ﺎﯾازﻪﻟﻮﻟ رﺎﯿﻌﻣفاﺮﺤﻧا

ﺮﻔﺻ 36

4

/ 11

10 30

1

/ 7

20 18

5

/ 4

30 12

7

/ 4

هرﺎﻤﺷ لوﺪﺟ 3

: یﺎﻬﻟﻮﻠﺳ ﺪﺻرد رﺎﯿﻌﻣ فاﺮﺤﻧا و ﻦﯿﮕﻧﺎﯿﻣ

C. albicans

د ﺖﻋﺎﺳ ود زا ﺲﭘ ﺎﯾاز ﻪﻟﻮﻟ ﺪﺟاو ﯽﺳرﺮﺑ درﻮﻣ ﺰﮐﻮﻠﮔ ﻒﻠﺘﺨﻣ یﺎﻬﺘﻈﻠﻏ ر

هرﺎﻤﺷ لوﺪﺟ 4

: ﺎﯾاز ﻪﻟﻮﻟ ﺪﯿﻟﻮﺗ عوﺮﺷ نﺎﻣز رﺎﯿﻌﻣ فاﺮﺤﻧا و ﻦﯿﮕﻧﺎﯿﻣ )

ﻪﻘﯿﻗد ( ﺲﻨﮑﯿﺒﻟآ اﺪﯾﺪﻧﺎﮐ ﻂﺳﻮﺗ ﯽﺳرﺮﺑ درﻮﻣ ﻒﻠﺘﺨﻣ ﻂﯾاﺮﺷ رد

36

/

(5)

مود هرود ،ﯽﻫﺎﮕﺸﯾﺎﻣزآ مﻮﻠﻋ ﻪﻠﺠﻣ )

هرﺎﻤﺷ 1 ( نﺎﺘﺴﺑﺎﺗو رﺎﻬﺑ 1387

یزاﻮـﻫﯽـﺑﻂﯾاﺮـﺷردﺎـﯾازﻪـﻟﻮﻟﺪـﯿﻟﻮﺗناﺰﯿﻣهوﻼﻌﺑ )

ﺖـﻈﻠﻏ

CO2

ﺮﺑاﺮﺑ 10 (% ﺖﺳاهدﻮﺑﺮﺘﺸﯿﺑیزاﻮﻫﻂﯾاﺮﺷﺎﺑﻪﺴﯾﺎﻘﻣرد .

Cheng

و

اﺪــﯾﺪﻧﺎﮐﺶﻨــﮐاویورﺮــﺑیاﻪــﻌﻟﺎﻄﻣردنارﺎــﮑﻤﻫ

ﺪـﻧدادنﺎﺸـﻧنﺎـﺑﺰﯿﻣنژوﺮﺘﺳایﻻﺎﺑناﺰﯿﻣﺎﺑتروﺎﺠﻣردﺲﻨﮑﯿﺒﻟآ

ـﻋﺎﺑﺪـﻧاﻮﺗﯽﻣنژوﺮﺘﺳایﻻﺎﺑﺮﺘﯿﺗﻪﮐ ﺪـﯿﻟﻮﺗﺖﻋﺮـﺳردﺪﯾﺪﺸـﺗﺚ

دﻮـﺷچرﺎـﻗﻦـﯾاردﺎـﯾازﻪﻟﻮﻟلﻮﻃﺶﯾاﺰﻓاوﺎﯾازﻪﻟﻮﻟ .

نﺎﺸـﻧﺎـﻬﻧآ

ﺪﻧاﻮﺗﯽﻣنژوﺮﺘﺳایﻻﺎﺑﺮﺘﯿﺗﻪﮐﺪﻧداد ﻪﺑچرﺎﻗﻦﯾاﮏﯾﺮﺤﺗﺚﻋﺎﺑ

دﻮﺷﺎﻬﻤﻧﺎﺧردﯽﯾاﺪﯾﺪﻧﺎﮐﺖﯿﻨﯾژاودﺎﭽﯾا )

21 .(

یﺮﯿﮔﻪﺠﯿﺘﻧ

ﯽـﻣﺮـﻈﻧﻪﺑﺮـﺿﺎﺣﻪـﻌﻟﺎﻄﻣزاهﺪـﻣآﺖـﺳدﻪﺑﺞﯾﺎﺘﻧﻪﺑﻪﺟﻮﺗﺎﺑ

ﮐﺪﺳر ﺶﻫﺎـﮐوﺰﮐﻮـﻠﮔیﻻﺎـﺑﺖـﻈﻠﻏﻢـﻫنﺎﺑﺰﯿﻣنﺪﺑردﻪ

pH

ﺚﻋﺎﺑ ﮏﯾﺮﺤﺗ ردصﻮﺼـﺧﻪـﺑ،نﺪـﺑردﺎـﯾازﻪـﻟﻮﻟﺪﯿﻟﻮﺗﻪﺑچرﺎﻗ

ﺎـﺑﻪﺑﺎﺸـﻣچرﺎـﻗﺲﻧﻻوﺮـﯾوﺪﯾﺪﺸـﺗﺚـﻋﺎﺑﻪﺠﯿﺘﻧردوﯽﺘﺑﺎﯾدداﺮﻓا

دﻮــﺷﯽــﻣﯽــﻨﺗنوﺮــﺑﻂﯾاﺮــﺷ .

ــﻨﮐﻞــﯿﻟدﻦﯿــﻤﻫﻪــﺑ ـ

نﻮــﺧﺪــﻨﻗلﺮﺘ

ﯿﺑرد ـ ﺘﺑﺎﯾدنارﺎﻤ ـ

ﯾﺪﻧﺎﮐﻪﺑﻼﺘﺑازایﺮﯿﮔﻮﻠﺟردﯽ رﻮـﻃﻪـﺑﺲﯾزﺎﯾﺪ

ﺪﻨﮐﯽﻣﮏﻤﮐﺮﺛﺆﻣ .

ﯽﻧادرﺪﻗوﺮﮑﺸﺗ

ﺎﺑﻖﯿﻘﺤﺗﻦﯾامﺎﺠﻧاردﻪﮐﯽﻟﺎﺒﺟﯽﻠﻋوﺮﻔﻨﯾرزﻦﯿﺴﺣنﺎﯾﺎﻗآزا

ﺪﯾآﯽﻣﻞﻤﻌﺑﺮﮑﺸﺗوﺮﯾﺪﻘﺗﺪﻧاﻪﺘﺷادیرﺎﮑﻤﻫهﺪﻨﺑ .

تراﺮـﺣ 37 ـﺟرد ـ ﻧﺎﺳﻪ ـﺘ ـــ ،داﺮـﮔﯽ

pH

ﺮـﺑاﺮﺑ 5 / 6 ﻠﻏو ـ ـﻈ ـ ﺖ

mg/ml

30 ﻪــﻟﻮﻟﺪﯿﻟﻮﺗﮏــﯾﺮﺤﺗﺚــﻋﺎﺑﺰﮐﻮــﻠﮔ اﺪــﯾﺪﻧﺎﮐﻂــﺳﻮﺗﺎــﯾاز

ﺮﯾﺎـﺳﺎﺑﻪﺴﯾﺎﻘﻣردﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗناﺰﯿﻣﺶﯾاﺰﻓاﻦﯾاﻪﮐﺪﺷﺲﻨﮑﯿﺒﻟآ

دﻮﺑرادﯽﻨﻌﻣیرﺎﻣآﺮﻈﻧزاﻂﯾاﺮﺷ )

0001

=/ ( P

ردﺎـﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗﮏﯾﺮﺤﺗ

pH

ﺮـﺑاﺮﺑ 5 / 6 تراﺮـﺣو 37

ﻪـﺟرد

ﺮﮕﯾدتﺎﻌﻟﺎﻄﻣﺞﯾﺎﺘﻧﺎﺑﻪﺑﺎﺸﻣداﺮﮔﯽﺘﻧﺎﺳ )

16 و 17 ( ﺖﻈﻠﻏﺮﯿﺛﺎﺗ،هدﻮﺑ

اردﻪﮐﺰﮐﻮﻠﮔ ﻪﻌﻟﺎﻄﻣﻪﺑﺎﺸﻣ،ﺖﺳاهﺪﺷﯽﺳرﺮﺑﻪﻌﻟﺎﻄﻣﻦﯾ

Casanova

زاﺎﻬﻧآﻪﻌﻟﺎﻄﻣردﻪﮐﺖﺳانارﺎﮑﻤﻫو

3-acetyl-D-glucoseamine

و

Hemin

ﻪـﺘﻓررﺎﮐﻪـﺑﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗﮏﯾﺮﺤﺗیاﺮﺑﻦﺑﺮﮐﻊﺒﻨﻣناﻮﻨﻋﻪﺑ

دﻮــﺑ ) 18 .( ﻦــﯾاردﺎــﯾازﻪــﻟﻮﻟﺪــﯿﻟﻮﺗﮏــﯾﺮﺤﺗردﺰﮐﻮﻠﮔیﻻﺎــﺑﺖــﻈﻠﻏ

ﺖﯿﻤﻫاهﺪﻨﻫدنﺎﺸﻧﺖﺳاﻦﮑﻤﻣﻪﻌﻟﺎﻄﻣ چرﺎـﻗﻦـﯾایﻻﺎـﺑﯽﯾاﺰﯾرﺎـﻤﯿﺑ

ﺪﺷﺎﺑﯽﺘﺑﺎﯾدنارﺎﻤﯿﺑرد .

ﺖﻈﻠﻏلدﺎﻌﻣﺶﯾﺎﻣزآﻪﻟﻮﻟردﺰﮐﻮﻠﮔﺮﻔﺻﺖﻈﻠﻏﻪﻌﻟﺎﻄﻣﻦﯾارد

ﯽﻌﯿﺒﻃﺰﮐﻮﻠﮔناﺰﯿﻣﺎﺑدﺮﻓنﻮﺧ )

هدﺎﻔﺘـﺳاﺖﺴـﺗیاﺮـﺑلﺎـﻣﺮﻧدﺮﻓمﺮﺳ

هﺪﺷ ( , ﺖﻈﻠﻏ 10 , 20 و 30 ﺶﯾﺎﻣزآﻪﻟﻮﻟردﺮﺘﯿﻟﯽﻠﯿﻣﺮﻫردمﺮﮔﯽﻠﯿﻣ

ﺮﺳﺖﻈﻠﻏناﺰﯿﻣلدﺎﻌﻣﺐﯿﺗﺮﺗﻪﺑ ناﺰﯿﻣﺎﺑیدﺮﻓﺰﮐﻮﻠﮔﯽﻣ

200 , 300 و

400 ﻣ ﺪﺷﺎﺑﯽﻣمﺮﺳﺮﺘﯿﻟﯽﺳدﺮﻫردمﺮﮕﯿﻠﯿ .

یﻻﺎﺑیﺎﻬﺘﻈﻏردﺎﯾازﻪﻟﻮﻟﺪﯿﻟﻮﺗناﺰﯿﻣوﺪﯿﻟﻮﺗردﺖﻋﺮﺳﺶﯾاﺰﻓا

ﻦـﯾانﺪـﺷاﺰﯾرﺎـﻤﯿﺑهﺪـﻨﻫدنﺎﺸـﻧﺖﺳاﻦﮑﻤﻣﺮﺿﺎﺣﻪﻌﻟﺎﻄﻣردﺰﮐﻮﻠﮔ

ﺪـﺷﺎﺑﯽﺘﺑﺎـﯾدنارﺎـﻤﯿﺑردنآﯽﻤﺟﺎﻬﺗترﺪﻗﺶﯾاﺰﻓاوچرﺎﻗ .

یرﺎـﻤﯿﺑ

ﺘﺑﺎﯾد

نﺪـﺷاﺰﯾرﺎـﻤﯿﺑیاﺮـﺑزﺎـﺳﻪـﻨﯿﻣزوهﺪﻨﻨﮐﺪﻌﺘﺴﻣﻞﻣاﻮﻋﻪﻠﻤﺟزاﯽ

ﯽﻨﯿﻟﺎـﺑﻢـﯾﻼﻋزوﺮـﺑﺚﻋﺎﺑﺖﺳاﻦﮑﻤﻣوهدﻮﺑاﺪﯾﺪﻧﺎﮐﻪﻠﻤﺟزاﺎﻬﭼرﺎﻗ

یﺪــﻠﺟ،یﺪــﻠﺟ

دﻮــﺷﺎــﻬﯿﺘﺑﺎﯾدردﺲﯾزﺎﯾﺪــﯾﺪﻧﺎﮐهﺮﺸــﺘﻨﻣوﯽﻃﺎــﺨﻣ

) 7،15 .(

ﺪـﯿﻟﻮﺗناﺰـﯿﻣهﺪـﻨﯾاﺰﻓاوهﺪـﻨﻨﮐﮏﯾﺮﺤﺗﺮﯿﺛﺎﺗﯽﻬﺑﺎﺸﻣتﺎﻌﻟﺎﻄﻣرد

ﯾﺪﻧﺎﮐﺎﺑ ﺎﯾازﻪﻟﻮﻟ ﻦﯿـﻤﻫﺪﻨﻧﺎﻣﯽﻔﻠﺘﺨﻣﻞﻣاﻮﻋﺮﺑﺲﻨﮑﯿﺒﻟآاﺪ

)

Hemin

(

) 18 (

ﯽﭼرﺎـﻗﺪـﺿیﺎﻫوراد، )

19 ( ﺎﻫﺪﯿـﺳاﻮﻨﯿﻣآﯽﻀـﻌﺑ، )

8 ( ﮏـﯾو

ﺖﮐﻼﭘزاهﺪﺷﻪﺘﻓﺮﮔﻞﻣﺎﻋ )

20 ( وهﺪـﺷﺶﯾﺎﻣزآﯽﻨﺗنوﺮﺑﻂﯾاﺮﺷرد

ﺖﺳاهﺪﺷهدادنﺎﺸﻧ .

رد ﻦﯾا ﺎﻬﺸﯾﺎﻣزآیاﺮﺑﻪﻌﻟﺎﻄﻣ ی

ﻪﻟﻮﻟﺪﯿﻟﻮﺗ ﺎﯾاز رد

ﻂﯾاﺮﺷ ﯽﻫﺎﮕﺸﯾﺎﻣزآ ﺴﻧامﺮﺳزا

ﺪﺷهدﺎﻔﺘﺳانﺎ .

Isibok نارﺎﮑﻤﻫو )

14 ( هدﺎﻔﺘـﺳاﻪـﮐﺪﻧدادنﺎﺸـﻧیاﻪـﻌﻟﺎﻄﻣرد

ﺪﻨﻔـﺳﻮﮔووﺎـﮔمﺮـﺳﺎﺑﻪﺴـﯾﺎﻘﻣردﺎـﯾازﻪـﻟﻮﻟﺖﺴـﺗیاﺮﺑنﺎﺴﻧامﺮﺳزا

ﺖﺳاﺮﺗﺪﯿﻔﻣ .

(6)

References

1) Warnock DW. Trends in the epidemiology of invasive fungal infections. Nippon Ishinkin Gakkai Zasshi. 2007;48(1):1-12. 2) Galle F, Catania MR, Liguori G. Nosocomial candida infections: epidemiology of candidaemia.J Prev Med Hyg. 2006;47(3):119-26

3) De Marie S.New developments in the diagnosis and management of invasive fungal infections 2000;85(1):88-93. 4) Ray D, Goswami R, Dadhwal V, Goswami D, Banerjee U, Kochupillai N. Prolonged (3-month) mycological cure rate after boric acid suppositories in diabetic women with vulvovaginal candidiasis . 2007;55(4):374-7. Epub 2007;10. 5) Sheng WH, Wang JT, Lin MS, Chang SC. Risk factors affecting in-hospital mortality in patients with nosocomial infections.J Formos Med Assoc. 2007;106(2):110-8.

6) Verduyn Lunel FM, Meis JF, Voss A.Nosocomial fungal infections: candidemia. Diagn Microbiol Infect Dis. 1999;34(3):213-20

7) Calderone, RA. Candida and Candidiasis. ASM Press, Washington D.C. 2002.

8) Munin E, Giroldo LM, Alves LP, Costa MS. Study of germ tube formation by Candida albicans after photodynamic antimicrobial chemotherapy (PACT). 2007;27;88(1):16-20. Epub 2007 . 8.

9). Marot-Leblond A, Grimaud L, Nail S, Bouterige S, Apaire-Marchais V, Sullivan DJ, etal. New monoclonal antibody specific for Candida albicans germ tube.J Clin Microbiol. 2000 ;38(1):61-7.

10) Merson-Davies L, Hopwood V, Robert R, Marot-Leblond A, Senet JM, Odds FC. Reaction of Candida albicans cells of different morphology index with monoclonal antibodies specific for the hyphal form.J Med Microbiol. 1991;35(6):321-4

11) Hudson DA, Sciascia QL, Sanders RJ, Norris GE, Edwards PJ, Sullivan PA, etal. Identification of the dialysable serum inducer of germ-tube formation in Candida albicans Microbiology. 2004;150(Pt 9):3041-9

12) Ollert MW, and Calderone RA. A monoclonal antibody that defines a surface antigen on Candida albicans hyphae cross-reacts with yeast cell protoplasts. 1990;58(3):625-31.

13) Torosantucci A, Gomez MJ, Bromuro C, Casalinuovo I, Cassone A. Biochemical and antigenic characterization of mannoprotein constituents released from yeast and mycelial forms of Candida albicans. J Med Vet Mycol. 1991;29(6):361-72.

14) Isibor JO, Eghubare AE, Omoregie R. Germ Tube Formation in Candida albicans: Evaluation of Human and Animal Sera and Incubation Atmosphere. Shiraz E-Medical Journal 2005; 6(1&2). (http://semj.sums.ac.ir/vol6/jan2005/germtube.htm).

15) Ajello L and Haaay RJ. Candida species and Blastoshizomyces, Microbiology and Microbial Infections, Nineth edition, Volum 4 (Medical Mycology), Arnold 1998, 423-460.

16) Buffo J, Herman MA, Soll DR. A characterization of pH-regulated dimorphism in Candida albicans Mycopathologia. 1984;15;85(1-2):21-30.

17) Pazos C, Moragues MD, Quindós G, Pontón J, del Palacio A. Diagnostic potential of (1,3)-beta-D-glucan and anti-Candida albicans germ tube antibodies for the diagnosis and therapeutic monitoring of invasive candidiasis in neutropenic adult patients. Rev Iberoam Micol. 2006;23(4):209-15.

18) Casanova M, Cervera AM, Gozalbo D, Martínez JP. Hemin induces germ tube formation in Candida albicans.Infect Immun. 1997;65(10):4360-4.

19) Vale-Silva LA, Buchta V, Valentová E. Effect of subinhibitory concentration of some established and experimental antifungal compounds on the germ tube formation in Candida albicans. Folia Microbiol (Praha). 2007;52(1):39-43. 20) Kennedy MJ, Calderone RA, Cutler JE, Kanabe T, Riesselman MH, Robert R, etal . Molecular basis of Candida albicans adhesion.J Med Vet Mycol. 1992;30 Suppl 1:95-122. 21) Cheng G, Yeater KM, Hoyer LL.Cellular and olecular biology of Candida albicans estrogen response Eukaryot Cell. 2006;5(1):180-91.

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