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A sodium channel knockin mutant (NaV1 4 R669H) mouse model of hypokalemic periodic paralysis

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Figure

Figure 1Construction and genetic analysis of the
Figure 2In vitro contraction testing demonstrates a HypoPP phenotype. (
Figure 3Recovery from weakness was ouabain sensitive. In vitro contraction responses from R669Hm/m muscle exposed to 3 mM K+ were used to assess whether spontaneous recovery of force during hypokalemia was ouabain sensitive
Figure 4In vivo reduction of muscle excitability and force from glucose plus insulin challenge
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